Results 101 to 110 of about 1,662 (193)

Maternal exercise improves vascular function in hypertensive offspring via A‐kinase anchoring protein 150 gene (Akap5) epigenetic modifications

British Journal of Pharmacology, EarlyView.
Background and Purpose Regular physical activity is an effective non‐pharmacological approach to hypertension management and maternal exercise improves offspring cardiovascular health, although mechanisms remain unclear. A‐kinase anchoring protein 150 (AKAP150) targets protein kinase Cα to L‐type Ca2+ channels (CaV1.2), enhancing vascular tone in ...
Fang Qiu, Yanyan Zhang, Meiling Shan, Jiaqi Cao, Zihan Fan, Zhaoxia Xu, Xiaozhen Ding, Xiaodong Liu, Lijun Shi   +8 more
wiley   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

The Anti-Myogenic Role of Tetranectin and Its Inhibition by Epigallocatechin-3-Gallate Enhances Myogenesis

Cells
Tetranectin (TN) is a plasminogen-binding protein found in human serum. Although it has been suggested to be closely related to various stem cell differentiation, including myogenesis, the role of TN in muscle development remains unclear.
Amar Akash, Jihoe Kim
doaj   +1 more source

LCN2‐ACOD1 Signalling Affects the Post‐Injury Regeneration of Skeletal Muscle Through Mediating Ferroptosis

Cell Proliferation, EarlyView.
LCN2 mediates the suppression of C2C12 myoblast proliferation and myotube formation via erastin‐induced ferroptosis. Mechanistically, the LCN2‐ACOD1 axis regulates skeletal muscle growth via mitochondria‐associated ferroptosis, providing a theoretical basis for the prevention and therapy of muscle‐related diseases.
Xiaojing Hao, Hongwei Shi, Di Wu, Rui Liang, Tong Zhao, Wen Sun, Yue Wang, Xiuju Yu, Xiaomao Luo, Yi Yan, Jiayin Lu, Haidong Wang, Juan Wang   +12 more
wiley   +1 more source

Mechanobiology in Stem Cell‐Based Bioprinting

Cell Proliferation, EarlyView.
Mechanobiology in stem cell‐based bioprinting is an emerging field that bridges the mechanical conditions of the bioprinting process with the regulation of stem cell behaviour for engineering living tissues. Stresses encountered during bioprinting, together with the mechanical properties of bioinks, play a critical role in regulating stem cell ...
Supeng Ding, Tiankun Liu, Rui Yao
wiley   +1 more source

Treatment approaches in posthypoxic myoclonus: A narrative review with expert opinion

Epilepsia, EarlyView.
Abstract Acute posthypoxic myoclonus (PHM) is a neurological complication that typically emerges within 12–48 h following cardiac arrest, often in comatose patients. It can present as generalized, multifocal, or focal myoclonus and has traditionally been associated with poor prognosis.
Marina Romozzi, Federico Tosto, David García‐Azorín, Luigi Francesco Iannone, Catello Vollono, Paolo Calabresi, Juan Luis Alcala‐Zermeno, Michael R. Sperling   +7 more
wiley   +1 more source

Resistance‐exercise‐induced stress intervenes in TGF‐β signaling by cooperatively downregulating nuclear αB‐crystallin and SMAD4 in human skeletal muscle fibers

The FEBS Journal, EarlyView.
Alpha‐crystallin B chain (CRYAB) has been reported to stabilize mothers against decapentaplegic homolog 4 (SMAD4) in transforming growth factor‐β (TGF‐β) signaling, enabling target gene transcription. We show nuclear CRYAB–SMAD4 interaction for the first time in human skeletal muscle fibers and its regulation by exercise.
Kirill Schaaf, Cassandra Duda, Tihomir Kostov, Patrick Diel, Käthe Bersiner, Wilhelm Bloch, Sebastian Gehlert, Daniel Jacko   +7 more
wiley   +1 more source

Overexpression of syndecan-4 inhibits myogenesis by regulating the expression of myogenic regulatory factors

Journal of Animal Science and Technology
Syndecan-4, a type of heparin sulfate proteoglycan, plays an important role in muscle development, regeneration, and maintenance. Although, the important effects of syndecan-4 on the regulation of myogenesis in mice, turkeys, and bovines have been ...
Sarang Choi, Jeong-Woong Park, Sang In Lee, Sangsu Shin   +3 more
doaj   +1 more source

Ossifying spindled and epithelioid tumour: Expanding the clinical and morphologic spectrum of a recently described entity

Histopathology, EarlyView.
Ossifying spindled and epithelioid tumour (OSET) can show unusual morphologic features, including minimal or absent peripheral ossification, eosinophil‐rich stroma, increased mitotic activity (≥5 mitotic figures per 10 high‐power fields), and necrosis.
Rayan M Sibira, Benjamin F Smith, Amy Davis, Jessica L Davis, Nada Mohamed, Riyam Zreik, David J Papke Jr., Michael Michal, Sintawat Wangsiricharoen, Karen J Fritchie   +9 more
wiley   +1 more source

The Effect of Vitamin D3 Supplementation on the Risk of Falls in a General Population—The Finnish Vitamin D Trial

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background The impact of vitamin D on fall incidence remains controversial. We studied the effect of 5 years of vitamin D3 supplementation on the risk of falls in a double‐blind, placebo‐controlled randomized trial with generally healthy, community‐dwelling men and women in Finland.
Toni Rikkonen, Sari Hantunen, Heikki Kröger, Christel Lamberg‐Allardt, JoAnn E. Manson, Tarja Nurmi, Marjo Tuppurainen, Ari Voutilainen, Tomi‐Pekka Tuomainen, Jyrki K. Virtanen   +9 more
wiley   +1 more source