Results 251 to 260 of about 7,352,857 (294)

Versatile Microgel Platform for Intervertebral Disc Degeneration Therapy: Targeting Pericyte‐Mediated Fibrosis and Protecting Nucleus Pulposus Cells

Advanced Science, EarlyView.
The engineered MMS@TRP microgel enables targeted, acid‐responsive delivery of a miR‐21 inhibitor to pericytes. It effectively suppresses disc fibrosis by inhibiting TGF‐β signaling while protecting nucleus pulposus cells via sustained, antioxidant tannic acid release.
Fei Ma, Zhen Zhao, Chuan Guo, Yuheng Liu, Yu Wang, Dengbo Yao, Weiqiang Lan, Dejun Zhong, Chen Fan, Yao He, Mei Zhang, Qingquan Kong, Yunfeng Lin   +12 more
wiley   +1 more source

Coordinated dynamics of circulating neutrophils, regulatory T lymphocytes, myeloid derived suppressor cells and distinct granulocytic subsets reveal a complex immune network in metastatic colorectal cancer. [PDF]

Front Oncol
Zafeiriou Z, Koutoulaki A, Aggouraki D, Koinis F, Vardakis N, Voutsina A, Papadogiannaki K, Kotta K, Vetsika EK, Mavroudis D, Georgoulias V, Kotsakis A.   +11 more
europepmc   +1 more source

Sphingosine kinase-2 inhibition promotes immunogenic differentiation of myeloid-derived suppressor cells through an Acetyl-CoA carboxylase-phosphatidylcholine axis. [PDF]

Nat Commun
Chakraborty P, Chatterjee S, Kassir MF, Wofford W, Choi S, Oleinik N, Saatci O, Darawshi O, Das S, Oberhoeltzer N, Gautam A, Mills S, DeMass R, Hedley Z, Liu Y, Parikh RY, Paul S, Seal S, Smith CD, Lilly MB, Gangaraju VK, Peterson Y, Mehrotra M, Hill E, Sahin O, Leitinger N, Rodriguez PC, Ogretmen B, Mehrotra S.   +28 more
europepmc   +1 more source

Polymorphonuclear Myeloid-Derived Suppressor Cells Promote Rheumatoid Arthritis by Inducing Age-Associated B Cells Proliferation and Differentiation via the BAFF-Mediated SYK-ERK1/2 Pathway. [PDF]

FASEB J
Hong H, Wang Y, Yan S, Yin F, Wang Y, Zhang J, Tang X, Li M, Zhang H, Sun L.   +9 more
europepmc   +1 more source

m⁶A RNA modification and myeloid-derived suppressor cells: mechanistic insights and clinical prospects. [PDF]

Front Immunol
Li C, Jiang X, Yuan Y, Chen X, Pu S, Lian K, Li L, Wang Q.   +7 more
europepmc   +1 more source

Defining the marker and developmental trajectory of myeloid-derived suppressor cells in aging by single-cell transcriptomics. [PDF]

NPJ Aging
Su Y, Wu R, Ai H, Zhong Z, Zou L, Wang Z, Tu K, Tang L, Gao J, Huang Y, Liao C, Zeng G, Zhang H, Jin J, Zhu S.   +14 more
europepmc   +1 more source

Alpha-ketoglutarate Potentiates IL-1β Production and Suppressive Mechanisms of Myeloid-Derived Suppressor Cells by Altering Redox Metabolism and Inducing Autophagy. [PDF]

Int J Biol Sci
Milanović M, Pavlović L, Bekić M, Đokić J, Stojadinović M, Radojević D, Čolić M, Tomić S.   +7 more
europepmc   +1 more source

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Myeloid-Derived Suppressor Cells and Radiotherapy

Cancer Immunology Research, 2022
Abstract Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of pathologically activated, mostly immature, myeloid cells that exert robust immunosuppressive functions. MDSCs expand during oncogenesis and have been linked to accelerated disease progression and resistance to treatment in both preclinical tumor models ...
Carlos Jiménez-Cortegana, Claudia Galassi, Vanessa Klapp, Dmitry I. Gabrilovich, Lorenzo Galluzzi   +4 more
openaire   +2 more sources