Results 31 to 40 of about 422 (124)

Histopathological and Biochemical Comparative Study of Copper Oxide Nanoparticles and Copper Sulphate Toxicity in Male Albino Mice Reproductive System

International Journal of Biomaterials, Volume 2022, Issue 1, 2022., 2022
Copper (Cu) is an essential trace element for the efficient functioning of living organisms. Cu can enter the body in different ways, and when it surpasses the range of biological tolerance, it can have negative consequences. The use of different nanoparticles, especially metal oxide nanoparticles, is increasingly being expanded in the fields of ...
Manal M. S. AL-Musawi, Hanady Al-Shmgani, Genan A. Al-Bairuty, Sameh Ali   +3 more
wiley   +1 more source

Gandi Capsule Improved Podocyte Lipid Metabolism of Diabetic Nephropathy Mice through SIRT1/AMPK/HNF4A Pathway

Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022
Podocyte lipid accumulation is a potential therapeutic target for diabetic nephropathy (DN). This study was aimed at clarifying the mechanism of Gandi capsule (GDC) ameliorating DN by regulating the lipid metabolism of podocytes. Network pharmacology methods were performed to screen the key molecules and potential targets of GDC for constructing the ...
Ying Zhang, Huijuan Yao, Chao Li, Wei Sun, Xiaofei Chen, Yan Cao, Yue Liu, Yan Liu, Jihui Chen, Jia Qi, Qiqiang Zhang, Hai Zhang, Ajing Xu, Jian Zhang, Valentina Pallottini   +14 more
wiley   +1 more source

Functional study of mammalian Neph proteins in Drosophila melanogaster. [PDF]

PLoS ONE, 2012
Neph molecules are highly conserved immunoglobulin superfamily proteins (IgSF) which are essential for multiple morphogenetic processes, including glomerular development in mammals and neuronal as well as nephrocyte development in D. melanogaster.
Martin Helmstädter, Kevin Lüthy, Markus Gödel, Matias Simons, Ashish, Deepak Nihalani, Stefan A Rensing, Karl-Friedrich Fischbach, Tobias B Huber   +8 more
doaj   +1 more source

Exosomal microRNA‐16‐5p from human urine‐derived stem cells ameliorates diabetic nephropathy through protection of podocyte

Journal of Cellular and Molecular Medicine, Volume 25, Issue 23, Page 10798-10813, December 2021., 2021
Abstract Diabetic nephropathy (DN) remains one of the severe complications associated with diabetes mellitus. It is worthwhile to uncover the underlying mechanisms of clinical benefits of human urine‐derived stem cells (hUSCs) in the treatment of DN. At present, the clinical benefits associated with hUSCs in the treatment of DN remains unclear.
Yu‐Rui Duan, Bao‐Ping Chen, Fang Chen, Su‐Xia Yang, Chao‐Yang Zhu, Ya‐Li Ma, Yang Li, Jun Shi   +7 more
wiley   +1 more source

Modeling Podocyte Biology Using Drosophila Nephrocytes [PDF]

, 2019
Vertebrate podocytes are kidney glomerular cells critically required for normal renal filtration. To fulfill their role, podocytes form molecular sieves known as slit diaphragms that contribute to the glomerular filtration barrier. The disruption of podocyte biology or slit diaphragm formation in humans is a precursor to albuminuria, renal failure, and
Hartley, Paul S, Coward, Richard J
openaire   +3 more sources

ω‐3 Polyunsaturated Fatty Acids Facilitate the Repair of Peripheral Nerve Defects with Chemically Extracted Acellular Allograft in Rats

BioMed Research International, Volume 2021, Issue 1, 2021., 2021
Acellular allograft (ACA) improves the repair and reconstruction of long peripheral nerve defects. ω‐3 Polyunsaturated fatty acids (PUFAs) carry a neuroprotective potential, and their effects on ACA bridging were elucidated. Thirty rats with long gap sciatic nerve defects (15 mm long) were randomly divided into three groups (n = 10): ACA, ACA + PUFAs ...
Jun Zuo, Yuan Wu, Renkun Xiang, Zhiping Dai, Yi Zhu, Jafri Malin Abdullah   +5 more
wiley   +1 more source

Xianling Gubao Capsule Prevents Cadmium‐Induced Kidney Injury

BioMed Research International, Volume 2021, Issue 1, 2021., 2021
Xianling Gubao Capsule (XGC), a kind of capsule preparation of Chinese herbal officially approved for sale by the National Medical Products Administration (NMPA), has the effect of tonifying kidney and strengthening bones. Although the impact of XGC in treating bone diseases has been widely studied, the effect of XGC in kidney injury is unknown yet ...
Jian Huang, Xiao-tong Ma, Duo-duo Xu, Bao-jin Yao, Da-qing Zhao, Xiang-yang Leng, Jia Liu, Fatma M. El-Demerdash   +7 more
wiley   +1 more source

Mesenchymal Stem Cells: An Overview of Their Potential in Cell‐Based Therapy for Diabetic Nephropathy

Stem Cells International, Volume 2021, Issue 1, 2021., 2021
Diabetic nephropathy (DN) is a devastating complication associated with diabetes mellitus, and it is the leading cause of end‐stage renal diseases (ESRD). Over the last few decades, numerous studies have reported the beneficial effects of stem cell administration, specifically mesenchymal stem or stromal cells (MSCs), on tissue repair and regeneration.
Yan Wu, Chunlei Zhang, Ran Guo, Dan Wu, Jiayi Shi, Luxin Li, Yanhui Chu, Xiaohuan Yuan, Jie Gao, Adam Ye   +9 more
wiley   +1 more source

BRIDGING THE NEPHROCYTE GAP [PDF]

Journal of Experimental Biology, 2009
![Figure][1] The kidney is one of the main sites of blood volume regulation, osmoregulation and excretion in vertebrates. Its functional unit is the nephron, which can be found in countless copies in the kidney.
openaire   +1 more source

Comprehensive functional analysis of Rab GTPases in Drosophila nephrocytes [PDF]

Cell and Tissue Research, 2017
The Drosophila nephrocyte is a critical component of the fly renal system and bears structural and functional homology to podocytes and proximal tubule cells of the mammalian kidney. Investigations of nephrocyte cell biological processes are fundamental to understanding the insect renal system.
Yulong, Fu, Jun-Yi, Zhu, Fujian, Zhang, Adam, Richman, Zhanzheng, Zhao, Zhe, Han   +5 more
openaire   +2 more sources