Results 71 to 80 of about 2,964 (225)

Computational Studies of Snake Venom Toxins

Toxins, 2017
Most snake venom toxins are proteins, and participate to envenomation through a diverse array of bioactivities, such as bleeding, inflammation, and pain, cytotoxic, cardiotoxic or neurotoxic effects.
Paola G. Ojeda, David Ramírez, Jans Alzate-Morales, Julio Caballero, Quentin Kaas, Wendy González   +5 more
doaj   +1 more source

Melatonin Activates AMPK Pathway to Regulate the Regeneration of Slow Muscle Fibers in Skeletal Muscle Injury Repair

The FASEB Journal, Volume 39, Issue 20, 31 October 2025.
The figure illustrates in vitro (melatonin‐treated C2C12 myoblasts) and in vivo (mouse frostbite‐induced tibialis anterior muscle injury with melatonin administration) models. Melatonin activates AMPK, which phosphorylates PGC‐1α to enhance mitochondrial bioenergetics (decreased ROS and LDH, increased ATP, mtDNA, membrane potential, and oxygen ...
Wei Xie, Zhengchao Hong, Yuxin Xie, Kangyan Hou, Songhan Li, Mingxin Fang, Yupeng Guan, Zhixuan Zhang, Miao Zhang   +8 more
wiley   +1 more source

Geographic variation in the clinical features of Mohave rattlesnake (Crotalus scutulatus) envenomations reported to the North American Snakebite Registry

Toxicon: X
The geographic variation of Mohave rattlesnake (Crotalus scutulatus) venom is well established. We reviewed all the Mohave rattlesnake bites reported to the Toxicology Investigators Consortium's North American Snakebite Registry between January 1, 2015 ...
Spencer Greene, Matthew Gilbert, Brian Wolk, Sharan Campleman, Anne-Michelle Ruha   +4 more
doaj   +1 more source

Environmental conditions and host plant origin override endophyte effects on invertebrate communities [PDF]

, 2011
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Faeth, Stanley H., Helander, Marjo, Hyvönen, Terho, Saikkonen, Kari, Vesterlund, Salla-Riikka   +4 more
core   +1 more source

Antitumor potential of the myotoxin BthTX-I from Bothrops jararacussu snake venom: evaluation of cell cycle alterations and death mechanisms induced in tumor cell lines

Journal of Venomous Animals and Toxins including Tropical Diseases, 2015
Background Phospholipases A 2 (PLA 2 s) are abundant components of snake venoms that have been extensively studied due to their pharmacological and pathophysiological effects on living organisms.
Cássio Prinholato da Silva, Tássia R. Costa, Raquel M. Alves Paiva, Adélia C. O. Cintra, Danilo L. Menaldo, Lusânia M. Greggi Antunes, Suely V. Sampaio   +6 more
doaj   +1 more source

Regenerated soleus muscle shows reduced creatine kinase efflux after contractile activity in vitro [PDF]

, 2014
Date of Acceptance: 07/10/2014 Acknowledgements We are very grateful to Petras Jeneckas and Audrius Capskas for technical assistance. The study was supported by a grant (No.
Baltusnikas, Juozas, Fokin, Andrej, Kilikevicius, Audrius, Lionikas, Arimantas, Ratkevicius, Aivaras, Venckunas, Tomas   +5 more
core   +1 more source

Overexpression of enhanced yellow fluorescent protein fused with Channelrhodopsin‐2 causes contractile dysfunction in skeletal muscle

The FASEB Journal, Volume 38, Issue 22, 30 November 2024.
Optogenetic tools like Channelrhodpsin‐2 (ChR2) are useful for inducing skeletal muscle contraction using blue light. However, the prevalence of fluorescent proteins like EYFP may cause functional issues. Here, Lamia et al. showed that the contractile properties of ChR2‐EYFP skeletal muscle had aggregated EYFP in sarcolemma, decreased contractile force
Syeda N. Lamia, Carol S. Davis, Peter C. D. Macpherson, T. Brad Willingham, Yingfan Zhang, Chengyu Liu, Leanne Iannucci, Elahe Ganji, Desmond Harden, Iman Bhattacharya, Adam C. Abraham, Susan V. Brooks, Brian Glancy, Megan L. Killian   +13 more
wiley   +1 more source

Cigarette smoke exposure impairs early‐stage recovery from lengthening contraction‐induced muscle injury in male mice

Physiological Reports, Volume 12, Issue 18, September 2024.
Abstract The use of tobacco cigarettes produces locomotor muscle weakness and fatigue intolerance. Also, smokers and chronic obstructive pulmonary disease patients have a greater incidence of muscle injury and a deficient myogenic response. However, the effects of smoke exposure on the recovery from eccentric exercise‐induced muscle injuries are ...
Nicole E. Stevens, Mafalda Loreti, Israel Ramirez‐Sanchez, Felipe C. G. Dos Reis, Alessandra Sacco, Ellen C. Breen, Leonardo Nogueira   +6 more
wiley   +1 more source

Identification of presynaptic neurotoxin complexes in the venoms of three Australian copperheads (Austrelaps spp.) and the efficacy of tiger snake antivenom to prevent or reverse neurotoxicity [PDF]

, 2011
The venom of the Australian lowlands copperhead, Austrelaps superbus, produces significant and potentially lethal neurotoxic paralysis in cases of clinical envenomation. However, little is known about the neurotoxic components within this venom or venoms
Marcon, F, Nicholson, GM
core   +1 more source

Snake venom toxins: Potential anticancer therapeutics

Journal of Applied Toxicology, Volume 44, Issue 5, Page 666-685, May 2024.
Abstract Snake venom contains a cocktail of compounds dominated by proteins and peptides, which make up the toxin. The toxin components of snake venom attack several targets in the human body including the neuromuscular system, kidney and blood coagulation system and cause pathologies. As such, the venom toxins can be managed and used for the treatment
Benedict C. Offor, Lizelle A. Piater
wiley   +1 more source