Synthesis of N-Glycolylneuraminic Acid (Neu5Gc) and Its Glycosides [PDF]
Frontiers in Immunology, 2019 Sialic acids constitute a family of negatively charged structurally diverse monosaccharides that are commonly presented on the termini of glycans in higher animals and some microorganisms.
Anoopjit Singh Kooner, Hai Yu, Xi Chen
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N-glycolylneuraminic acid as a carbohydrate cancer biomarker [PDF]
Translational Oncology, 2023 One of the forms of aberrant glycosylation in human tumors is the expression of N-glycolylneuraminic acid (Neu5Gc). The only known enzyme to biosynthesize Neu5Gc in mammals, cytidine-5′-monophosphate-N-acetylneuraminic acid (CMAH), appears to be ...
Jing Wang +3 more
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Glycosylated Biotherapeutics: Immunological Effects of N-Glycolylneuraminic Acid [PDF]
Frontiers in Immunology, 2020 The emerging field of biotherapeutics provides successful treatments for various diseases, yet immunogenicity and limited efficacy remain major concerns for many products.
Sharon Yehuda, Vered Padler-Karavani
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N-Glycolylneuraminic Acid in Animal Models for Human Influenza A Virus [PDF]
Viruses, 2021 The first step in influenza virus infection is the binding of hemagglutinin to sialic acid-containing glycans present on the cell surface. Over 50 different sialic acid modifications are known, of which N-acetylneuraminic acid (Neu5Ac) and N ...
Cindy M. Spruit +5 more
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N-Glycolylneuraminic Acid as a Receptor for Influenza A Viruses [PDF]
Cell Reports, 2019 Summary: A species barrier for the influenza A virus is the differential expression of sialic acid, which can either be α2,3-linked for avians or α2,6-linked for human viruses.
Frederik Broszeit +19 more
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Aberrant N-glycolylneuraminic acid in breast MCF-7 cancer cells and cancer stem cells [PDF]
Frontiers in Molecular Biosciences, 2022 N-Glycolylneuraminic acid (Neu5Gc) is not normally detected in humans because humans lack the hydroxylase enzyme that converts cytidine-5′-monophosphate-N-acetylneuraminic acid (CMP-Neu5Ac) to CMP-Neu5Gc; thus, any Neu5Gc appearing in the human body is ...
Wenqian Yang +4 more
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Lessening of porcine epidemic diarrhoea virus susceptibility in piglets after editing of the CMP-N-glycolylneuraminic acid hydroxylase gene with CRISPR/Cas9 to nullify N-glycolylneuraminic acid expression. [PDF]
PLoS ONE, 2019 The porcine epidemic diarrhoea virus (PEDV) devastates the health of piglets but may not infect piglets whose CMP-N-glycolylneuraminic acid hydroxylase (CMAH) gene is mutated (knockouts, KO) by using CRISPR/Cas9 gene editing techniques.
Ching-Fu Tu +11 more
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Heterophile carbohydrate antigen N‐glycolylneuraminic acid as a potential biomarker in patients with hepatocellular carcinoma [PDF]
Cancer Reports, 2023 Background and Objectives Hepatocellular carcinoma (HCC) has a high recurrence rate even after radical hepatectomy. More optimal biomarkers may help improve recurrence and prognosis.
Shuji Akimoto +6 more
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A Novel Variant in CMAH Is Associated with Blood Type AB in Ragdoll Cats. [PDF]
PLoS ONE, 2016 The enzyme cytidine monophospho-N-acetylneuraminic acid hydroxylase is associated with the production of sialic acids on cat red blood cells. The cat has one major blood group with three serotypes; the most common blood type A being dominant to type B. A
Barbara Gandolfi +9 more
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N-glycolylneuraminic acid serum biomarker levels are elevated in breast cancer patients at all stages of disease [PDF]
BMC Cancer, 2022 Background Normal human tissues do not express glycans terminating with the sialic acid N-glycolylneuraminic acid (Neu5Gc), yet Neu5Gc-containing glycans have been consistently found in human tumor tissues, cells and secretions and have been proposed as ...
Lucy K. Shewell +13 more
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