Results 21 to 30 of about 19,829 (313)
Development and Characterization of Nanobody-Derived CD47 Theranostic Pairs in Solid Tumors
Research, 2023 Overexpression of CD47 is frequently observed in various types of human malignancies, inhibiting myeloid-mediated elimination of tumor cells and affecting the prognosis of cancer patients.
You Zhang +10 more
semanticscholar +1 more source
Fabrication and Functionalisation of Nanocarbon‐Based Field‐Effect Transistor Biosensors
ChemBioChem, Volume 23, Issue 23, December 5, 2022., 2022 Next‐generation diagnostics: Nanocarbon‐based field effect transistors (NC‐FETs) use incoming target analytes to impart a gating effect on conductance. Here, we review the operational mechanisms behind NC‐FETs, the fabrication and functionalisation of NC‐FETs with receptor biomolecules and downstream biosensing applications.
Chang‐Seuk Lee +4 more
wiley +1 more source
Nanobody-based CAR-T cells for cancer immunotherapy
Biomarker Research, 2022 Chimeric antigen receptor T-cell (CAR-T) therapy is the result of combining genetic engineering-based cancer immunotherapy with adoptive cell therapy (ACT). CAR-T therapy has been successful in treating various types of hematological cancers.
Pouya Safarzadeh Kozani +6 more
semanticscholar +1 more source
The Therapeutic Potential of Nanobodies [PDF]
BioDrugs, 2019 Today, bio-medical efforts are entering the subcellular level, which is witnessed with the fast-developing fields of nanomedicine, nanodiagnostics and nanotherapy in conjunction with the implementation of nanoparticles for disease prevention, diagnosis, therapy and follow-up.
Ivana Jovčevska, Serge Muyldermans
openaire +3 more sources
Single-Domain Antibody-Based TCR-Like CAR-T: A Potential Cancer Therapy
Journal of Immunology Research, 2020 Retargeting the antigen-binding specificity of T cells to intracellular antigens that are degraded and presented on the tumor surface by engineering chimeric antigen receptor (CAR), also named TCR-like antibody CAR-T, remains limited.
Lichen Zhu +15 more
doaj +1 more source
Camel nanobody-based B7-H3 CAR-T cells show high efficacy against large solid tumours
Nature Communications, 2023 Rational design of chimeric antigen receptor T (CAR-T) cells based on the recognition of antigenic epitopes capable of evoking the most potent CAR activation is an important objective in optimizing immune therapy. In solid tumors, the B7-H3 transmembrane
Dan Li +12 more
semanticscholar +1 more source
Nanobodies that Neutralize HIV [PDF]
Vaccines, 2019 Nanobodies or VHH (variable domains of heavy-chain only antibodies) are derived from camelid species such as llamas and camels. Nanobodies isolated and selected through phage display can neutralize a broad range of human immunodeficiency virus type 1 (HIV-1) strains.
Robin A. Weiss, C. Theo Verrips
openaire +3 more sources
Design of a humanized anti vascular endothelial growth factor nanobody and evaluation of its in vitro function [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): Nanobodies, the single domain antigen binding fragments of heavy chain-only antibodies occurring naturally in camelid sera, are the smallest intact antigen binding entities.
Fatemeh Kazemi-Lomedasht +3 more
doaj +1 more source
bioRxiv, 2023 Background The blood brain barrier limits entry of macromolecular diagnostic and therapeutic cargos. Blood brain barrier transcytosis via receptor mediated transport systems, such as the transferrin receptor, can be used to carry macromolecular cargos ...
Thomas J. Esparza +5 more
semanticscholar +1 more source
Tumour inhibitory activity on pancreatic cancer by bispecific nanobody targeting PD-L1 and CXCR4
BMC Cancer, 2022 Background: Antibodies and derivative drugs targeting immune checkpoints have been approved for the treatment of several malignancies, but there are fewer responses in patients with pancreatic cancer.
Shuai Hao +10 more
doaj +1 more source