Results 11 to 20 of about 226,818 (311)
Organ-specific features of natural killer cells. [PDF]
Nature Reviews Immunology, 2011 Natural killer (NK) cells can be swiftly mobilized by danger signals and are among the earliest arrivals at target organs of disease. However, the role of NK cells in mounting inflammatory responses is often complex and sometimes paradoxical.
La Cava, Antonio +3 more
core +3 more sources
Natural killer (NK) cells in bipolar disorders. [PDF]
Neurosci ApplNeuroinflammation and peripheral immune dysregulations, affecting both innate and adaptive immune responses, have repeatedly been demonstrated in bipolar disorder (BD). Given the increased susceptibility to infections, the chronic inflammation and autoimmune processes, abnormalities affecting the natural killer (NK) cells compartment are likely to play
Tamouza R, Leboyer M, Vieillard V.
europepmc +3 more sources
Natural Born Killers: NK Cells in Cancer Therapy [PDF]
Cancers, 2020 Cellular therapy has emerged as an attractive option for the treatment of cancer, and adoptive transfer of chimeric antigen receptor (CAR) expressing T cells has gained FDA approval in hematologic malignancy. However, limited efficacy was observed using CAR-T therapy in solid tumors.
S. Elizabeth Franks +2 more
openaire +2 more sources
'Unlicensed' natural killer cells dominate the response to cytomegalovirus infection. [PDF]
, 2010 Natural killer (NK) cells expressing inhibitory receptors that bind to self major histocompatibility complex (MHC) class I are 'licensed', or rendered functionally more responsive to stimulation, whereas 'unlicensed' NK cells lacking receptors for self ...
Lanier, Lewis L +2 more
core +3 more sources
Stem Cell Reports, 2017 Summary: Current donor cell-dependent strategies can only produce limited âmade-to-orderâ therapeutic natural killer (NK) cells for limited patients.
Jieming Zeng +3 more
doaj +1 more source
Regulation of NKG2D-Dependent NK Cell Functions: The Yin and the Yang of Receptor Endocytosis. [PDF]
, 2017 Natural-killer receptor group 2, member D (NKG2D) is a well characterized natural killer (NK) cell activating receptor that recognizes several ligands poorly expressed on healthy cells but up-regulated upon stressing stimuli in the context of cancer or ...
Molfetta, R +3 more
core +2 more sources
Natural killer cells in placentation and cancer: Implications for hypertension during pregnancy [PDF]
, 2017 Hypertension during pregnancy is the most common medical condition encountered during gestation. Despite this, knowledge of the mechanisms that underlie the disease and the development of new therapies are limited.
Cornelius, Denise C. +3 more
core +1 more source
Role of inositol phospholipid signaling in natural killer cell biology
Frontiers in Immunology, 2013 Natural Killer (NK) cells are important in the host defense against malignancy and infection. At a cellular level NK cells are activated when signals from activating receptors exceed signaling from inhibitory receptors.
Matthew eGumbleton +3 more
doaj +1 more source
Tumor-associated and immunochemotherapy-dependent long-term alterations of the peripheral blood NK cell compartment in DLBCL patients [PDF]
, 2015 Natural Killer (NK) cells are a key component of tumor immunosurveillance and thus play an important role in rituximab-dependent killing of lymphoma cells via an antibody-dependent cellular cytotoxicity (ADCC) mechanism.
Battella, Simone +13 more
core +1 more source
Affinity Maturation Is Impaired by Natural Killer Cell Suppression of Germinal Centers
Cell Reports, 2018 Summary: Somatic hypermutation of immunoglobulin sequences in germinal center (GC) reactions must be optimized to elicit high-affinity, protective antibodies after vaccination.
Carolyn E. Rydyznski +6 more
doaj +1 more source