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Nanobodies in therapeutic applications.
Current opinion in molecular therapeutics, 2007Over the years, many antibodies have been successfully generated to treat patients with life-threatening diseases, most notably cancer. While the first generation of antibodies, originating from mice, caused severe side effects and were relatively inefficient, technological advances have made it possible to obtain fully human antibodies for therapeutic
Roovers, Rob C. +2 more
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Nanobodies: Natural Single-Domain Antibodies
Annual Review of Biochemistry, 2013Sera of camelids contain both conventional heterotetrameric antibodies and unique functional heavy (H)-chain antibodies (HCAbs). The H chain of these homodimeric antibodies consists of one antigen-binding domain, the VHH, and two constant domains.
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Nanobody exchange chromatography
2021The present invention relates to the field of affinity purification and provides for means and methods applying protein binding agents competing for a target protein for use as capture and elution tool, wherein the elution agent comprises an immunoglobulin single variable domain (ISVD), and is capable of displacing the capturing binding agent.
Steyaert, Jan +6 more
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Nanobody-functionalized polymersomes
Journal of Controlled Release, 2015Tao, Zou +5 more
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2016
The present invention relates to nanobodies specifically directed against VCAM-1 and to the use thereof in medical imaging and in diagnostic, prognostic and treatment methods.
Ghezzi, Catherine +5 more
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The present invention relates to nanobodies specifically directed against VCAM-1 and to the use thereof in medical imaging and in diagnostic, prognostic and treatment methods.
Ghezzi, Catherine +5 more
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