Results 131 to 140 of about 32,565 (245)

Bidirectional Relationship and Shared Mechanisms Between Sarcopenia and Osteoporosis: An Observational Study Integrating Genomic, Proteomic, and Metabolomic Data

open access: yesAging Cell, Volume 25, Issue 7, July 2026.
This study investigated the bidirectional relationship and shared mechanisms between sarcopenia and osteoporosis using data from the UK Biobank. Our findings indicated that the two conditions may act as reciprocal risk factors, with multiple potential biomarkers mediating the muscle‐bone relationship and suggested possible shared signals between the ...
Siqi Xu   +10 more
wiley   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

open access: yesThe FEBS Journal, Volume 293, Issue 13, Page 3717-3757, July 2026.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou   +4 more
wiley   +1 more source

Genomic Analysis of Inbreeding Depression on Productive Traits in Rubia Galega Beef Cattle Breed

open access: yesJournal of Animal Breeding and Genetics, Volume 143, Issue 4, Page 508-523, July 2026.
ABSTRACT In autochthonous livestock breeds with small populations, such as the Rubia Galega from Galicia (Spain), mating between relatives is common and can lead to inbreeding depression. Genomic inbreeding coefficients were estimated for 4984 animals using ~63,000 SNPs to assess inbreeding depression in four key traits: age at first calving (AFC) with
N. Mejuto‐Vázquez   +6 more
wiley   +1 more source

Additional file 4: Figure S3. of Nilotinib impairs skeletal myogenesis by increasing myoblast proliferation

open access: yes, 2018
p38, ERK1/2, and AKT phosphorylation during C2C12 skeletal myogenesis. (A) Representative Western blots evaluating the phosphorylation of p38, ERK1/2, and AKT during a 6-day time curse of skeletal myogenesis using the C2C12 myoblast cell line.
Osvaldo Contreras (780538)   +2 more
core   +1 more source

Multi‐Omics Landscape of Paraspinal Muscles in Spinal Muscular Atrophy With Scoliosis

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.
ABSTRACT Most spinal muscular atrophy (SMA) patients develop severe scoliosis by late adolescence. Given that the paraspinal muscles—particularly the multifidus—are indispensable for maintaining spinal stability, their site‐specific multi‐omics characteristics in SMA remain insufficiently defined. Herein, integrated multi‐omics sequencing was performed
Zhen Wang   +4 more
wiley   +1 more source

Unorthodox myogenesis, possi ble developmental significance and implications for tissue histogenesis and regeneration [PDF]

open access: yes, 1997
During the last few years several reports have described the occurrence of skeletal myogenesis in cells derived from embryonic, fetal and perinatal tissues that usually do not contribute to skeletal muscle in the adult vertebrate body. After a brief
Cossu, G.
core  

Bovine myoblast stimulation for enhancing myogenesis

open access: yes
Introduction: Several challenges account for the slow progress of cultured meat production. Primary bovine muscle stem cells have limited cell growth and lose their myogenic differentiation capacity to myotubes after expansion and the resulting myotubes ...
Deelkens, Chloë, Thorrez, Lieven
core  

UNDERSTANDING THE ROLE OF TBX3 IN MYOGENESIS

open access: yes, 2017
Myogenesis, the formation of muscular tissues, requires the precise expression of myogenic regulatory factors (MRFs), whose expression regulates transcription of muscle specific genes. TBX3 is a member of the T-box family of transcription factors that is
ALTHOBAITI, AIYSHA NASSER
core  

FUNCTION OF AMP-ACTIVATED PROTEIN KINASE IN MYOGENESIS

open access: yes, 2015
Thesis (Ph.D.), Washington State UniversityProper skeletal muscle development is crucial for human health and meat production. AMPK is the master metabolism regulator, but the role of AMPK in myogenesis remains poorly defined. Previous studies using AMPK
Fu, Xing
core  

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