Results 111 to 120 of about 12,068 (208)

Diabetic Nephropathy: Perspective on Novel Molecular Mechanisms [PDF]

, 2016
Diabetes mellitus (DM) is the major cause of end-stage renal disease (ESRD) globally, and novel treatments are urgently needed. Current therapeutic approaches for diabetic nephropathy (DN) are focussing on blood pressure control with inhibitors of the ...
Coward, RJ, Gnudi, L, Long, DA
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Proteinuria in Primary and Secondary Renal Diseases [PDF]

Journal of Clinical and Diagnostic Research, 2012
Proteinuria is a strong indicator of kidney disease. Various pathological conditions such as diabetes mellitus, cardiovascular disease and hypertension have been shown to provoke secondary kidney problems and significant proteinuria.
Anuradha B. Patil, C.V. B. Prasad, Shivaprasad S.   +2 more
doaj  

Erk5 is a mediator to TGFβ1-induced loss of phenotype and function in human podocytes. [PDF]

, 2014
Background: Podocytes are highly specialized cells integral to the normal functioning kidney, however, in diabetic nephropathy injury occurs leading to a compromised phenotype and podocyte dysfunction which critically produces podocyte loss with ...
Binder, Browne, Chuang, Dalla Vestra, Dessapt, Dorado, Drew, Fioretto, Gagliardini, Goldfarb, Hayashi, Herbach, Herman-Edelstein, Huang, Iwano, Khalil, Kim, Kim, Li, Maeda, Marchetti, Niculescu-Duvaz, Pavenstädt, Phanish, Reeves, Regan, Rocco, Saleem, Schiffer, Shishido, Siegel, Suzaki, Vardouli, Wahab, Winn, Woo, Wu, Zhou, Ziyadeh, Ziyadeh   +39 more
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Role of Antibody Anti-AGE in the Expression of Nephrin and RAGE on Primary Glomerulus Cell Exposed with AGE

Journal of Tropical Life Science, 2017
Upregulation of nephrin expression occurs at the early stage of nephropathy and decrease in the period 6 months on hyperglycaemic condition. Nephrin is associated with the initial stage of the loss of the permeability barrier in diabetic nephropathy ...
Rudy Salam, Diana Lyrawati, Nur Samsu
doaj   +1 more source

Genetic ablation of calcium-independent phospholipase A2γ induces glomerular injury in mice [PDF]

, 2016
Glomerular visceral epithelial cells (podocytes) play a critical role in the maintenance of glomerular permselectivity. Podocyte injury, manifesting as proteinuria, is the cause of many glomerular diseases. We reported previously that calcium-independent
Aoudjit, Lamine, Cybulsky, Andrey V, Elimam, Hanan, Gross, Richard W, Guillemette, Julie, Kaufman, Daniel R, Papillon, Joan, Takano, Tomoko   +7 more
core   +2 more sources

Evaluation of the role of evolutionary conserved polarity mechanisms in the establishment of podocyte architecture

, 2014
Podozyten sind auf Grund ihrer Rolle in der Formierung und dem Erhalt der Schlitzmembran ein essentieller Bestandteil der glomerulären Filtrationsbarriere der Niere. Sowohl Formierung als auch Erhalt der Filtrationsbarriere ist abhängig von der korrekten
Djuric, I. (Ivona)
core  

In mice, proteinuria and renal inflammatory responses to albumin overload are strain-dependent. [PDF]

, 2005
BACKGROUND: The availability of genetically modified mice has increased the need for relevant mouse models of renal disease, but widely used C57BL/6 mice often show resistance to proteinuria.
Goldschmeding, Roel, Hahnel, Brunhilde, Ishola, David A, Joles, Jaap A, Koomans, Hein A, Kriz, Wilhelm, van der Giezen, Dionne M   +6 more
core   +2 more sources

Constitutional Nephrin Deficiency in Conditionally Immortalized Human Podocytes Induced Epithelial-Mesenchymal Transition, Supported by β-Catenin/NF-kappa B Activation: A Consequence of Cell Junction Impairment?

International Journal of Nephrology, 2013
The kidney glomerular podocytes are the cellular target of many chronic nephropathies both determined and acquired genetically. Mutations that affected the expression and/or the function of nephrin, a key component of the slit-diaphragm, are often ...
Gian Marco Ghiggeri, Maddalena Gigante, Armando Di Donato   +2 more
doaj   +1 more source

Molecular Mechanisms of Kidney Injury and Repair in Arterial Hypertension [PDF]

, 2019
The global burden of chronic kidney disease is rising. The etiologies, heterogeneous, and arterial hypertension, are key factors contributing to the development and progression of chronic kidney disease. Arterial hypertension is induced and maintained by
Eckardt, Kai-Uwe, Sievers, Laura Katharina   +1 more
core   +2 more sources

Molecular mechanism of ouabain-induced apoptosis in human podocytes

Linchuang shenzangbing zazhi, 2017
Objective Podocyte apoptosis is involved in lupus nephritis( LN). Endogenous ouabain( EO),one of cardiotonicsteroids( CTS),is markedly up-regulated in chronic kidney disease( CKD) patients and is associated with epithelial-to-mesenchymal transition ...
LOU Mei-yu, LIU Chang-xuan, CHEN Wen-li
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