Results 61 to 70 of about 2,964 (225)

Pharmacological Properties of Vochysia Haenkeana (Vochysiaceae) Extract to Neutralize the Neuromuscular Blockade Induced by Bothropstoxin-I (Lys49 Phospholipase A2) Myotoxin [PDF]

Advanced Pharmaceutical Bulletin, 2017
Purpose: Bothrops snakes are responsible for more than 70 % of snakebites every year in Brazil and their venoms cause severe local and systemic damages. The pharmacological properties of medicinal plants have been widely investigated in order to discover
Carolina Harder, Akila Lara de Oliveira, Andreia Borges Scriboni, Adélia Cristina Oliveira Cintra, Raphael Schezaro-Ramos, Márcio Galdino dos Santos, Karina Cogo-Müller, Regina Yuri Hashimoto Miura, Rafael Stuani Floriano, Sandro Rostelato-Ferreira, Yoko Oshima-Franco   +10 more
doaj   +1 more source

POTENTIAL ANTIDOTE TO SNAKE VENOM MYOTOXIN [PDF]

Journal of Experimental Biology, 2012
![][1] Snakebites are frequently hazardous accidents that require immediate medical treatment to neutralize the venom’s toxic effects. A feared complication of South American pit viper bites is extended myonecrosis, i.e.
openaire   +1 more source

Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A2: activation of endogenous phospholipases contributes to the pronociceptive effect

Journal of Venomous Animals and Toxins including Tropical Diseases, 2017
Background Arthritis is a set of inflammatory conditions that induce aching, stiffness, swelling, pain and may cause functional disability with severe consequences to the patient’s lives.
Renata Gonçalves Dias, Sandra Coccuzzo Sampaio, Morena Brazil Sant’Anna, Fernando Queiroz Cunha, José María Gutiérrez, Bruno Lomonte, Yara Cury, Gisele Picolo   +7 more
doaj   +1 more source

Crotalus ruber [PDF]

, 2006
Number of Pages: 17Integrative BiologyGeological ...
Beaman, Kent R., Dugan, Eric A.
core   +1 more source

Corn Cultivation to Reduce the Mycotoxin Contamination

Research in Plant Disease, 2017
The effects of insecticide and fungicide treatment were investigated to reduce mycotoxin contamination of corn (Zea mays L.) seeds. Deoxynivalenol and zearalenone contents were reduced in the treated seeds, but aflatoxin, ochratoxin A, fumonisin, and T-2
Yangseon Kim, In Jeong Kang, Dong Bum Shin, Jae Hwan Roh, Jingyo Jung, Sunggi Heu, Hyeong Kwon Shim   +6 more
doaj   +1 more source

Structural and functional evidence for membrane docking and disruption sites on phospholipase A2-like proteins revealed by complexation with the inhibitor suramin [PDF]

, 2017
Local myonecrosis resulting from snakebite envenomation is not efficiently neutralized by regular antivenom administration. This limitation is considered to be a significant health problem by the World Health Organization.
Cavalcante, W. L. G., Dreyer, Thiago R., Fontes, M.R.M., Gallacci, M., Matioli, F. F., Salvador, G. H. M., Santos, J. I. dos, Velázquez-Campoy, Adrián   +7 more
core   +1 more source

Grafting of a single donor myofibre promotes hypertrophy in dystrophic mouse muscle.

PLoS ONE, 2013
Skeletal muscle has a remarkable capability of regeneration following injury. Satellite cells, the principal muscle stem cells, are responsible for this process.
Luisa Boldrin, Jennifer E Morgan
doaj   +1 more source

Isolation and structural characterization of bioactive compound from Aristolochia sprucei aqueous extract with anti-myotoxic activity

Toxicon: X, 2020
A bioactive compound isolated from the stem extract of Aristolochia sprucei through High Performance Liquid Chromatography (HPLC) was identified via Nuclear Magnetic Resonance (NMR) as the aristolochic acid (AA). This compound showed an inhibitory effect
Isela I. González Rodríguez, Aleff F. Francisco, Leandro S. Moreira-Dill, Aristides Quintero, César L.S. Guimarães, Carlos A.H. Fernandes, Agnes A.S. Takeda, Fernando B. Zanchi, Cléopatra A.S. Caldeira, Paulo S. Pereira, Marcos R.M. Fontes, Juliana P. Zuliani, Andreimar M. Soares   +12 more
doaj   +1 more source

Inhibition of the Myotoxicity Induced by Bothrops jararacussu Venom and Isolated Phospholipases A2 by Specific Camelid Single-Domain Antibody Fragments. [PDF]

PLoS ONE, 2016
Antivenoms, produced using animal hyperimmune plasma, remains the standard therapy for snakebites. Although effective against systemic damages, conventional antivenoms have limited efficacy against local tissue damage.
Nidiane D R Prado, Soraya S Pereira, Michele P da Silva, Michelle S S Morais, Anderson M Kayano, Leandro S Moreira-Dill, Marcos B Luiz, Fernando B Zanchi, André L Fuly, Maribel E F Huacca, Cleberson F Fernandes, Leonardo A Calderon, Juliana P Zuliani, Luiz H Pereira da Silva, Andreimar M Soares, Rodrigo G Stabeli, Carla F C Fernandes   +16 more
doaj   +1 more source

State of the Art in the Studies on Crotamine, a Cell Penetrating Peptide from South American Rattlesnake [PDF]

, 2014
Animal venoms comprise a naturally selected cocktail of bioactive peptides/proteins and other molecules, each of which playing a defined role thanks to the highly specific interactions with diverse molecular targets found in the prey. Research focused on
De Sa Junior, Paulo Luiz, Hayashi, Mirian A. F., Kerkis, Alexandre, Kerkis, Irina, Pereira, Alexandre, Prieto da Silva, Alvaro R. B., Radis-Baptista, Gandhi, Yamane, Tetsuo, Zaharenko, Andre J.   +8 more
core   +2 more sources