Results 21 to 30 of about 43,612 (265)

HIF-1α/MMP-9 Axis Is Required in the Early Phases of Skeletal Myoblast Differentiation under Normoxia Condition In Vitro

Cells, 2023
Hypoxia-inducible factor (HIF)-1α represents an oxygen-sensitive subunit of HIF transcriptional factor, which is usually degraded in normoxia and stabilized in hypoxia to regulate several target gene expressions.
Flaminia Chellini, Alessia Tani, Martina Parigi, Francesco Palmieri, Rachele Garella, Sandra Zecchi-Orlandini, Roberta Squecco, Chiara Sassoli   +7 more
doaj   +1 more source

Crosstalk Between Innate and T Cell Adaptive Immunity With(in) the Muscle

Frontiers in Physiology, 2020
Growing evidence demonstrates a continuous interaction between the immune system and the skeletal muscle in inflammatory diseases of different pathogenetic origins, in dystrophic conditions such as Duchenne Muscular Dystrophy as well as during normal ...
Adriana C. Bonomo, Adriana C. Bonomo, Adriana C. Bonomo, Fernanda Pinto-Mariz, Ingo Riederer, Ingo Riederer, Ingo Riederer, Ingo Riederer, Claudia F. Benjamim, Claudia F. Benjamim, Gillian Butler-Browne, Vincent Mouly, Wilson Savino, Wilson Savino, Wilson Savino   +14 more
doaj   +1 more source

Optimized lentiviral vector to restore full-length dystrophin via a cell-mediated approach in a mouse model of Duchenne muscular dystrophy

Molecular Therapy: Methods & Clinical Development, 2022
Duchenne muscular dystrophy (DMD) is a muscle wasting disorder caused by mutations in the DMD gene. Restoration of full-length dystrophin protein in skeletal muscle would have therapeutic benefit, but lentivirally mediated delivery of such a large gene ...
Jinhong Meng, Marc Moore, John Counsell, Francesco Muntoni, Linda Popplewell, Jennifer Morgan   +5 more
doaj   +1 more source

Follistatin could promote the proliferation of duck primary myoblasts by activating PI3K/Akt/mTOR signalling

Bioscience Reports, 2014
FST (follistatin) is essential for skeletal muscle development, but the intracellular signalling networks that regulate FST-induced effects are not well defined.
Xinxin Li, Hehe Liu, Haohan Wang, Lingli Sun, Fang Ding, Wenqiang Sun, Chunchun Han, Jiwen Wang   +7 more
doaj   +1 more source

PERK Signaling Controls Myoblast Differentiation by Regulating MicroRNA Networks

Frontiers in Cell and Developmental Biology, 2021
The unfolded protein response (UPR) plays important roles in various cells that have a high demand for protein folding, which are involved in the process of cell differentiation and development.
Ye-Ya Tan, Yin Zhang, Yin Zhang, Bin Li, Yang-Wen Ou, Shu-Juan Xie, Pei-Pei Chen, Shi-Qiang Mei, Qiao-Juan Huang, Ling-Ling Zheng, Liang-Hu Qu   +10 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Expression profiling by high-throughput sequencing reveals GADD45, SMAD7, EGR-1 and HOXA3 activation in Myostatin (MSTN) and GDF11 treated myoblasts [PDF]

Genetics and Molecular Biology
Growth differentiation factor 11 (GDF11) and myostatin (MSTN/GDF8) are closely related members of the transforming growth factor β (TGFβ) superfamily, sharing structural homology.
Platon Braun, Malik Alawi, Ceren Saygi, Klaus Pantel, Amy J. Wagers   +4 more
doaj   +1 more source

Effect of Neudesin Neurotrophic Factor on Differentiation of Bovine Preadipocytes and Myoblasts in a Co-Culture System

Animals, 2020
In this study, we successfully established a co-culture system of bovine preadipocytes and myoblasts to explore the effect of exogenous addition of Neudesin neurotrophic factor (NENF) recombinant protein on the differentiation of adipocytes and myoblasts
Anqi Li, Xiaotong Su, Yaning Wang, Gong Cheng, Linsen Zan, Hongbao Wang   +5 more
doaj   +1 more source

Light‐Assisted 3D Printing Techniques and Photocrosslinking Strategies: Recent Advances in Musculoskeletal Tissue Engineering

Advanced Engineering Materials, EarlyView.
In this review, the current state of light‐assisted 3D printing as it pertains to engineering musculoskeletal tissues including bone, cartilage, skeletal muscle, tendon, and ligaments is summarized. Common printing techniques, photoreactive materials, and study design choices are compiled and reviewed.
Meagan Morgan, Bin Zhang, Roger Narayan
wiley   +1 more source

A triple co-culture method to investigate the effect of macrophages and fibroblasts on myoblast proliferation and migration

BioTechniques, 2018
The communication between nonmyogenic cells, such as macrophages and fibroblasts, and myoblasts is crucial for successful skeletal muscle repair. In vitro co-culture methods can be used to increase our understanding of these cellular interactions ...
Colin Venter, Carola Niesler
doaj   +1 more source