Results 11 to 20 of about 12,068 (208)

A membranous nephropathy variant mimicking minimal change disease. [PDF]

J Pathol Clin Res
Abstract This study characterizes a novel disease pattern of membranous nephropathy (MN) that exhibits overlapping clinicopathological features with minimal change disease (MCD), termed ‘MCD‐like MN’. Patients with histologically confirmed MN showing sparse and segmental subepithelial electron‐dense deposits (EDD) but clinically resembling MCD were ...
Pan C, Xiang S, Jiang M, Li Y, Huang B, Ye T, Du Y, Tang X, Yuan Y.   +8 more
europepmc   +2 more sources

Urinary Nephrin as an Early Biomarker of Hypertensive Nephropathy

Acta Clinica Croatica, 2023
Hypertensive nephropathy (HN) is characterized by kidney damage due to chronic high blood pressure. Podocytes play a crucial role in the pathogenesis of HN, thus, nephrin could be important in the early diagnosis of HN.
Irena Kostovska, Katerina Tosheska Trajkovska, Danica Labudović, Ognen Kostovski, Goce Spasovski   +4 more
doaj   +1 more source

Multivalent nephrin–Nck interactions define a threshold for clustering and tyrosine-dependent nephrin endocytosis [PDF]

Journal of Cell Science, 2020
ABSTRACT Assembly of signaling molecules into micrometer-sized clusters is driven by multivalent protein-protein interactions, such as those found within the nephrin–Nck (Nck1 or Nck2) complex. Phosphorylation on multiple tyrosine residues within the tail of the nephrin transmembrane receptor induces recruitment of the cytoplasmic ...
Claire E. Martin, Laura A. New, Noah J. Phippen, Ava Keyvani Chahi, Alexander E. Mitro, Tomoko Takano, Tony Pawson, Ivan M. Blasutig, Nina Jones   +8 more
openaire   +2 more sources

Nephrin in experimental glomerular disease [PDF]

Kidney International, 2000
The recently identified gene NPHS1 with its mutations causing congenital nephrotic syndrome of the Finnish type (CNF) is highly promising in providing new understanding of pathophysiology of proteinuria. Earlier we cloned a rat NPHS1 homologue, as well as characterized and raised antibodies to the respective protein product nephrin.Changes in the ...
Luimula, Pauliina, Ahola, Heikki, Wang, Shi-Xuan, Solin, Marja-Liisa, Aaltonen, Petri, Tikkanen, Ilkka, Kerjaschki, Dontscho, Holthöfer, Harry   +7 more
openaire   +2 more sources

It's not all about nephrin [PDF]

Kidney International, 2008
Mutations in the NPHS1 gene cause congenital nephrotic syndrome of the Finnish type. The gene product nephrin is a structural component of the glomerular slit diaphragm formed by neighboring podocytes. Nephrin has also been suggested to be involved in signaling processes that are important for podocyte survival and differentiation.
Simons, Matias, Huber, Tobias B.
openaire   +2 more sources

Glycosphingolipid GM3 prevents albuminuria and podocytopathy induced by anti-nephrin antibody

Scientific Reports, 2022
Podocytopathy, which is characterized by injury to podocytes, frequently causes proteinuria or nephrotic syndrome. There is currently a paucity of effective therapeutic drugs to treat proteinuric kidney disease.
Nagako Kawashima, Shokichi Naito, Hisatoshi Hanamatsu, Masaki Nagane, Yasuo Takeuchi, Jun-ichi Furukawa, Norimasa Iwasaki, Tadashi Yamashita, Ken-ichi Nakayama   +8 more
doaj   +1 more source

Urinary Nephrin and Podocalyxin Levels as Predictors of Pre-eclampsia in High-Risk Pregnant Women [PDF]

Folia Medica, 2021
Introduction: Pre-eclampsia (PE) is characterized by new-onset hypertension and proteinuria. Damage of podocyte cells has been reported in pre-eclamptic women, thus podocyte specific proteins such as nephrin and podocalyxin could be useful biomarkers in ...
Irena Kostovska, Katerina Tosheska Trajkovska, Ognen Kostovski, Danica Labudovic   +3 more
doaj   +3 more sources

Inducible Nephrin Transgene Expression in Podocytes Rescues Nephrin-Deficient Mice from Perinatal Death [PDF]

The American Journal of Pathology, 2010
Mutations leading to nephrin loss result in massive proteinuria both in humans and mice. Early perinatal lethality of conventional nephrin knockout mice makes it impossible to determine the role of nephrin protein in the adult kidney and in extra-renal tissues.
Juhila, J., Lassila, M., Roozendaal, R., Lehtonen, E., Messing, M., Langer, B., Kerjaschki, D., Verbeek, J.S., Holthofer, H.   +8 more
openaire   +3 more sources

Podocytic PKC-alpha is regulated in murine and human diabetes and mediates nephrin endocytosis. [PDF]

PLoS ONE, 2010
BACKGROUND: Microalbuminuria is an early lesion during the development of diabetic nephropathy. The loss of high molecular weight proteins in the urine is usually associated with decreased expression of slit diaphragm proteins.
Irini Tossidou, Beina Teng, Jan Menne, Nelli Shushakova, Joon-Keun Park, Jan U Becker, Friedrich Modde, Michael Leitges, Hermann Haller, Mario Schiffer   +9 more
doaj   +1 more source

Characteristics of polyclonal anti-human nephrin antibodies induced by genetic immunization using nephrin cDNA [PDF]

Nephrology Dialysis Transplantation, 2006
Nephrin is an essential protein for maintaining the normal structure of the podocyte foot process and the glomerular filtration barrier. To analyse the mechanism of proteinuria and treatment of nephrotic syndrome, we produced and characterized polyclonal anti-human nephrin antibodies using a newly developed genetic immunization technique.An expression ...
Togo, Aoyama, Kouju, Kamata, Nozomu, Yamanaka, Yasuo, Takeuchi, Masaaki, Higashihara, Seishi, Kato   +5 more
openaire   +2 more sources