Results 71 to 80 of about 12,065 (211)

Impaired NEPHRIN localization in kidney organoids derived from nephrotic patient iPS cells

Scientific Reports, 2021
Mutations in the NPHS1 gene, which encodes NEPHRIN, cause congenital nephrotic syndrome, resulting from impaired slit diaphragm (SD) formation in glomerular podocytes.
Tomoko Ohmori, Shankhajit De, Shunsuke Tanigawa, Koichiro Miike, Mazharul Islam, Minami Soga, Takumi Era, Shinichi Shiona, Koichi Nakanishi, Hitoshi Nakazato, Ryuichi Nishinakamura   +10 more
doaj   +1 more source

Identification and characterization of novel glomerulus-associated genes and proteins [PDF]

, 2010
The kidney is responsible for sieving the circulating blood to eliminate water-soluble waste products and potentially toxic substances from the body. The filtration step occurs in specialized filtration units called glomeruli.
Xiao, Zhijie
core  

Cloning and Expression of the Rat Nephrin Homolog [PDF]

The American Journal of Pathology, 1999
Despite of the increased availability of genetically modified mouse strains, the experimental models in the rat have provided the most widely employed and versatile models for the study of renal pathophysiology and functional genetics. The identification of the human gene mutated in the congenital nephrotic syndrome of the Finnish type (NPHS1) has ...
H, Ahola, S X, Wang, P, Luimula, M L, Solin, L B, Holzman, H, Holthöfer   +5 more
openaire   +2 more sources

Comparative Genomics of Pinna rudis and Pinna nobilis Reveals Conserved and Divergent Features of the Bivalve Defensome

Ecology and Evolution, Volume 16, Issue 3, March 2026.
We present the first high‐quality annotated genome of Pinna rudis and an updated genome assembly for Pinna nobilis, two Mediterranean fan mussel species differentially affected by mass mortality events. Comparative genomic analyses of gene sets associated with the “defensome” show that these genes are largely functionally conserved between the two ...
Stéphane Coupé, Mathieu Foulquié, Maite Vázquez Luis, Elvira Alvarez Perez, Jean‐Marc Prévot, Nardo Vicente, Robert Bunet   +6 more
wiley   +1 more source

Organoids from Nephrotic Disease-Derived iPSCs Identify Impaired NEPHRIN Localization and Slit Diaphragm Formation in Kidney Podocytes

Stem Cell Reports, 2018
Summary: Mutations in the NPHS1 gene, which encodes NEPHRIN, cause congenital nephrotic syndrome, resulting from impaired slit diaphragm (SD) formation in glomerular podocytes.
Shunsuke Tanigawa, Mazharul Islam, Sazia Sharmin, Hidekazu Naganuma, Yasuhiro Yoshimura, Fahim Haque, Takumi Era, Hitoshi Nakazato, Koichi Nakanishi, Tetsushi Sakuma, Takashi Yamamoto, Hidetake Kurihara, Atsuhiro Taguchi, Ryuichi Nishinakamura   +13 more
doaj   +1 more source

VEGF-A165b protects against proteinuria in a mouse model with progressive depletion of all endogenous VEGF-A splice isoforms from the kidney [PDF]

, 2017
Chronic kidney disease (CKD) is strongly associated with a decrease in the expression of VEGF-A. However, little is known about the contribution of VEGF-A splice isoforms to kidney physiology and pathology.
Allison, Bates, Bevan, Cebe Suarez, Chen, Cross, Cumpanas, Eremina, Eremina, Go, Harper, Kawamura, Martini, Matsushita, Meguid El Nahas, Menini, Ollero, Oltean, Oltean, Oshikawa, Qiu, Salmon, Satchell, Schrijvers, Seong, Sivaskandarajah, Snyder, Veron, Zheng   +28 more
core   +4 more sources

Podocyte‐Derived Extracellular Vesicles Induce Endothelial Dysfunction by Triggering ER Stress in Glomerular Disease

Journal of Extracellular Vesicles, Volume 15, Issue 3, March 2026.
ABSTRACT Podocyte injury and endothelial cell dysfunction are the hallmarks of glomerular disease. How these two events are connected remains largely unknown. This study aimed to delineate the role of extracellular vesicles (EVs) in mediating podocyte‐endothelial communication in glomerular disease.
Zhao Liu, Xi Liu, Xin Wen, Siyu Yan, Meizhi He, Jie Xu, Zhanji Zhan, Haili Zhu, Huishi Tan, Nan Jia, Youhua Liu   +10 more
wiley   +1 more source

Family of neural wiring receptors in bilaterians defined by phylogenetic, biochemical, and structural evidence [PDF]

, 2019
The evolution of complex nervous systems was accompanied by the expansion of numerous protein families, including cell-adhesion molecules, surface receptors, and their ligands. These proteins mediate axonal guidance, synapse targeting, and other neuronal
Cheng, Shouqiang, Jeon, Mili, Kurleto, Justyna D., Park, Yeonwoo, Thornton, Joseph W., Zinn, Kai, Özkan, Engin   +6 more
core   +3 more sources

Remodeling the Inflammatory Microenvironment: Nanomaterial‐Based Targeted Strategies for Systemic Lupus Erythematosus and Lupus Nephritis

Small Science, Volume 6, Issue 3, March 2026.
Current treatments for severe lupus nephritis are limited by side effects due to poor drug targeting. This review explores how smart nanomaterials—like liposomes and biomimetic carriers—can precisely deliver drugs to overactive immune cells and the kidneys. These nanotherapeutics enhance efficacy, reduce toxicity, and enable combination strategies. The
Cheng Zhou, Jiayi Li, Jian Zhang, Haifeng Wang, Haitao Lu, Shunlai Shang, Wenge Li   +6 more
wiley   +1 more source

Erk5 is a mediator to TGFβ1-induced loss of phenotype and function in human podocytes. [PDF]

, 2014
Background: Podocytes are highly specialized cells integral to the normal functioning kidney, however, in diabetic nephropathy injury occurs leading to a compromised phenotype and podocyte dysfunction which critically produces podocyte loss with ...
Binder, Browne, Chuang, Dalla Vestra, Dessapt, Dorado, Drew, Fioretto, Gagliardini, Goldfarb, Hayashi, Herbach, Herman-Edelstein, Huang, Iwano, Khalil, Kim, Kim, Li, Maeda, Marchetti, Niculescu-Duvaz, Pavenstädt, Phanish, Reeves, Regan, Rocco, Saleem, Schiffer, Shishido, Siegel, Suzaki, Vardouli, Wahab, Winn, Woo, Wu, Zhou, Ziyadeh, Ziyadeh   +39 more
core   +2 more sources