Bidirectional Myoblast-Pericyte Plasticity [PDF]
Developmental Cell, 2013 Microvascular pericytes are able to generate multiple mesenchymal cell types, including skeletal muscle myoblasts. Cappellari et al. (2013) report in this issue of Developmental Cell that myoblasts can return the favor by generating pericytes via the action of Dll4 Notch ligand and PDGF-BB.
openaire +2 more sources
CRISPR/Cas9-induced (CTG⋅CAG)n repeat instability in the myotonic dystrophy type 1 locus: implications for therapeutic genome editing [PDF]
, 2017 Myotonic dystrophy type 1 (DM1) is caused by (CTG⋅CAG)n-repeat expansion within the DMPK gene and thought to be mediated by a toxic RNA gain of function.
André, Laurène M. +11 more
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Smad7:β-catenin Complex Regulates Myogenic Gene Transcription [PDF]
, 2019 Recent reports indicate that Smad7 promotes skeletal muscle differentiation and growth. We previously documented a non-canonical role of nuclear Smad7 during myogenesis, independent of its role in TGF-β signaling.
McDermott, John +2 more
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Profound effect of profiling platform and normalization strategy on detection of differentially expressed microRNAs [PDF]
, 2012 Adequate normalization minimizes the effects of systematic technical variations and is a prerequisite for getting meaningful biological changes. However, there is inconsistency about miRNA normalization performances and recommendations.
Kaiser, Sebastian +4 more
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Crosstalk Between Innate and T Cell Adaptive Immunity With(in) the Muscle
Frontiers in Physiology, 2020 Growing evidence demonstrates a continuous interaction between the immune system and the skeletal muscle in inflammatory diseases of different pathogenetic origins, in dystrophic conditions such as Duchenne Muscular Dystrophy as well as during normal ...
Adriana C. Bonomo +14 more
doaj +1 more source
Molecular Therapy: Methods & Clinical Development, 2022 Duchenne muscular dystrophy (DMD) is a muscle wasting disorder caused by mutations in the DMD gene. Restoration of full-length dystrophin protein in skeletal muscle would have therapeutic benefit, but lentivirally mediated delivery of such a large gene ...
Jinhong Meng +5 more
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New perspectives to repair a broken heart [PDF]
, 2009 The aim of cardiac cell therapy is to restore at least in part the functionality of the diseased or injured myocardium by the use of stem/ progenitor cells.
BARILE, Lucio +9 more
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PERK Signaling Controls Myoblast Differentiation by Regulating MicroRNA Networks
Frontiers in Cell and Developmental Biology, 2021 The unfolded protein response (UPR) plays important roles in various cells that have a high demand for protein folding, which are involved in the process of cell differentiation and development.
Ye-Ya Tan +10 more
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Fibroblasts derived from long-lived insulin receptor substrate 1 null mice are not resistant to multiple forms of stress [PDF]
, 2014 Reduced signalling through the insulin/insulin-like growth factor-1 signalling (IIS) pathway is a highly conserved lifespan determinant in model organisms.
Page, Melissa M. +5 more
core +1 more source
Expression profiling by high-throughput sequencing reveals GADD45, SMAD7, EGR-1 and HOXA3 activation in Myostatin (MSTN) and GDF11 treated myoblasts [PDF]
Genetics and Molecular BiologyGrowth differentiation factor 11 (GDF11) and myostatin (MSTN/GDF8) are closely related members of the transforming growth factor β (TGFβ) superfamily, sharing structural homology.
Platon Braun +4 more
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