Results 41 to 50 of about 1,001 (177)

A Robust and Universal LC–MS/MS Method for Determination of N‐Nitrosodimethylamine in Pharmaceuticals Using a C30 Column

Journal of Separation Science, Volume 49, Issue 6, June 2026.
ABSTRACT Since the 2018 valsartan recall, the genotoxic impurity N‐nitrosodimethylamine (NDMA) has been frequently detected in various pharmaceuticals. Matrix variability often complicates routine testing, requiring customized analyses. We developed a universal LC–MS/MS method enabling consistent NDMA detection across diverse pharmaceuticals ...
Byungchan An, Unyong Kim, Sumin Seo, Jiyu Kim, Chohee Jeong, Woojin Jeong, Eunjin Ko, Juhyeon Kim, Hyun‐Deok Cho, Sang Beom Han   +9 more
wiley   +1 more source

Inactivation Strategies of Clostridium perfringens in Foods: Current Challenges and Emerging Interventions

Food Frontiers, Volume 7, Issue 3, May 2026.
Clostridium perfringens forms heat‐resistant spores that complicate food safety. Physical methods (thermal processing, HPP, vacuum cooling, ozone treatments) and chemical interventions (natural antimicrobials, phosphates, nitrate/nitrite, organic acids) reduce vegetative cells and spores, though spore resistance remains a major challenge in food and ...
Deepak Subedi, Bharath Mallavarapu, Pranita Patil, Sujitha Bhumanapalli, Sandesh Chapagain, Kham Bahadur Khatri, Milan Kandel, Amit Kumar Singh   +7 more
wiley   +1 more source

Potential anti-hepatocellular carcinoma properties and mechanisms of action of clerodane diterpenes isolated from Polyalthia longifolia seeds

Scientific Reports, 2022
Diterpenes are secondary metabolites that have attracted much attention due to their potential biological activities including anti-cancer potential. The aim of the current study is to assess the anticancer potential of the six known clerodane diterpenes
Vinay Bharadwaj Tatipamula, Chandi Vishala Thonangi, Tikam Chand Dakal, Girija Sastry Vedula, Bhanupriya Dhabhai, Haritha Polimati, Annapurna Akula, Ha Thi Nguyen   +7 more
doaj   +1 more source

CASPASE-3 and FAS-L expression and their roles as signal transduction in hepatocellular carcinoma [PDF]

Bulletin of the National Nutrition Institute of the Arab Republic of Egypt, 2018
Hepatocellular carcinoma (HCC) is a common malignant affecting approximately-one million of people around the world every year. This study aimed to early recognition of the carcinogenic effect of N-nitrosodiethlyamine (NDEA) on hepatocytes and expression
Soha Hamdy, Saad El-Gendy, Sahar Atrees
doaj   +1 more source

Ameliorative Effect of Beetroot Against Folic Acid Deficiency: A Review

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
Beets, as well as folic acid supplements, provide a possible nutritional intervention for nutritional insufficiency, and this is especially true in functional foods. Offering a holistic explanation of beetroot's medicinal properties, this paper explores the means by which its bioactive constituents can counteract the adverse effects of folic acid ...
Amara Rasheed, Farhan Saeed, Ali Ikram, Muhammad Tayyab Arshad, Sammra Maqsood, Feroza Naveed, Mariam Islam, Emmanuel Laryea   +7 more
wiley   +1 more source

‘Attitude Problems’: Racializing Hierarchies of Affect in Post‐Brown U.S. Science Education

Science Education, Volume 110, Issue 1, Page 123-139, January 2026.
ABSTRACT Attending to the affect of minoritized students now appears crucial to promoting just and dignity‐affirming science education. Yet, elevating affect as an objective of science learning has a history that predates equity reforms. This study explores the politics of scientific uptakes of affect that have long served to mark hierarchical ...
Kathryn L. Kirchgasler
wiley   +1 more source

Mitochondria-targeted antioxidant, mitoQ protects hepatic tissue from N-nitrosodiethylamine-induced damage by modulating mitochondrial function and redox status

Advances in Redox Research
Background: Targeting mitochondrial oxidative stress can be a promising strategy for the prevention of hepatocellular carcinoma (HCC). In the current study, we investigated the modulatory effect of mitochondria-targeted antioxidant, mitoQ against N ...
H.S. Qsee, Sachin Shetty, Shounak De, Sanjay Bharati   +3 more
doaj   +1 more source

Nitrosamine exposure exacerbates high fat diet-mediated type 2 diabetes mellitus, non-alcoholic steatohepatitis, and neurodegeneration with cognitive impairment

Molecular Neurodegeneration, 2009
Background The current epidemics of type 2 diabetes mellitus (T2DM), non-alcoholic steatohepatitis (NASH), and Alzheimer's disease (AD) all represent insulin-resistance diseases.
de la Monte Suzanne M, Tong Ming, Lawton Margot, Longato Lisa   +3 more
doaj   +1 more source

Development and Evolution of Slacks‐Based Measure Models in Data Envelopment Analysis: A Comprehensive Review of the Literature

Journal of Economic Surveys, Volume 39, Issue 5, Page 2106-2133, December 2025.
ABSTRACT This paper provides a comprehensive review of slacks‐based measure (SBM) models within the nonparametric data envelopment analysis (DEA) framework. The review reveals that the development and modifications of SBM models have progressed in multiple directions.
Ali Emrouznejad, Łukasz Brzezicki, Chxiao Lu   +2 more
wiley   +1 more source

Early limited nitrosamine exposures exacerbate high fat diet-mediated type 2 diabetes and neurodegeneration

BMC Endocrine Disorders, 2010
Background Type 2 diabetes mellitus (T2DM) and several types of neurodegeneration, including Alzheimer's, are linked to insulin-resistance, and chronic high dietary fat intake causes T2DM with mild neurodegeneration.
Longato Lisa, Tong Ming, de la Monte Suzanne M   +2 more
doaj   +1 more source