Results 111 to 120 of about 32,619 (226)

Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse

Experimental Physiology, EarlyView.
Abstract Skeletal muscle plays an important role in whole‐body health, quality of life and regulation of metabolism. The maintenance of a healthy mitochondrial pool is imperative for the preservation of skeletal muscle quality and is mediated through mitochondrial quality control consisting of mitochondrial turnover mediated by a balance between ...
Anastasiya Kuznyetsova, David A. Hood
wiley   +1 more source

Effect of hypokinesia on contractile function of cardiac muscle [PDF]

Rats were subjected to hypokinesia for two months and the contractile function of isolated papillary muscle was studied. Hypokinesia reduced significantly the isotonic contraction rate which depended on the ATPase activity of the myofibrils; it also ...
Gorina, M. S., Kapelko, V. I., Meyerson, F. Z., Trikhpoyeva, A. M.   +3 more
core   +1 more source

Determinants of maximal oxygen uptake in highly trained females and males: a mechanistic study of sex differences using advanced invasive methods

The Journal of Physiology, EarlyView.
Abstract figure legend The results from this study show that maximal cardiac output, stroke volume and leg blood flow are similar between highly trained females and males after normalisation to lean body mass (LBM). However, the 10% higher haemoglobin concentration ([Hb]) and arterial O2 content in males result in higher systemic and leg O2 delivery ...
Øyvind Skattebo, Marcos Martin‐Rincon, Bjarne Rud, Joachim Nielsen, Lars Henrik N. Hegg, Andreas V. Kleive, Niels Ørtenblad, Øyvind Sandbakk, Robert Boushel, Hans‐Christer Holmberg, Jose A.L. Calbet, Jostein Hallén   +11 more
wiley   +1 more source

Electron microscopical and histochemical studies on the transverse striated muscles of birds after prolonged hypokinesis [PDF]

Studies of the gastrocnemius muscle were carried out in 4 month old cockerels of the laying hybrid after hypokinesis lasting 15 and 30 days. It was found that restricted movement resulted in dystrophic changes of myotibrils, enlargement of the ...
Belak, M., Boda, K., Kocisova, J., Marcanik, J., Skarda, R.   +4 more
core   +1 more source

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

Mechanical characterization of skeletal muscle myofibrils

Biophysical Journal, 1996
A new instrument, based on a technique described previously, is presented for studying mechanics of micron-scale preparations of two to three myofibrils or single myofibrils from muscle. Forces in the nanonewton to micronewton range are measurable with 0.5-ms time resolution.
Friedman, A.L., Goldman, Y.E.
openaire   +2 more sources

Human‐derived cardiac‐neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li, Chenchen Zhang, Mengying Xu, YoonYoung Choi, Davi Sidarta‐Oliveira, Ruirui Dong, Xinyu Hu, Enrique M. Toledo, Cesar A. Prada‐Medina, Finbar Argus, Kun Liu, Mingyu Li, Linna Zhou, Hagan Bayley, Corey Smith, Chris Denning, Ana I. Domingos, Guoliang Hao, Dan Li, David J. Paterson   +19 more
wiley   +1 more source

Arginylation of Myosin Heavy Chain Regulates Skeletal Muscle Strength

Cell Reports, 2014
Protein arginylation is a posttranslational modification with an emerging global role in the regulation of actin cytoskeleton. To test the role of arginylation in the skeletal muscle, we generated a mouse model with Ate1 deletion driven by the skeletal ...
Anabelle S. Cornachione, Felipe S. Leite, Junling Wang, Nicolae A. Leu, Albert Kalganov, Denys Volgin, Xuemei Han, Tao Xu, Yu-Shu Cheng, John R.R. Yates III, Dilson E. Rassier, Anna Kashina   +11 more
doaj   +1 more source

The effect of complex training on horizontal power production in rugby union players : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science at Massey University [PDF]

, 2004
The use of strength and power training regimes is common place among elite and recreational athletes. However, the application of such methods as direct determinants of improvement in sporting performance is a controversial and much debated topic because
Graham, David Fraser
core  

Variant Update on ASCC1 : Characterization of the First Homozygous Missense Variant Involved in Prenatal‐Onset Spinal Muscular Atrophy With Congenital Bone Fractures 2

American Journal of Medical Genetics Part A, Volume 200, Issue 3, Page 744-748, March 2026.
ABSTRACT Spinal muscular atrophy with congenital bone fractures 2 is a rare and severe autosomal recessive neuromuscular disorder caused by pathogenic variants in ASCC1. This condition characterized by prenatal onset of severe hypotonia with fetal hypokinesia and congenital contractures results in arthrogryposis multiplex congenita, and increased ...
A. Civit, L. Kerbellec, D. Laurenceau, D. C. Ung, M. P. Moizard, N. Ronce, P. Gueguen, F. Laumonnier, A. C. Bréhin, F. Marguet, A. Laquerrière, A. M. Bergemer Fouquet, J. Cirier, S. Blesson, S. Arpin, M. Jeanne, M. L. Vuillaume   +16 more
wiley   +1 more source