Results 111 to 120 of about 12,065 (211)

Carboxymethyl lysine induces EMT in podocytes through transcription factor ZEB2:Implications for podocyte depletion and proteinuria in diabetes mellitus [PDF]

, 2015
Advanced glycation end-products (AGEs) are implicated in the pathogenesis of diabetic nephropathy (DN). N-carboxymethyl-lysine (CML) is one of the predominant AGEs that accumulate in all renal compartments of diabetic patients.
Kumar, P Anil, Menon, Ram K, Raghu, G, Reddy, G Bhanuprakash, Saleem, Moin A, Welsh, Gavin I   +5 more
core   +2 more sources

Development of a Novel Diagnostic Test Using Podocyturia as a Biomarker for Detection of Kidney Damage [PDF]

, 2013
Primary glomerular diseases are the most common cause of progressive chronic kidney disease (CKD) in dogs, a common and significant source of illness that often progresses to kidney failure.
Farooqi, Eesha
core   +1 more source

In mice, proteinuria and renal inflammatory responses to albumin overload are strain-dependent. [PDF]

, 2005
BACKGROUND: The availability of genetically modified mice has increased the need for relevant mouse models of renal disease, but widely used C57BL/6 mice often show resistance to proteinuria.
Goldschmeding, Roel, Hahnel, Brunhilde, Ishola, David A, Joles, Jaap A, Koomans, Hein A, Kriz, Wilhelm, van der Giezen, Dionne M   +6 more
core   +2 more sources

Albumin uptake in human podocytes: a possible role for the cubilin-amnionless (CUBAM) complex [PDF]

, 2017
Albumin re-uptake is a receptor-mediated pathway located in renal proximal tubuli. There is increasing evidence of glomerular protein handling by podocytes, but little is known about the mechanism behind this process.
ANGLANI, FRANCA, CEOL, MONICA, DEL PRETE, DORELLA, GIANESELLO, LISA, PRIANTE, GIOVANNA, RADU, CLAUDIA-MARIA, Saleem, Moin A., SIMIONI, PAOLO, TERRIN, LILIANA   +8 more
core   +1 more source

Reduced nephrin tyrosine phosphorylation impairs podocyte force transmission and accelerates detachment in disease

iScience
Summary: Podocytes are specialized kidney cells that form the slit diaphragm (SD), an intercellular filtration barrier against plasma protein loss. The SD is subject to significant mechanical strain which can be amplified in disease, leading to podocyte ...
Casey R. Williamson, Claire E. Martin, J. Dinesh Kumar, Peihua Lu, Laura A. New, Alice Y. Wang, Nils M. Kronenberg, Malte C. Gather, Paul A. Reynolds, Nina Jones   +9 more
doaj   +1 more source

Evaluation of the role of evolutionary conserved polarity mechanisms in the establishment of podocyte architecture

, 2014
Podozyten sind auf Grund ihrer Rolle in der Formierung und dem Erhalt der Schlitzmembran ein essentieller Bestandteil der glomerulären Filtrationsbarriere der Niere. Sowohl Formierung als auch Erhalt der Filtrationsbarriere ist abhängig von der korrekten
Djuric, I. (Ivona)
core  

Diabetic Nephropathy: Perspective on Novel Molecular Mechanisms [PDF]

, 2016
Diabetes mellitus (DM) is the major cause of end-stage renal disease (ESRD) globally, and novel treatments are urgently needed. Current therapeutic approaches for diabetic nephropathy (DN) are focussing on blood pressure control with inhibitors of the ...
Coward, RJ, Gnudi, L, Long, DA
core   +1 more source

Molecular mechanism of ouabain-induced apoptosis in human podocytes

Linchuang shenzangbing zazhi, 2017
Objective Podocyte apoptosis is involved in lupus nephritis( LN). Endogenous ouabain( EO),one of cardiotonicsteroids( CTS),is markedly up-regulated in chronic kidney disease( CKD) patients and is associated with epithelial-to-mesenchymal transition ...
LOU Mei-yu, LIU Chang-xuan, CHEN Wen-li
doaj  

Constitutional Nephrin Deficiency in Conditionally Immortalized Human Podocytes Induced Epithelial-Mesenchymal Transition, Supported by β-Catenin/NF-kappa B Activation: A Consequence of Cell Junction Impairment?

International Journal of Nephrology, 2013
The kidney glomerular podocytes are the cellular target of many chronic nephropathies both determined and acquired genetically. Mutations that affected the expression and/or the function of nephrin, a key component of the slit-diaphragm, are often ...
Gian Marco Ghiggeri, Maddalena Gigante, Armando Di Donato   +2 more
doaj   +1 more source

Proteinuric Kidney Diseases: A Podocyte's Slit Diaphragm and Cytoskeleton Approach

Frontiers in Medicine, 2018
Proteinuric kidney diseases are a group of disorders with diverse pathological mechanisms associated with significant losses of protein in the urine.
Samuel Mon-Wei Yu, Pitchaphon Nissaisorakarn, Irma Husain, Belinda Jim, Belinda Jim   +4 more
doaj   +1 more source