Results 1 to 10 of about 63,427 (187)

Genomic characterization of an NDM-9-producing Acinetobacter baumannii clinical isolate and role of Glu152Lys substitution in the enhanced cefiderocol hydrolysis of NDM-9

Frontiers in Microbiology, 2023
Here, we characterized the first French NDM-9-producing Acinetobacter baumannii isolate. A. baumannii 13A297, which belonged to the STPas25 (international clone IC7), was highly resistant to β-lactams including cefiderocol (MIC >32 mg/L). Whole genome
Susie Gaillot, Saoussen Oueslati, Jean-Baptiste Vuillemenot, Jean-Baptiste Vuillemenot, Maxime Bour, Bogdan I. Iorga, Pauline Triponney, Patrick Plésiat, Patrick Plésiat, Rémy A. Bonnin, Rémy A. Bonnin, Thierry Naas, Thierry Naas, Katy Jeannot, Katy Jeannot, Anaïs Potron, Anaïs Potron   +16 more
doaj   +2 more sources

Clinical and molecular characterization of NDM-9 and NDM-13 producing multidrug-resistant Escherichia coli strains in China [PDF]

BMC Microbiology
Objectives The continuous evolution of NDM variants, some of which exhibit enhanced hydrolytic activity, poses a serious public health threat and necessitates ongoing surveillance.
Jia Tao, Gang Li, Zhichen Zhu, Jie Zhu, Wen Wang, Hui Fu, Hua Yv, Bin Shan, Liru Wang, Yiwei Tang, Liang Chen, Hong Du, Wei Jia   +12 more
doaj   +2 more sources

An NDM-Producing Escherichia coli Clinical Isolate Exhibiting Resistance to Cefiderocol and the Combination of Ceftazidime-Avibactam and Aztreonam: Another Step Toward Pan-β-Lactam Resistance

Open Forum Infectious Diseases, 2023
Background Cefiderocol and ceftazidime-avibactam plus aztreonam (CZA-ATM) are preferred treatment regimens for New Delhi metallo-β-lactamase (NDM)-producing infections.
P. Simner, Y. Bergman, Rick Conzemius, E. Jacobs, Tsigereda Tekle, S. Beisken, P. Tamma   +6 more
semanticscholar   +1 more source

In vitro activity of cefepime/zidebactam and cefepime/taniborbactam against aztreonam/avibactam-resistant NDM-like-producing Escherichia coli clinical isolates

Journal of Antimicrobial Chemotherapy, 2023
Background Aztreonam/avibactam is one of the last therapeutic options for treating infections caused by NDM-like-producing Enterobacterales. However, PBP3-modified and NDM-producing Escherichia coli strains that co-produce CMY-42 have been shown to be ...
C. Terrier, P. Nordmann, Mustafa Sadek, L. Poirel   +3 more
semanticscholar   +1 more source

A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation

Scientific Reports, 2021
Inhibition of the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome has recently emerged as a promising therapeutic target for several inflammatory diseases.
Sohaib Nizami, Val Millar, Kanisa Arunasalam, Tryfon Zarganes-Tzitzikas, David Brough, Gary Tresadern, Paul E. Brennan, John B. Davis, Daniel Ebner, Elena Di Daniel   +9 more
doaj   +1 more source

Rapid cross-border emergence of NDM-5-producing Escherichia coli in the European Union/European Economic Area, 2012 to June 2022

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2023
Whole genome sequencing data of 874 Escherichia coli isolates carrying bla NDM-5 from 13 European Union/European Economic Area countries between 2012 and June 2022 showed the predominance of sequence types ST167, ST405, ST410, ST361 and ST648, and an ...
Marius Linkevicius, R. Bonnin, E. Alm, Olov Svartström, P. Apfalter, R. Hartl, H. Hasman, Louise Roer, Kati Räisänen, L. Dortet, Niels Pfennigwerth, Jörg B Hans, Á. Tóth, Lilla Buzgó, M. Cormican, N. Delappe, M. Monaco, M. Giufrè, A. Hendrickx, Ørjan Samuelsen, A. K. Pöntinen, M. Caniça, V. Manageiro, J. Oteo-Iglesias, M. Pérez-Vázquez, Karin Westmo, B. Mäkitalo, D. Palm, D. Monnet, A. Kohlenberg   +29 more
semanticscholar   +1 more source

Antibiotic-resistance genes in E. coli strains in GCC countries: A meta-analysis

Saudi Journal of Medicine and Medical Sciences, 2022
Background: Antimicrobial resistance (AMR) in Escherichia coli is an alarming issue worldwide, including in the Gulf Cooperation Council (GCC) countries, yet the prevailing gene patterns have not recently been reviewed.
Khalid Mubarak Bindayna, Ronni Mol Joji, Hicham Ezzat, Haitham Ali Jahrami   +3 more
doaj   +1 more source

First detection in Spain of NDM-1-producing Pseudomonas aeruginosa in two patients transferred from Ukraine to a university hospital.

Journal of Global Antimicrobial Resistance, 2023
OBJECTIVES Carbapenemase-mediated carbapenem resistance in Pseudomonas aeruginosa is a relevant health problem. We detected for the first time in Spain two clinical NDM-producing P.
M. Hernández-García, Margarita Cabello, M. Ponce-Alonso, Pedro M Herrador-Gómez, F. Gioia, Javier Cobo, R. Cantón, P. Ruiz-Garbajosa   +7 more
semanticscholar   +1 more source

Genotypic Distribution and Antimicrobial Susceptibilities of Carbapenemase-Producing Enterobacteriaceae Isolated in Tertiary Care Hospital in South India

Journal of Pure and Applied Microbiology, 2022
Antimicrobial resistance has emerged as a major danger to contemporary medicine around the world. Carbapenems are the highest class of B-lactam drugs which are considered as the most effective and safest antibiotics available.
S. Abhishek, Shweta Sagar Naik, K.V. Leela, D. Maheswary   +3 more
doaj   +1 more source

Increase in NDM-1 and NDM-1/OXA-48-producing Klebsiella pneumoniae in Germany associated with the war in Ukraine, 2022

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2022
In 2022, German surveillance systems observed rapidly increasing numbers of NDM-1- and NDM-1/OXA-48-producing Klebsiella pneumoniae, which may in part reflect recurring pre-pandemic trends.
M. Sandfort, Jörg B Hans, Martin A. Fischer, F. Reichert, Martina Cremanns, Jessica Eisfeld, Y. Pfeifer, A. Heck, T. Eckmanns, G. Werner, S. Gatermann, S. Haller, Niels Pfennigwerth   +12 more
semanticscholar   +1 more source