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Myeloid Derived Suppressor Cells
2016Myeloid derived suppressor cells (MDSCs) comprise a phenotypically heterogeneous population of cells, which can be found in tumor bearing mice and in patients with cancer. MDSCs play a central role in the induction of peripheral tolerance. Together with regulatory T cells (Tregs) they promote an immunosuppressive environment in tumor-bearing hosts.
Taku Fujimura, Alexander H. Enk
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Myeloidâderived suppressor cells in parasitic infections
European Journal of Immunology, 2010AbstractMyeloidâderived suppressor cells (MDSC) are a heterogeneous population of immature myeloid cells that share a common property of suppressing immune responses. Several helminth and protozoan parasite species have developed efficient strategies to increase the rate of medullary or extramedullary myelopoiesis and to induce the expansion and ...
Van Ginderachter, Jo A +3 more
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Myeloid-Derived Suppressor Cells in Cancer
2007Accumulation of suppressive leukocytes is the hallmark of several pathological conditions, including tumors. Among these leukocytes, myeloid-derived suppressor cells (MDSCs) are thought to play a major role in regulating antitumor immunity. MDSCs encompass a heterogeneous population characterized by its myeloid origin and ability to suppress T-cell ...
Serafini P., Bronte, Vincenzo
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Myeloid-Derived Suppressor Cells in Multiple Myeloma.
Blood, 2009Abstract Abstract 2794 Poster Board II-770 Myeloid-derived suppressor cells (MDSCs) are a heterogeneous mix of myeloid cells in different maturation stages generated in the bone marrow. The role of MDSCs in cancer is to suppress T-cell responses, thereby likely regulating tumor progression.
Van Valckenborgh, Els +4 more
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Therapeutic targeting of myeloid-derived suppressor cells
Current Opinion in Pharmacology, 2009Myeloid-derived suppressor cells (MDSCs) represent a subset of myeloid cells that expand under pathological conditions, such as cancer development, acute and chronic infections, trauma, bone marrow transplantations, and some autoimmune diseases. MDSCs mediate a negative regulation of the immune response by affecting different T lymphocyte subsets ...
Ugel, Stefano +7 more
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MDSC: Myeloid-Derived Suppressor Cells
2016Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature myeloid cells whose numbers are increased in states of cancer, inflammation, or infection. MDSC are reported to be induced by tumor-produced growth factors in cancer-bearing hosts. Mechanisms of immune suppression by MDSC include production of arginase-1, reactive oxygen
Masahiko Shibata +2 more
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Targeting Myeloid-Derived Suppressor Cells in Cancer
2017Myeloid derived suppressor cells (MDSC) represent only a minor fraction of circulating blood cells but play an important role in tumor formation and progression. They are a heterogeneous group of cells that influence the tumor microenvironment by depletion of amino acids, oxidative stress, decreased trafficking of antitumor effector cells, and ...
Waseem, Anani, Michael R, Shurin
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Myeloid-derived suppressor cells: Identification and function
Myeloid-derived suppressor cells (MDSCs) are cells that play a regulatory role in immune responses and inflammation. They can have both positive and negative effects on various diseases, including cancer, infections, sepsis, and trauma. MDSCs inhibit immune cells by releasing immunosuppressive factors and can be categorized as monocytic (M) or ...Paola, Vacca +3 more
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Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity
Nature Reviews Immunology, 2021Filippo Veglia +2 more
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The intratumor mycobiome promotes lung cancer progression via myeloid-derived suppressor cells
Cancer Cell, 2023Ning-Ning Liu, Christopher Heeschen
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