Results 51 to 60 of about 79,103 (214)

Pancreatic cancer-associated diabetes mellitus: an open field for proteomic applications. [PDF]

, 2005
Background: Diabetes mellitus is associated with pancreatic cancer in more than 80% of the cases. Clinical, epidemiological, and experimental data indicate that pancreatic cancer causes diabetes mellitus by releasing soluble mediators which interfere ...
BALDO G, BASSO D, FLAGIELLO A, FOGAR P, GIUNCO S, GRECO E, NAVAGLIA F, PEDRAZZOLI S, PLEBANI M., PUCCI, PIETRO, VALERIO A, ZAMBON CF   +11 more
core   +1 more source

Trypanosoma cruzi Promotes Transcriptomic Remodeling of the JAK/STAT Signaling and Cell Cycle Pathways in Myoblasts

Frontiers in Cellular and Infection Microbiology, 2020
Chagas disease is responsible for more than 10,000 deaths per year and about 6 to 7 million infected people worldwide. In its chronic stage, patients can develop mega-colon, mega-esophagus, and cardiomyopathy.
Lindice M. Nisimura, Laura L. Coelho, Tatiana G. de Melo, Paloma de Carvalho Vieira, Pedro H. Victorino, Luciana R. Garzoni, David C. Spray, Dumitru A. Iacobas, Sanda Iacobas, Herbert B. Tanowitz, Daniel Adesse   +10 more
doaj   +1 more source

Membrane glucocorticoid receptors are localised in the extracellular matrix and signal through the MAPK pathway in mammalian skeletal muscle fibres [PDF]

, 2015
A number of studies have previously proposed the existence of glucocorticoid receptors on the plasma membrane of many cell types including skeletal muscle fibres.
Dietmar Steverding, Eugene Akujuru, Feliciano Protasi, Gabriel Mutungi, Goldberg AL, Lewis Arthurton, Simona Boncompagni, Timothy Pearson, Wing SS   +8 more
core   +1 more source

Engineering muscle networks in 3D gelatin methacryloyl hydrogels: influence of mechanical stiffness and geometrical confinement [PDF]

, 2017
In this work, the influence of mechanical stiffness and geometrical confinement on the 3D culture of myoblast-laden gelatin methacryloyl (GelMA) photo-crosslinkable hydrogels was evaluated in terms of in vitro myogenesis.
Barbetta, Andrea, Costantini, Marco, Fornetti, Ersilia, Gargioli, Cesare, Maria Cannata, Stefano, Rainer, Alberto, Testa, Stefano, Trombetta, Marcella   +7 more
core   +1 more source

The Non-Linear Profile of Aging: U-Shaped Expression of Myostatin, Follistatin and Intermediate Signals in a Longitudinal In Vitro Murine Cell Sarcopenia Model

Proteomes
Sarcopenia is linked to the decline in muscle mass, strength and function during aging. It affects the quality and life expectancy and can lead to dependence.
Janire Alonso-Puyo, Oihane Izagirre-Fernandez, Olatz Crende, Jesús Seco-Calvo, Ainhoa Fernandez-Atutxa, Diego Fernandez-Lazaro, Patricia Garcia-Gallastegi, Begoña Sanz   +7 more
doaj   +1 more source

The action of obestatin in skeletal muscle repair: stem cell expansion, muscle growth, and microenvironment remodeling [PDF]

, 2015
The development of therapeutic strategies for skeletal muscle diseases, such as physical injuries and myopathies, depends on the knowledge of regulatory signals that control the myogenic process. The obestatin/GPR39 system operates as an autocrine signal
ADAMO, Sergio, C. S. Mosteiro, D. l. Beiroa, F. F. Casanueva, I. Santos Zas, J. E. Viñuela, J. González Sánchez, J. M. Renaud, J. P. Camiña, J. Señarís, MORESI, Viviana, R. Gallego, R. Nogueiras, T. García Caballero, U. Gurriarán Rodríguez, W. Lin, Y. Pazos   +16 more
core   +1 more source

Depletion of Branched-Chain Aminotransferase 2 (BCAT2) Enzyme Impairs Myoblast 3 Survival and Myotube Formation [PDF]

, 2019
Much is known about the positive effects of branched-chain amino acids (BCAA) in regulating muscle protein metabolism. Comparatively much less is known about the effects of these amino acids and their metabolites in regulating myotube formation.
ADEGOKE, OLASUNKANMI, Dhanani, Zameer N., Mann, Gagandeep   +2 more
core  

lncRNA IGF2 AS Regulates Bovine Myogenesis through Different Pathways

Molecular Therapy: Nucleic Acids, 2020
The role of long non-coding RNA (lncRNA) in the regulation of bovine skeletal muscle development remains poorly understood. The present study investigated the function and regulatory mechanism of a novel lncRNA, insulin-like growth factor 2 antisense ...
Chengchuang Song, Zhaoxin Yang, Rui Jiang, Jie Cheng, Binglin Yue, Jian Wang, Xiaomei Sun, Yongzhen Huang, Xianyong Lan, Chuzhao Lei, Hong Chen   +10 more
doaj   +1 more source

Thermal stress induces glycolytic beige fat formation via a myogenic state. [PDF]

, 2019
Environmental cues profoundly affect cellular plasticity in multicellular organisms. For instance, exercise promotes a glycolytic-to-oxidative fibre-type switch in skeletal muscle, and cold acclimation induces beige adipocyte biogenesis in adipose tissue.
A Jaworski, AA Lans van der, Andrew Brack, Annarita Scaramozza, C Trapnell, Carlos Henrique Sponton, DC Berry, ES Bachman, H Ohno, J Nedergaard, J Sanchez-Gurmaches, J Wu, JR Arch, JZ Long, K Ikeda, K Nishijo, K Shinoda, Kazuki Tajima, Kenji Ikeda, Kosaku Shinoda, Kyeongkyu Kim, L Kazak, L Vishvanath, L Ye, LZ Sharp, M Razzoli, ME Lidell, MJ Hanssen, ML Gantner, MS Rodeheffer, P Cohen, P Seale, Qiang Wang, S Collins, S Heinz, S Jung, S Kajimura, S Tripathi, Shingo Kajimura, T Buch, T Yoneshiro, Takeshi Yoneshiro, VK Mootha, Y Hasegawa, YH Lee, YH Tseng, Yong Chen, Zachary Brown, ZF Yang   +48 more
core   +2 more sources

The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis [PDF]

, 2019
Post-transcriptional mechanisms have the potential to influence complex changes in gene expression, yet their role in cell fate transitions remains largely unexplored.
Aigner, S., Anselmo, A., Brumbaugh, J., Charlton, J., Clement, K., Clowers, K., de Kort, M., Di Stefano, B., Gerli, M., Gu, H., Gygi, S., Haggerty, C., Hochedlinger, K., Huebner, A., Ji, F., Lipchina, I., Luo, E., Meissner, A., Pulice, J., Rabano Jiménez, I., Sadreyev, R., Yeo, G.   +21 more
core   +3 more sources