Results 21 to 30 of about 54,075 (312)
LKB1 Destabilizes Microtubules in Myoblasts and Contributes to Myoblast Differentiation
PLoS ONE, 2012 Skeletal muscle myoblast differentiation and fusion into multinucleate myotubes is associated with dramatic cytoskeletal changes. We find that microtubules in differentiated myotubes are highly stabilized, but premature microtubule stabilization blocks differentiation.
Isma Mian +5 more
openaire +4 more sources
Bioengineering, 2022 In skeletal muscles, muscle fibers are highly organized and bundled within the basement membrane. Several microfabricated substrate models have failed to mimic the macrostructure of native muscle, including various extracellular matrix (ECM) proteins ...
Satoshi Nakada +4 more
doaj +1 more source
Myogenetic oligodeoxynucleotide complexed with berberine promotes differentiation of chicken myoblasts [PDF]
, 2021 Myoblasts are myogenic precursors that develop into myotubes during muscle formation. Improving efficiency of myoblast differentiation is important for advancing meat production by domestic animals.
Tamao Ono +13 more
core +1 more source
Changes in Expression of Proteolytic-Related Genes in Chick Myoblasts during Myogenesis
The Journal of Poultry Science, 2011 Changes in expression of proteolytic-related genes in chick myoblasts during myogenesis were investigated. Expression of MyoD and myogenin, as an index of differentiation, was regulated in chick myoblasts during myogenesis.
Kazuki Nakashima +2 more
doaj +1 more source
Cells, 2023 Hypoxia-inducible factor (HIF)-1α represents an oxygen-sensitive subunit of HIF transcriptional factor, which is usually degraded in normoxia and stabilized in hypoxia to regulate several target gene expressions.
Flaminia Chellini +7 more
doaj +1 more source
DLL1 loss-of-function study in human myoblasts.
, 2021 (A) Schematic of CRISPR/Cas9 approach to generate gene-knockout clones from human myoblasts. (B) Schematic of human DLL1 gene structure and the sequences of gRNAs in exon 4. (C) DNA electrophoresis results of DLL1 genotyping PCR.
Haifeng Zhang (137541) +2 more
core +1 more source
Crosstalk Between Innate and T Cell Adaptive Immunity With(in) the Muscle
Frontiers in Physiology, 2020 Growing evidence demonstrates a continuous interaction between the immune system and the skeletal muscle in inflammatory diseases of different pathogenetic origins, in dystrophic conditions such as Duchenne Muscular Dystrophy as well as during normal ...
Adriana C. Bonomo +14 more
doaj +1 more source
Nuclei of Non-Muscle Cells Bind Centrosome Proteins upon Fusion with Differentiating Myoblasts
, 2009 Background: In differentiating myoblasts, the microtubule network is reorganized from a centrosome-bound, radial array into parallel fibres, aligned along the long axis of the cell.
Espigat-Georger Aude +11 more
core +1 more source
Molecular Therapy: Methods & Clinical Development, 2022 Duchenne muscular dystrophy (DMD) is a muscle wasting disorder caused by mutations in the DMD gene. Restoration of full-length dystrophin protein in skeletal muscle would have therapeutic benefit, but lentivirally mediated delivery of such a large gene ...
Jinhong Meng +5 more
doaj +1 more source
PERK Signaling Controls Myoblast Differentiation by Regulating MicroRNA Networks
Frontiers in Cell and Developmental Biology, 2021 The unfolded protein response (UPR) plays important roles in various cells that have a high demand for protein folding, which are involved in the process of cell differentiation and development.
Ye-Ya Tan +10 more
doaj +1 more source