Results 51 to 60 of about 1,001 (177)

Optimizing clarification processes in biopharmaceutical manufacturing through quality by design: Strategies, implications, and future prospects

Biotechnology Progress, Volume 41, Issue 6, November/December 2025.
Abstract Biopharmaceutical manufacturing processes in which the product of interest is extracellularly expressed typically employ a clarification step following cell culture or fermentation. During clarification, crude cell culture fluid or fermentation broth is processed to remove insoluble solids, cells, debris, and other particulates, with the ...
Kyeong‐won Yeop, Hyun‐ju Nam, Chang‐jae Shim, So‐mi Yang, Hyo‐won Kim, Cheon Ik Park, Subhasis Banerjee, Yanglin Mok   +7 more
wiley   +1 more source

Combined Maternal and Paternal Low‐Dose N‐Nitrosodimethylamine Exposure: Maternal Alterations and Developmental Toxicity in Rats

Birth Defects Research, Volume 117, Issue 10, October 2025.
ABSTRACT Background N‐Nitrosodimethylamine (NDMA) is an organic xenobiotic compound and a well‐established mutagen and carcinogen. Its potential to cause reproductive and developmental toxicity at low, relevant doses is unclear. This study evaluated the effects of combined maternal and paternal NDMA exposure, both preconceptionally and during gestation,
Julia Tavares Alves, Luara Magalhães, Julia Vitoria Francisco de Aquino, Otávio Galassi Vitale, Giovanna Ferrari Rosalem, Giovanna Kugel Marraschi, Reggina Lorena Mellado Castro, Sara Tawany Caetano dos Santos, Livia Trippe Nagaoka, Julia Stein, Hamilton Hisano, Bárbara Campos Jorge, Arielle Cristina Arena   +12 more
wiley   +1 more source

A systematic review of network data envelopment analysis with an uncertainty approach [PDF]

Muṭāli̒āt-i Mudīriyyat-i Ṣan̒atī
Purpose: Over the past decade, the development of Network Data Envelopment Analysis (NDEA) models has enabled researchers to capture the internal structures and interrelationships among sub-units of decision-making units (DMUs).
Hossein Sayyadi Tooranloo, Mohammad Zarei Mahmoudabadi, Reza Norouzi Avargani   +2 more
doaj   +1 more source

Quantitative Investigation of Nitrosamine Drug Substance‐Related Impurities (NDSRIs) Under Artificial Gastric Conditions by Liquid Chromatography–Tandem Mass Spectrometry and Structure–Activity Relationship Analysis

Drug Testing and Analysis, Volume 17, Issue 9, Page 1772-1784, September 2025.
The study provides information about the impact of physiological gastric conditions on the unbeneficial occurrence of nitrosamine drug substance–related impurities (NDSRIs). Both main factors for nitrosation in the form of acidic conditions and the presence of nitrite were adequately chosen for triggering the conversion of drug compounds into NDSRIs ...
Matthias Vogel, Sylvia E. Escher, Emanuel Weiler, Anke Londenberg, Uwe Deppenmeier, Rhys Whomsley   +5 more
wiley   +1 more source

Evaluating the Role of Autochthonous Lactic Acid Bacteria and Ripening Conditions on Nitrosamine Inhibition in Sucuk Over Storage Time

Food Science &Nutrition, Volume 13, Issue 9, September 2025.
The autochthonous lactic acid bacteria inhibited NDMA. Differences were noted among strains in terms of acid formation. At the end of ripening, slow ripening yields higher residual nitrite than rapid ripening. ABSTRACT The study determined the effects of lactic acid bacteria (LAB) (LS: Latilactobacillus sakei S15, LP: Lactiplantibacillus plantarum S91,
Selen Sallan, Zeynep Feyza Yılmaz Oral, Yağmur Akyol, Güzin Kaban, Mükerrem Kaya   +4 more
wiley   +1 more source

Eugenol: An Insight Into the Anticancer Perspective and Pharmacological Aspects

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
Eugenol (Eug), a volatile phenolic bioactive compound with formula of C10H12O2 have been reported with anticancer, antidiabetic, cardio‐ and pulmonary protective role. Moreover, it has the ability to improve gut health and prevent neurodegenerative disorders. According to WHO, the safe dose of Eug is 2.5 mg/kg for consumption.
Ahmad Mujtaba Noman, Muhammad Tauseef Sultan, Aimen Mazhar, Waqas Ahmad Khan, Muhammad Imran, Muzzamal Hussain, Ehab M. Mostafa, Ahmed H. El‐Ghorab, Mohammed M. Ghoneim, Samy Selim, Mohamed A. Abdelgawad, Entessar Al Jbawi, Suliman A. Alsagaby, Waleed Al Abdulmonem   +13 more
wiley   +1 more source

Membran‐Bioreaktor‐Technik kombiniert mit nachgeschalteter Ozonung – Vergleich mit konventionellen Ozonanwendungen Combination of Membrane Bioreactor and Downstream Ozonation – A Comparison to Conventional Ozone Applications

Chemie Ingenieur Technik, Volume 97, Issue 7, Page 677-688, July 2025.
Kommunale Kläranlagen gelten als Haupteintragspfad organischer Mikroschadstoffe in die aquatische Umwelt. Ein Großteil der Arzneimittelrückstände und Industriechemikalien wird in Kläranlagen nicht oder nur teilweise entfernt. Um einen qualitativ höheren Kläranlagen‐Ablauf zu erzeugen, wird eine Kombination aus hybridem Teilstrom‐Membran‐Bioreaktor mit ...
Maximilian Werner, Jie Ji, Minyi Yin, Holger Lutze, Stefan Panglisch   +4 more
wiley   +1 more source

Performance evaluation of Taiwanese international tourist hotels: evidence from a modified NDEA model with ICA technique

Technological and Economic Development of Economy, 2018
The motivation for this study is to assess the managerial performance in Taiwanese international tourist hotels based on the two-stage NDEA performance mechanism with ICA technique for enhancing the discriminatory power of performance evaluation model ...
Sheng-Hsiung Chiu, Tzu-Yu Lin
doaj   +1 more source

Benchmark Response (BMR) Values for In Vivo Mutagenicity Endpoints

Environmental and Molecular Mutagenesis, Volume 66, Issue 4, Page 172-184, April 2025.
ABSTRACT The benchmark dose (BMD) approach constitutes the most effective and pragmatic strategy for the derivation of a point of departure (PoD) for comparative potency analysis, risk assessment, and regulatory decision‐making. There is considerable controversy regarding the most appropriate benchmark response (BMR) for genotoxicity endpoints.
Paul A. White, Guangchao Chen, Nikolai Chepelev, Madison A. Bell, Lauren R. Gallant, George E. Johnson, Andreas Zeller, Marc A. Beal, Alexandra S. Long   +8 more
wiley   +1 more source

Evaluation of the effect of exposure to N-nitrosodiethylamine on rat lung and intestine and the protective effect of tyrosol: A Biochemical and Histopathological study [PDF]

Journal of Mazandaran University of Medical Sciences
Background and purpose: N-nitrosodiethylamine (NDEA) is a carcinogenic substance found in various foods. This toxic compound induces oxidative stress, resulting in damage to the structure of several internal organs, particularly the gastrointestinal and ...
Elahe Maleki, Mehryar Zargari, Mansooreh Mirzaei, Abbas Ali Karimpour Malakshah, Fereshteh Talebpour Amiri   +4 more
doaj