Exploring the toxic mechanism of excessive intake of naringin on drug-induced liver injury using network toxicology and experiment validation strategy [PDF]
BMC Pharmacology and ToxicologyBackground Excessive intake of citrus fruits may affect liver metabolism and trigger various adverse reactions. Naringin, a natural flavonoid compound, is mainly extracted from the citrus fruits.
Yu Ding +5 more
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Novel Acylated Naringin Enhances Propionate Release and Stimulates the Growth of Flavanone-Metabolizing Bacteria in an In Vitro Batch Fermentation Model [PDF]
LifeThe increasing prevalence of non-communicable diseases (NCDs) is strongly associated with gut microbiota (GM) imbalances and reduced short-chain fatty acid (SCFA) production, primarily driven by poor diet and microbial dysbiosis.
Blanca Elizabeth Ruiz-Álvarez +4 more
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Naringin mitigates experimental autoimmune prostatitis by modulating oxidative stress and the NLRP3 inflammasome via the PPAR-γ/NF-κB pathway [PDF]
Scientific ReportsChronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a debilitating condition characterized by pelvic pain and discomfort, necessitating the exploration of effective therapeutic strategies. This study aimed to elucidate the therapeutic potential
Wang Zhou +6 more
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Foods, 2022 Naringin is the major polyphenol in bitter orange peel with antioxidant property. However, its pH sensitivity, low solubility, and bitter taste limit its application in food. In this study, naringin–sodium alginate–silk fibroin microspheres were prepared
Hongyue Wang +6 more
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Food Chemistry: X, 2022 Naringin is potential functional and therapeutic ingredient, has low bioavailability because of poor aqueous solubility. In this study, an ovalbumin (OVA)-carboxymethyl konjac glucomannan (CKGM) nano-delivery system was developed to enhance the ...
Weimin Tang +7 more
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Investigation of the interaction of naringin palmitate with bovine serum albumin: spectroscopic analysis and molecular docking. [PDF]
PLoS ONE, 2013 BackgroundBovine serum albumin (BSA) contains high affinity binding sites for several endogenous and exogenous compounds and has been used to replace human serum albumin (HSA), as these two compounds share a similar structure.
Xia Zhang +6 more
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Naringin Interferes Doxorubicin-Induced Myocardial Injury by Promoting the Expression of ECHS1
Frontiers in Pharmacology, 2022 Doxorubicin (DOX) leads to myocardial cell damage and irreversible heart failure, which limits the clinical application of DOX. Naringin has biological functions of inhibiting inflammation, oxidative stress and apoptosis.
Zirui Zhao +15 more
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Naringin Alleviates Diabetic Kidney Disease through Inhibiting Oxidative Stress and Inflammatory Reaction. [PDF]
PLoS ONE, 2015 Naringin, a flavanone glycoside extracted from Citrus grandis Osbeck, has a wide range of pharmacological effects. In the present study we aimed at demonstrating the protective effect of naringin against diabetic kidney disease (DKD) and elucidating its ...
Fenqin Chen +6 more
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Frontiers in Pharmacology, 2021 Naringin has been shown to exert protective effects in an animal model of ulcerative colitis, but detailed mechanisms remain unclear. This study aimed to investigate function and signaling mechanisms underlying naringin-induced therapeutic effects on ...
Jianyi Dong +10 more
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Molecules, 2023 The naringin extraction process was optimised using response surface methodology (RSM). A central component design was adopted, which included four parameters: extraction temperature (X1), material–liquid ratio (X2), extraction time (X3), and ultrasonic ...
Xiao-Lei Yu +6 more
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