Afucosylated IgG in idiopathic nephrotic syndrome patients with anti-nephrin autoantibodies correlate with disease activity [PDF]
Journal of Translational AutoimmunityBackground: Idiopathic nephrotic syndrome (INS) is a glomerular disorder characterized by podocyte injury and proteinuria. Emerging evidence suggests that anti-nephrin autoantibodies (Abs) may contribute to disease pathogenesis in a subset of INS ...
Sonia Spinelli +18 more
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Reflective versus predictive value of urinary podocin, nephrin, and their ratio in diabetic kidney disease: a 12-month retrospective cohort study [PDF]
Frontiers in NephrologyIntroductionPodocyte injury plays a central role in the development of diabetic kidney disease (DKD). Urinary podocin, nephrin, and the podocin–nephrin ratio (PNR) have been proposed as early indicators of glomerular injury, but their prognostic value ...
Pringgodigdo Nugroho +8 more
doaj +2 more sources
Reduced nephrin tyrosine phosphorylation impairs podocyte force transmission and accelerates detachment in disease [PDF]
iScienceSummary: Podocytes are specialized kidney cells that form the slit diaphragm (SD), an intercellular filtration barrier against plasma protein loss. The SD is subject to significant mechanical strain which can be amplified in disease, leading to podocyte ...
Casey R. Williamson +9 more
doaj +2 more sources
Activation of Rac-1 and RhoA contributes to podocyte injury in chronic kidney disease [PDF]
, 2013 Rho-family GTPases like RhoA and Rac-1 are potent regulators of cellular signaling that control gene expression, migration and inflammation. Activation of Rho-GTPases has been linked to podocyte dysfunction, a feature of chronic kidney diseases (CKD). We
Amann, Kerstin +13 more
core +19 more sources
Frontiers in Physiology, 2022 Serum and glucocorticoid-inducible kinase 3 (SGK3) is involved in maintaining podocyte function by regulating the protein levels of podocin and CD2-associated protein.
Qing-Qing Dong +7 more
doaj +1 more source
Integrin Ligation Results in Nephrin Tyrosine Phosphorylation In Vitro. [PDF]
PLoS ONE, 2016 Nephrin is expressed at the basolateral aspect of podocytes and is an important signaling protein at the glomerular slit diaphragm. In vitro studies have demonstrated that Nephrin phosphorylation-dependent signaling is able to assemble a protein complex ...
Rakesh Verma +4 more
doaj +1 more source
Rap1 Activity Is Essential for Focal Adhesion and Slit Diaphragm Integrity
Frontiers in Cell and Developmental Biology, 2022 Glomerular podocytes build, with their intercellular junctions, part of the kidney filter. The podocyte cell adhesion protein, nephrin, is essential for developing and maintaining slit diaphragms as functional loss in humans results in heavy proteinuria.
Mee-Ling Maywald +9 more
doaj +1 more source
Establishment of Nephrin Reporter Mice and Use for Chemical Screening. [PDF]
PLoS ONE, 2016 Nephrin is a critical component of glomerular filtration barrier, which is important to maintain glomerular structure and avoid proteinuria. Downregulation of nephrin expression is commonly observed at early stage of glomerular disorders, suggesting that
Junichi Tsuchida +8 more
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Characterization of a novel disease-associated mutation within NPHS1 and its effects on nephrin phosphorylation and signaling. [PDF]
PLoS ONE, 2018 Mutations in the transmembrane protein nephrin (encoded by NPHS1) underlie nearly half of all cases of congenital nephrotic syndrome (CNS), which is caused by aberrations in the blood filtering function of glomerular podocytes.
C James Cooper +5 more
doaj +1 more source
Serum Nephrin Levels in Severe Preeclampsia: A Cross-Sectional Study
Indonesian Journal of Obstetrics and Gynecology, 2021 Objective: To determine differences in serum nephrin levels in severe preeclampsia compared to normal pregnancy and also its correlation with systolic and diastolic blood pressure and proteinuria.
Meice Fitrina +2 more
doaj +1 more source