Results 261 to 270 of about 7,352,857 (294)

Myeloid derived suppressor cells in transplantation

Current Opinion in Immunology, 2011
Myeloid derived suppressor cells (MDSC) are a heterogeneous population of hematopoietic derived cell precursors that can suppress immune responses in a variety of inflammatory settings. Here we review recent studies detailing expansion of phenotypically and functionally disparate MDSC.
Jason R, Lees, Agnes M, Azimzadeh, Jonathan S, Bromberg   +2 more
openaire   +2 more sources

Myeloid-derived suppressor cells in glioma

Expert Review of Neurotherapeutics, 2013
Glioblastoma is the most prevalent form of gliomas with high aggressive nature and high recurrence. Despite aggressive therapy, including surgery, chemotherapy and radiotherapy, median patient survival is only about 15 months. Hence, developing novel and efficient therapies seem urgent.
Masoud, Mirghorbani, Stefaan, Van Gool, Nima, Rezaei   +2 more
openaire   +2 more sources

Myeloid-Derived Suppressor Cells

2007
The development of tumor-specific T cell tolerance is largely responsible for tumor escape. Accumulation of myeloid-derived suppressor cells (MDSCs) in animal tumor models as well as in cancer patients is involved in tumor-associated T cell tolerance.
Srinivas, Nagaraj, Dmitry I, Gabrilovich
openaire   +2 more sources

Myeloid-derived suppressor cells in transplantation

Current Opinion in Organ Transplantation, 2010
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature cells that are considered as potential therapeutic targets. Indeed, MDSCs have been shown to suppress immune responses to several types of tumor cells and blocking their suppressive activity may adequately enhance immune response against tumor antigens. On the contrary,
Dilek, Nahzli, Van Rompaey, Nicolas, Le Moine, Alain, Vanhove, Bernard   +3 more
openaire   +3 more sources

Myeloid Derived Suppressor Cells

2016
Myeloid derived suppressor cells (MDSCs) comprise a phenotypically heterogeneous population of cells, which can be found in tumor bearing mice and in patients with cancer. MDSCs play a central role in the induction of peripheral tolerance. Together with regulatory T cells (Tregs) they promote an immunosuppressive environment in tumor-bearing hosts.
Taku Fujimura, Alexander H. Enk
openaire   +1 more source

The roles of myeloid-derived suppressor cells in transplantation

Expert Review of Clinical Immunology, 2014
CD11b(+)Gr1(+) myeloid-derived suppressor cells (MDSCs) are an important regulatory innate cell population and have significant inhibitory effect on T cell-mediated responses. In addition to their negative role in cancer development, MDSCs also exert strong regulatory effects on transplantation and autoimmunity.
Tingting, Wu, Yang, Zhao, Yong, Zhao
exaly   +3 more sources

Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

2020
Myeloid-derived suppressor cells (MDSCs) represent a heterogenous population of immature myeloid cells capable of modulating immune responses. In the context of cancer, MDSCs are abnormally produced and recruited to the tumor microenvironment (TME) to aid in the establishment of an immunosuppressive TME that facilitates tumor escape.
Matthew, Dysthe, Robin, Parihar
openaire   +2 more sources

Targeting Myeloid-Derived Suppressor Cells in Cancer

2017
Myeloid derived suppressor cells (MDSC) represent only a minor fraction of circulating blood cells but play an important role in tumor formation and progression. They are a heterogeneous group of cells that influence the tumor microenvironment by depletion of amino acids, oxidative stress, decreased trafficking of antitumor effector cells, and ...
Waseem, Anani, Michael R, Shurin
openaire   +2 more sources

Defining myeloid-derived suppressor cells

Nature Reviews Immunology
Leila Akkari, Ido Amit, Vincenzo Bronte, Zvi G. Fridlender, Dmitry I. Gabrilovich, Florent Ginhoux, Catherine C. Hedrick, Suzanne Ostrand-Rosenberg   +7 more
openaire   +2 more sources

Regulation of myeloid-derived suppressor cells by glutamate

Folia Pharmacologica Japonica
Myeloid-derived suppressor cells (MDSCs) suppress anti-tumor immunity in tumor bearers, which leads to tumor progression. Immune checkpoint blockers (ICBs) demonstrated significant efficiency against various cancers; however, their success rate is limited to approximately 20-30% in patients with cancer. To address this limitation, predictive biomarkers
openaire   +2 more sources