Results 131 to 140 of about 4,267 (193)

Investigation of Prokaryotic Non-coding RNS and Their Modifications [PDF]

Non-coding RNAs (ncRNA) are transcripts produced by the cell that are not translated into proteins yet play a fundamental role in maintaining proper regulation and function of cellular activities. The term encompasses a myriad of different types of RNAs,
Foo, Marcus Chun Hoe
core   +1 more source

Emerging roles of RNA methylation modifications in environmental metalloid or metal pollutants toxicity

Ecotoxicology and Environmental Safety
The common environmental metalloid or metal pollutants such as arsenic, cadmium, chromium, lead, aluminum, cobalt and manganese have increasingly significant impacts on public health.
Rongxian Li, Yuan Zhao, Jiao Dai, Nan Zhang, Jiamin Yuan, De Liu, Zuoshun He, Jie Yang, Shiyan Gu   +8 more
doaj   +1 more source

N¹-Methyladenosine modification of mRNA regulates neuronal gene expression and oxygen glucose deprivation/reoxygenation induction. [PDF]

Cell Death Discov, 2023
Qi Z, Zhang C, Jian H, Hou M, Lou Y, Kang Y, Wang W, Lv Y, Shang S, Wang C, Li X, Feng S, Zhou H.   +12 more
europepmc   +1 more source

Unravelling the impact of RNA methylation genetic and epigenetic machinery in the treatment of cardiomyopathy

Pharmacological Research
Cardiomyopathy (CM) represents a heterogeneous group of diseases primarily affecting cardiac structure and function, with genetic and epigenetic dysregulation playing a pivotal role in its pathogenesis.
Li Liu, Linxing Yu, Yubo Wang, Liufang Zhou, Yan Liu, Xingshou Pan, Jianjun Huang   +6 more
doaj   +1 more source

RNA m1A methyltransferase TRMT61A promotes colorectal tumorigenesis by enhancing ONECUT2 mRNA stability and is a potential therapeutic target

Cancer Communications
Background The role of N1‐methyladenosine (m1A) in cancer is poorly understood. Here we explored the function of RNA methyltransferase TRNA methyltransferase 61A (TRMT61A) in colorectal cancer (CRC) and its potential as a therapeutic target.
Xiaoting Zhang, Na Qin, Fenfen Ji, Hao Su, Haiyun Shang, Hongyan Chen, Dan Huang, Qing Li, Jing Ren, Weixin Liu, Yifei Wang, Wei Kang, Jiabin Wu, Chi‐Chun Wong, Zongwei Cai, Matthew Tak Vai Chan, William Ka Kei Wu, Jun Yu, Huarong Chen   +18 more
doaj   +1 more source

N¹-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism. [PDF]

Nat Commun, 2021
Wang Y, Wang J, Li X, Xiong X, Wang J, Zhou Z, Zhu X, Gu Y, Dominissini D, He L, Tian Y, Yi C, Fan Z.   +12 more
europepmc   +1 more source

ALKBH3‐Mediated M1A Demethylation of METTL3 Endows Pathological Fibrosis:Interplay Between M1A and M6A RNA Methylation

Advanced Science
Epigenetic modifications serve as crucial molecular switches for pathological fibrosis; howbeit the role of m1A in this condition remains enigmatic. Herein, it is found that ALKBH3 exerts a pro‐fibrotic effect in pathological skin fibrosis by reshaping ...
Liying Tu, Shuchen Gu, Ruoqing Xu, En Yang, Xin Huang, Hsin Liang, Shenying Luo, Haizhou Li, Yixuan Zhao, Tao Zan   +9 more
doaj   +1 more source

Effect of N1-methyladenosine in the quantification of RNA

The Journal of Biochemistry
Abstract The reverse transcription (RT) of RNA to cDNA is a key step for the quantification of nucleic acid molecules in numerous basic research and medical diagnosis. Although multiple sources of errors have been considered, little is known about the impact of RNA modifications on the validity of genes of interest for quantitative RT ...
openaire   +2 more sources

A Fluorescent Aptasensor for Sensitive and Selective Determination of Epigenetic Cancer Biomarker N¹-Methyladenosine in Urine Samples. [PDF]

Chemistry
Bağda E, Bağda E, Liu J.
europepmc   +1 more source