Results 71 to 80 of about 12,068 (208)

Urinary Excretion of Nephrin in Patients with Severe Preeclampsia

Hypertension in Pregnancy, 2010
The objective of this study was to examine whether nephrin is present in the urine of patients with severe preeclampsia.A total of 45 women were recruited for this study, and 25 of these patients had severe preeclampsia. Twenty gestational age-matched normotensive women without proteinuria served as a control group.
Ga Hyun, Son, Jeong Hyeon, Kim, Jung Hae, Hwang, Young Han, Kim, Yong Won, Park, Ja Young, Kwon   +5 more
openaire   +3 more sources

SETDB2 Mitigates Podocyte Dysfunction in Diabetic Kidney Disease Through Epigenetic Silencing of SMAD3

Advanced Science, Volume 13, Issue 9, 13 February 2026.
SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li, Shimin Jiang, Qi Jin, Peng Qu, Yingjie Guo, Xushan Lan, Xinyu Li, Cuiting Sun, Sinan Ai, Xin Li, Weiliang Sun, Jing Guo, Wenge Li, Liang Peng, Lihong Liu   +14 more
wiley   +1 more source

Therapeutic Potential of Mesenchymal Stem Cells in Pediatric Kidney Disorders: A Comprehensive Review

Health Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background Kidney diseases in children present significant health challenges, often leading to complications and reduced quality of life. Mesenchymal stem cell (MSC) therapy shows promise for pediatric kidney disorders. This review evaluates current evidence on MSC applications in pediatric nephrology, focusing on mechanisms, delivery methods,
Mahboube Bahroudi, Mastaneh Moghtaderi
wiley   +1 more source

Cloning and Expression of the Rat Nephrin Homolog [PDF]

The American Journal of Pathology, 1999
Despite of the increased availability of genetically modified mouse strains, the experimental models in the rat have provided the most widely employed and versatile models for the study of renal pathophysiology and functional genetics. The identification of the human gene mutated in the congenital nephrotic syndrome of the Finnish type (NPHS1) has ...
H, Ahola, S X, Wang, P, Luimula, M L, Solin, L B, Holzman, H, Holthöfer   +5 more
openaire   +2 more sources

Impaired NEPHRIN localization in kidney organoids derived from nephrotic patient iPS cells

Scientific Reports, 2021
Mutations in the NPHS1 gene, which encodes NEPHRIN, cause congenital nephrotic syndrome, resulting from impaired slit diaphragm (SD) formation in glomerular podocytes.
Tomoko Ohmori, Shankhajit De, Shunsuke Tanigawa, Koichiro Miike, Mazharul Islam, Minami Soga, Takumi Era, Shinichi Shiona, Koichi Nakanishi, Hitoshi Nakazato, Ryuichi Nishinakamura   +10 more
doaj   +1 more source

VEGF-A165b protects against proteinuria in a mouse model with progressive depletion of all endogenous VEGF-A splice isoforms from the kidney [PDF]

, 2017
Chronic kidney disease (CKD) is strongly associated with a decrease in the expression of VEGF-A. However, little is known about the contribution of VEGF-A splice isoforms to kidney physiology and pathology.
Allison, Bates, Bevan, Cebe Suarez, Chen, Cross, Cumpanas, Eremina, Eremina, Go, Harper, Kawamura, Martini, Matsushita, Meguid El Nahas, Menini, Ollero, Oltean, Oltean, Oshikawa, Qiu, Salmon, Satchell, Schrijvers, Seong, Sivaskandarajah, Snyder, Veron, Zheng   +28 more
core   +4 more sources

Liquid–Liquid Phase Separation in Major Hallmarks of Cancer

Cell Proliferation, Volume 59, Issue 2, February 2026.
Aberrant condensates formed through phase separation are involved in the dysregulation of various critical cellular processes, including genome stability, transcriptional regulation and signal transduction, thereby promoting malignant transformation and the acquisition of multiple cancer hallmarks.
Chen‐chen Xie, Ting Wang, Xin‐ran Liu, Yan Wang, Qin Dang, Tian Ding, Jia‐qi Xu, Xian‐jun Yu, Hai Lin, Xiao‐wu Xu, Yi Qin   +10 more
wiley   +1 more source

Organoids from Nephrotic Disease-Derived iPSCs Identify Impaired NEPHRIN Localization and Slit Diaphragm Formation in Kidney Podocytes

Stem Cell Reports, 2018
Summary: Mutations in the NPHS1 gene, which encodes NEPHRIN, cause congenital nephrotic syndrome, resulting from impaired slit diaphragm (SD) formation in glomerular podocytes.
Shunsuke Tanigawa, Mazharul Islam, Sazia Sharmin, Hidekazu Naganuma, Yasuhiro Yoshimura, Fahim Haque, Takumi Era, Hitoshi Nakazato, Koichi Nakanishi, Tetsushi Sakuma, Takashi Yamamoto, Hidetake Kurihara, Atsuhiro Taguchi, Ryuichi Nishinakamura   +13 more
doaj   +1 more source

Identification and characterization of novel glomerulus-associated genes and proteins [PDF]

, 2010
The kidney is responsible for sieving the circulating blood to eliminate water-soluble waste products and potentially toxic substances from the body. The filtration step occurs in specialized filtration units called glomeruli.
Xiao, Zhijie
core  

Family of neural wiring receptors in bilaterians defined by phylogenetic, biochemical, and structural evidence [PDF]

, 2019
The evolution of complex nervous systems was accompanied by the expansion of numerous protein families, including cell-adhesion molecules, surface receptors, and their ligands. These proteins mediate axonal guidance, synapse targeting, and other neuronal
Cheng, Shouqiang, Jeon, Mili, Kurleto, Justyna D., Park, Yeonwoo, Thornton, Joseph W., Zinn, Kai, Özkan, Engin   +6 more
core   +3 more sources