Results 31 to 40 of about 1,001 (177)

Integrating Simulation Modeling and Network Data Envelopment Analysis for Healthcare Supply Chain Management [PDF]

پژوهش در مدیریت تولید و عملیات
Purpose: Nowadays, in healthcare management, performance evaluation of hospital emergency departments (EDs) has received increased attention because of epidemic diseases.
Masoomeh Zeinalnezhad, Somayeh Alavi, Nassibeh Janatyan, Parviz Ghafariasl   +3 more
doaj   +1 more source

Development and Validation of a Method for the Semi-Quantitative Determination of N-Nitrosamines in Active Pharmaceutical Ingredient Enalapril Maleate by Means of Derivatisation and Detection by HPLC with Fluorimetric Detector

Applied Sciences, 2021
A novel HPLC method with fluorimetric detection was developed for the determination of potentially carcinogenic N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA) in active pharmaceutical ingredient enalapril maleate.
Dariusz Boczar, Elżbieta Wyszomirska, Beata Zabrzewska, Anna Chyła, Katarzyna Michalska   +4 more
doaj   +1 more source

Antioxidant and Hepatoprotective Effect of Cajanus cajan in N-Nitrosodiethylamine-Induced Liver Damage

Scientia Pharmaceutica, 2019
N-Nitrosodiethylamine (NDEA) is a nitrosamine derivative with carcinogenic and mutagenic properties which can be found in tobacco smoke, meat and various food products.
Emeka Eze Joshua Iweala, Winifred Osa Evbakhavbokun, Emmanuel Ndubisi Maduagwu   +2 more
doaj   +1 more source

INHIBITION OF EXPERIMENTAL CARCINOGENESIS BY THE BIOACTIVE NATURAL PRODUCT BIOBRAN. [PDF]

Journal of Plant Protection and Pathology, 2016
To investigate  the  protective effects of  biobran against N-nitrosodiethyamine (NDEA) and carbon tetrachloride CCl4-induced hepatocarcinogenesis in rats.
Reem Othman, Doaa Ali, Nariman Badr El-Din   +2 more
doaj   +1 more source

Environmental concentrations of N-nitrosodiethylamine (NDEA) disturb the Ca2 + and K+ homeostasis in the gills and epidermis of mosquitofish (Gambusia affinis)

Ecotoxicology and Environmental Safety
N-nitrosodiethylamine (NDEA), a nitrogenous disinfection by-product, is notorious for its ubiquitous presence in the environment and its carcinogenic properties. However, its impact on ion homeostasis in aquatic organisms remains underexplored.
Xiaoyu Yan, Wenwen Chen, Xiaohong Song, Yun Ma, Haiqin Wang, Tao Yang, Yanpeng Liang, Honghu Zeng   +7 more
doaj   +1 more source

Unlocking the Future of Insurance: The Power of Open Data, Digital Transformation, and Human Talent

Human Resource Development Quarterly, EarlyView.
ABSTRACT Despite rapid technological advancement in insurance, there remains a critical gap in understanding how open data initiatives affect employee digital competencies and organizational transformation. This research investigates this relationship through a systematic review of 51 scholarly articles published between 2018 and 2024, using structured
Narongsak Sukma, Siriporn Yamnill
wiley   +1 more source

Protective effects of epicatechin on the oxidation and N-nitrosamine formation of oxidatively stressed myofibrillar protein

International Journal of Food Properties, 2019
The present study investigated the protective effects of the polyphenol epicatechin on the protein structural changes, gel properties and N-nitrosodiethylamine (NDEA) formation of oxidatively stressed myofibrillar protein (MP).
Ling Li, Hui Ji
doaj   +1 more source

Risk Assessment Models for Heated Tobacco Products

Risk Analysis, Volume 46, Issue 8, August 2026.
ABSTRACT Heated tobacco products (HTPs) are marketed as alternatives to conventional cigarettes with a potential reduced risk profile. Yet, their actual impact on cancer and noncancer disease risk remains uncertain and requires rigorous quantitative assessment.
Lucia Maddalena, Beril Yildiz, Francesca Del Vecchio Blanco, Mario Rosario Guarracino   +3 more
wiley   +1 more source

Regulation of Endoplasmic Reticulum Stress Suppresses Early Pro‐Tumorigenic Events During N‐Nitrosodiethylamine‐Induced Hepatocarcinogenesis

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 7, July 2026.
Schematic illustration of the effect of BIX in attenuating the initiation stage of hepatocarcinogenesis. BIX pre‐treatment mitigated N‐nitrosodiethylamine‐induced ER stress, DNA damage, and downstream pro‐tumorigenic events during the initiation phase. It preserved DNA repair capacity, reduced inflammation and cellular proliferation, thereby inhibiting
Maya P. Shetty, Smita Hegde, Sanjay Bharati   +2 more
wiley   +1 more source

Investigation on the mechanistic approach of trigonelline action in attenuating nitrosodiethylamine instigated rodent experimental liver injury

Journal of Basic and Applied Zoology
Background Researches document a continued increase in liver diseases world over. Factors like obesity, alcohol, synthetic drugs, parasites/viruses, and nitrosamines are reported to contribute majority of liver diseases. It has been argued that oxidative
Mohd Danish, Riaz Ahmad
doaj   +1 more source