Results 61 to 70 of about 12,065 (211)

miR-204-5p Protects Nephrin from Enzymatic Degradation in Cultured Mouse Podocytes Treated with Nephrotoxic Serum

Cells
Nephrin is an essential constituent of the slit diaphragm of the kidney filtering unit. Loss of nephrin expression leads to protein leakage into the urine, one of the hallmarks of kidney damage.
George Haddad, Judith Blaine
doaj   +1 more source

NPHS2 mutation analysis shows genetic heterogeneityof steroid-resistant nephrotic syndrome and lowpost-transplant recurrence [PDF]

, 1926
NPHS2 mutation analysis shows genetic heterogeneity of steroid-resistant nephrotic syndrome and low post-transplant recurrence.BackgroundMutations of NPHS2 are causative in familial autosomal-recessive (AR) and sporadic steroid-resistant nephrotic ...
Weber, Stefanie, Gribouval, Olivier, Esquivel, Ernie L., Morinière, Vincent, Tête, Marie-Josèphe, Legendre, Christophe, Niaudet, Patrick, Antignac, Corinne   +7 more
core   +1 more source

FC015: High Salt Environment Disrupts the Regulatory Effect of Podocin on the Nephrin-Nephrin Distance

Nephrology Dialysis Transplantation, 2022
Abstract BACKGROUND AND AIMS The podocin encoding NPHS2 is the most frequently mutated gene in steroid-resistant nephrotic syndrome. Podocin homooligomerizes through C-terminal helical regions [1] and binds nephrin in the glomerular slit diaphragm [2].
Violetta Antal-Kónya, Domonkos Pap, Gusztáv Schay, Máté Kétszeri, Anita Ungvári-Veres, Tivadar Tulassay, Miklós Kellermayer, Dóra Karancsiné Menyhárd, Kálmán Tory   +8 more
openaire   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved glycemic control and reduced blood pressure [PDF]

, 2016
Pharmacological blockade of the N-and L-type calcium channel lessens renal injury in kidney disease patients. The significance of specific blockade of α1 subunit of N-type calcium channel, Cav2.2, in diabetic nephropathy, however, remains to be clarified.
Fujikura, Junji, Imamaki, Hirotaka, Ishii, Akira, Kasahara, Masato, Kuwabara, Takashige, Kuwahara, Koichiro, Mori, Kiyoshi, Mori, Yasuo, Mukoyama, Masashi, Naito, Masaki, Nakao, Kazuwa, Numata, Tomohiro, Ohno, Shoko, Saleem, Moin, Yanagita, Motoko, Yokoi, Hideki   +15 more
core   +4 more sources

IL‐15 Links Muscle–Kidney Crosstalk to Preserving Podocyte Mitochondrial Fusion and Attenuating Diabetic Nephropathy

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Objectives High glucose induces mitochondrial dysfunction in podocytes, contributing to the development of diabetic nephropathy (DN). There is increasing evidence that muscles play a protective role by secreting myokines into the kidneys. Here, we investigated how skeletal muscle influences podocyte health via muscle–kidney crosstalk.
Yin Li, Jialing Rao, Weiyan Lai, Yuxiang Sun, Hongchun Lin, Jun Zhang, Zengchun Ye, Zhaoyong Hu, Hui Peng   +8 more
wiley   +1 more source

Urinary Excretion of Nephrin in Patients with Severe Preeclampsia

Hypertension in Pregnancy, 2010
The objective of this study was to examine whether nephrin is present in the urine of patients with severe preeclampsia.A total of 45 women were recruited for this study, and 25 of these patients had severe preeclampsia. Twenty gestational age-matched normotensive women without proteinuria served as a control group.
Ga Hyun, Son, Jeong Hyeon, Kim, Jung Hae, Hwang, Young Han, Kim, Yong Won, Park, Ja Young, Kwon   +5 more
openaire   +3 more sources

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, Volume 15, Issue 11, 20 March 2026.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source

Eluate derived by extracorporal antibody-based immunoadsorption elevates the cytosolic Ca2+ concentration in podocytes via B-2 kinin receptors [PDF]

, 2002
Background/Aim: Patients with idiopathic focal segmental glomerulosclerosis (FSGS) often develop a recurrence of the disease after kidney transplantation.
Fink, E., Fischer, K. G., Henger, A., Huber, T. B., Pavenstadt, H., Rump, L. C., Schwertfeger, E.   +6 more
core   +1 more source

Extracellular Vesicles in Autoimmune Diseases: From Diagnostic Biomarkers to Engineered Therapeutics

Advanced Science, Volume 13, Issue 18, 27 March 2026.
This review provides a systematic comparison of extracellular vesicles (EVs) from both mammalian and plant sources in the context of autoimmune diseases. It highlights their emerging roles as precision biomarkers and engineered therapeutic platforms.
Yufei Wu, Huiyuan Ma, Tinghui Zhu, Shuwei Huang, Manxi Lu, Qiong Wang, Zai‐Long Chi   +6 more
wiley   +1 more source