Results 101 to 110 of about 82,892 (269)

Exploring the Complexity of Cortical Development Using Single-Cell Transcriptomics

Frontiers in Neuroscience, 2018
The developing neocortex in the mammalian brain is composed of multiple cell types including apical progenitors (AP), basal progenitors (BP), and neurons that populate three different layers, the ventricular zone (VZ), the subventricular zone (SVZ), and ...
Hyobin Jeong, Vijay K. Tiwari
doaj   +1 more source

T. rex cognition was T. rex‐like—A critical outlook on diverging views of the neurocognitive evolution in dinosaurs

The Anatomical Record, EarlyView.
Abstract A recent debate has emerged between Caspar et al. (2024) and Herculano‐Houzel (2023) on inferring extinct dinosaur cognition by estimating brain neuron counts. While thought‐provoking, the discussion largely overlooks the function of cognition, as well as partly neglects the difficulties involved in estimating neuron numbers, which according ...
Thomas Rejsenhus Jensen, Ivo Jacobs, Kristina Kverková, Lona Lalić, Alexandra Polonyiová, Patrik Stehlík, Stephan A. Reber, Mathias Osvath   +7 more
wiley   +1 more source

The Superior Function of the Subplate in Early Neocortical Development

Frontiers in Neuroanatomy, 2018
During early development the structure and function of the cerebral cortex is critically organized by subplate neurons (SPNs), a mostly transient population of glutamatergic and GABAergic neurons located below the cortical plate.
Heiko J. Luhmann, Sergei Kirischuk, Werner Kilb   +2 more
doaj   +1 more source

Endothermy, neuron counts, and other issues: Further remarks on neurocognitive evolution in fossil vertebrates

The Anatomical Record, EarlyView.
Abstract Last year, we challenged the view that large‐bodied theropod dinosaurs such as Tyrannosaurus rex resembled primates in cognition and behavior, a proposition made by Herculano‐Houzel in 2023. More recently, Jensen et al. have criticized our work on this topic, raising methodological and conceptual issues.
Kai R. Caspar, Cristián Gutiérrez‐Ibáñez, Hady George, Thomas R. Holtz Jr., Darren Naish, Grant R. Hurlburt   +5 more
wiley   +1 more source

TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia

CNS Neuroscience &Therapeutics, EarlyView., 2023
Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi, Decheng Ren, Fan Yuan, Zhou Zhang, Daizhan Zhou, Xin Yi, Lei Ji, Keyi Li, Fengping Yang, Xi Wu, Xingwang Li, Yifeng Xu, Yun Liu, Peng Wang, Changqun Cai, Chuanxin Liu, Qian Ma, Lin He, Yi Shi, Guang He   +19 more
wiley   +1 more source

The growth factor EPIREGULIN promotes basal progenitor cell proliferation in the developing neocortex

The EMBO Journal
Neocortex expansion during evolution is linked to higher numbers of neurons, which are thought to result from increased proliferative capacity and neurogenic potential of basal progenitor cells during development.
Paula Cubillos, Nora Ditzer, Annika Kolodziejczyk, Gustav Schwenk, Janine Hoffmann, Theresa M Schütze, Razvan P Derihaci, Cahit Birdir, Johannes EM Köllner, Andreas Petzold, Mihail Sarov, Ulrich Martin, Katherine R Long, Pauline Wimberger, Mareike Albert   +14 more
doaj   +1 more source

The E3 Ubiquitin Ligase UBE3B Regulates Synaptic Development and Cortical Network Activity

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired communication, abnormal social interactions, and restricted, repetitive behaviors. Pathogenic mutations in UBE3B result in neurodevelopmental disease, including intellectual disability, lack of speech, and ASD.
Shayal Vashisth, Aleya Shedd, Ariel Aiken, Solmi Cheon, Josh Bandopadhay, Kiran Kaur, Kimberly M. Huber, Maria H. Chahrour   +7 more
wiley   +1 more source

Overproduction of Upper-Layer Neurons in the Neocortex Leads to Autism-like Features in Mice

Cell Reports, 2014
Summary: The functional integrity of the neocortex depends upon proper numbers of excitatory and inhibitory neurons; however, the consequences of dysregulated neuronal production during the development of the neocortex are unclear.
Wei-Qun Fang, Wei-Wei Chen, Liwen Jiang, Kai Liu, Wing-Ho Yung, Amy K.Y. Fu, Nancy Y. Ip   +6 more
doaj   +1 more source

Empiricism without Magic: Transformational Abstraction in Deep Convolutional Neural Networks [PDF]

, 2018
In artificial intelligence, recent research has demonstrated the remarkable potential of Deep Convolutional Neural Networks (DCNNs), which seem to exceed state-of-the-art performance in new domains weekly, especially on the sorts of very difficult ...
Buckner, Cameron
core   +1 more source

Ictal semiology in lateral temporal epilepsy: A systematic review and meta‐analysis

Epileptic Disorders, EarlyView.
Abstract Objective We performed a systematic review of the ictal semiology of the lateral temporal lobe in focal epilepsy aiming to summarize the state‐of‐the‐art anatomo‐clinical correlations in the field and help guide interpretation of ictal semiology within the framework of pre‐surgical evaluation.
Jakob I. Doerrfuss, Georg Zimmermann, Martin Holtkamp   +2 more
wiley   +1 more source