Nanobody mediated inhibition of attachment of F18 fimbriae expressing Escherichia coli [PDF]
, 2014 Post-weaning diarrhea and edema disease caused by F18 fimbriated E. coli are important diseases in newly weaned piglets and lead to severe production losses in farming industry.
Coddens, Annelies +6 more
core +8 more sources
Electrochemical detection of Toxocara canis excretory-secretory antigens in children from rural communities in Esmeraldas Province, Ecuador: association between active infection and high eosinophilia. [PDF]
, 2020 BACKGROUND: The diagnosis of active Toxocara canis infections in humans is challenging. Larval stages of T. canis do not replicate in human tissues and disease may result from infection with a single T. canis larva.
Chico, M +9 more
core +3 more sources
Immunogenicity Risk Profile of Nanobodies [PDF]
Frontiers in Immunology, 2021 Nanobodies (Nbs), the variable domains of camelid heavy chain-only antibodies, are a promising class of therapeutics or in vivo imaging reagents entering the clinic. They possess unique characteristics, including a minimal size, providing fast pharmacokinetics, high-target specificity, and an affinity in the (sub-)nanomolar range in conjunction with an
Chloé Ackaert +17 more
openaire +5 more sources
Single-Domain Antibody-Based TCR-Like CAR-T: A Potential Cancer Therapy
Journal of Immunology Research, 2020 Retargeting the antigen-binding specificity of T cells to intracellular antigens that are degraded and presented on the tumor surface by engineering chimeric antigen receptor (CAR), also named TCR-like antibody CAR-T, remains limited.
Lichen Zhu +15 more
doaj +1 more source
Improved detection of molecular markers of atherosclerotic plaques using sub-millimeter PET imaging [PDF]
, 2020 Since atherosclerotic plaques are small and sparse, their non-invasive detection via PET imaging requires both highly specific radiotracers as well as imaging systems with high sensitivity and resolution.
Bormans, Guy +11 more
core +2 more sources
Design of a humanized anti vascular endothelial growth factor nanobody and evaluation of its in vitro function [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): Nanobodies, the single domain antigen binding fragments of heavy chain-only antibodies occurring naturally in camelid sera, are the smallest intact antigen binding entities.
Fatemeh Kazemi-Lomedasht +3 more
doaj +1 more source
Description of a nanobody-based competitive immunoassay to detect tsetse fly exposure [PDF]
, 2015 Background : Tsetse flies are the main vectors of human and animal African trypanosomes. The Tsal proteins in tsetse fly saliva were previously identified as suitable biomarkers of bite exposure.
Caljon, Guy +3 more
core +11 more sources
Nanobody-Targeted Photodynamic Therapy: Nanobody Production and Purification
, 2022 Nanobodies have recently been introduced to the field of photodynamic therapy (PDT) as a very promising strategy to target photosensitizers selectively to cancer cells. Nanobodies are known for their characteristic small size (15 kDa), high specificity, and high binding affinities.
Mashayekhi, Vida +4 more
openaire +4 more sources
Tumour inhibitory activity on pancreatic cancer by bispecific nanobody targeting PD-L1 and CXCR4
BMC Cancer, 2022 Background: Antibodies and derivative drugs targeting immune checkpoints have been approved for the treatment of several malignancies, but there are fewer responses in patients with pancreatic cancer.
Shuai Hao +10 more
doaj +1 more source
Frontiers in Oncology, 2021 Breast cancer is the most common malignant cancer in women worldwide, especially in developing countries. Herceptin is a monoclonal antibody with an antitumor effect in HER2-positive breast cancer. However, the large molecular weight of Herceptin limited
Yan Yan +9 more
doaj +1 more source