Results 51 to 60 of about 43,612 (265)

Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery

Advanced Science, EarlyView.
Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae, Jisun Lee, Jae‐Hun Ahn, Hosam Choi, Huijeong Choi, Jungmin Kim, Minho Kang, Ho Rim Oh, So Hyun Park, Eun Young Oh, Sanghyuk Jeon, Yeeun Lee, Yu‐Sun Lee, Na‐Young Lee, Hee‐Jin Bae, Jina Kwak, Jooil Kim, Nakyung Lee, Beomsun Kang, Ji‐Hye Kim, Eunsaem Song, Daesub Song, Hyunho Yoon, Sang‐Myeong Lee, Hyewon Youn, Kiyoun Lee, Byeong‐Cheol Kang, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Development of a multifunctional bioreactor to evaluate the promotion effects of cyclic stretching and electrical stimulation on muscle differentiation

Bioengineering & Translational Medicine
A multifunctional bioreactor was fabricated in this study to investigate the facilitation efficiency of electrical and mechanical stimulations on myogenic differentiation.
Wei‐Wen Hu, Yen‐Chi Chen, Chia‐Wen Tsao, Shen‐Liang Chen, Chung‐Yuh Tzeng   +4 more
doaj   +1 more source

Controlling Self‐Doping in Conjugated Polyelectrolyte Copolymers to Vary the Threshold Voltage in OECTs

Advanced Electronic Materials, EarlyView.
Two series of self‐doped conjugated polyelectrolytes are synthesized from a non‐self‐dopable building block 3MEEET and a self‐dopable building‐block 3HOT−[TMA+] or 3HOT−[SO3H] enabling precise control over the degree of self‐doping, which in turn directly governs the threshold voltage (VT) in OECTs over a wide range of 700 mV.
Julian Hungenberg, Andreas W. Erhardt, Adrian Hochgesang, John Mohanraj, Lys Sprenger, Sahar Salehi, Christopher R. McNeill, Mukundan Thelakkat   +7 more
wiley   +1 more source

Micro‐Scale Topography Triggers Dynamic 3D Nuclear Deformations

Advanced Science
Navigating complex extracellular environments requires extensive deformation of cells and their nuclei. Most in vitro systems used to study nuclear deformations impose whole‐cell confinement that mimics the physical crowding experienced by cells during ...
Claire Leclech, Giulia Cardillo, Bettina Roellinger, Xingjian Zhang, Joni Frederick, Kamel Mamchaoui, Catherine Coirault, Abdul I. Barakat   +7 more
doaj   +1 more source

Interaction between mouse macrophages RAW264.7 and myoblasts C2C12 in a co-culture system

Di-san junyi daxue xuebao, 2019
Objective To establish a co-culture system to observe the interactions between mouse macrophage RAW264.7 and myoblast C2C12 cells. Methods RAW264.7 and C2C12 cell lines were co-cultured in a Transwell chamber containing conditioned medium for myogenic ...
LUO We, LUO We, LI Xian, WANG Bofa, AI Lei, ZHOU Yue   +5 more
doaj   +1 more source

Effectiveness of intermittent hypoxia on muscle recovery in rats: A systematic review

Animal Models and Experimental Medicine, EarlyView.
This systematic review of animal studies evaluated intermittent hypobaric hypoxia (IHH), cold exposure, and their combinations, with or without exercise, on skeletal muscle recovery. IHH enhanced muscle regeneration, reduced fibrosis, improved contractile force, and maintained oxidative capacity, while cold exposure increased mitochondrial activity but
Sebastian Philippe Hansen Quiblier, María García‐Arrabé, Diego Domínguez‐Balmaseda, Guillermo García‐Pérez‐de‐Sevilla   +3 more
wiley   +1 more source

Myoblast Choreographic Alignment

ACS Nano
The alignment of spindle-shaped cells is crucial for physiological processes, such as muscle regeneration and tissue engineering. Despite their importance, the underlying mechanisms that govern this alignment remain poorly understood. In this study, we explore the collective motion and alignment of C2C12 myoblasts, cells essential for muscle ...
Yucheng Huo, Hongmei Xu, Yukai Zhao, Endao Han, Marcus Lin, K. Jimmy Hsia   +5 more
openaire   +3 more sources

LncRSFD Alternative Splicing Modulates the Proliferation and Differentiation of Adipocytes Through Sponging miRNAs

Animal Research and One Health, EarlyView.
This study identified a molecule named lncRSFD, which is highly expressed in sheep adipose tissues. The lncRSFD gene generates two distinct transcript variants via alternative splicing: lncRSFD‐L and lncRSFD‐S. Functionally, lncRSFD alternative splicing (lncRSFD‐L/S) promotes the proliferation, differentiation, and lipid metabolism of adipocytes ...
Jinpeng Wang, Qiuyang Li, Zhiying Wang, Shan Zhang, Kassahun Bekana, Qingfeng Zhang, Juanshan Zheng, Hongwei Xu, Xianyong Lan, Chuanying Pan   +9 more
wiley   +1 more source

Analysis of platelet-derived growth factor receptor alpha expression in adult mouse testis

Journal of Animal Reproduction and Biotechnology
Background: Platelet-derived growth factor receptor alpha (PDGFRα) is essential for various biological processes, including fetal Leydig cell differentiation.
Min Seok Woo, Eun-Jin Kim, Dong Kun Lee, Chung Eun Lee, Eun-A Ko, Dawon Kang   +5 more
doaj   +1 more source

The Drosophila FUS ortholog cabeza promotes adult founder myoblast selection by Xrp1-dependent regulation of FGF signaling.

PLoS Genetics, 2020
The number of adult myofibers in Drosophila is determined by the number of founder myoblasts selected from a myoblast pool, a process governed by fibroblast growth factor (FGF) signaling.
Marica Catinozzi, Moushami Mallik, Marie Frickenhaus, Marije Been, Céline Sijlmans, Divita Kulshrestha, Ioannis Alexopoulos, Manuela Weitkunat, Frank Schnorrer, Erik Storkebaum   +9 more
doaj   +1 more source