Store operated calcium entry (SOCE) mediates insect nephrocyte clearance function [PDF]
, 2021 Insect nephrocytes are highly endocytic cells which remove proteins and xenotoxins from circulation (Figure 1). They express evolutionarily conserved ‘slit diaphragms’ at their surface; ultrastructures also expressed by mammalian kidney podocytes ...
Clarke, C. +2 more
core +1 more source
The Drosophila nephrocyte: back on stage. [PDF]
Journal of the American Society of Nephrology, 2013 Drosophila nephrocytes have been an object of study for more than a century. They were named by Bruntz, based on observations of cells around the heart, the central nervous system, and in the sternal area in scorpions.[1][1] Kowalevsky suggested that they function as a storage kidney, because ...
Jianbo Na, R. Cagan
semanticscholar +3 more sources
Insect nephrocyte function is regulated by a store operated calcium entry mechanism controlling endocytosis and Amnionless turnover. [PDF]
Journal of insect physiology, 2022 Insect nephrocytes are ultrafiltration cells that remove circulating proteins and exogenous toxins from the haemolymph. Experimental disruption of nephrocyte development or function leads to systemic impairment of insect physiology as evidenced by ...
S. Sivakumar +3 more
semanticscholar +4 more sources
The Drosophila nephrocyte has a glomerular filtration system. [PDF]
Nature Reviews Nephrology, 2014 Fujian Zhang, Xiangmei Chen
semanticscholar +4 more sources
BRIDGING THE NEPHROCYTE GAP [PDF]
Journal of Experimental Biology, 2009 ![Figure][1] The kidney is one of the main sites of blood volume regulation, osmoregulation and excretion in vertebrates. Its functional unit is the nephron, which can be found in countless copies in the kidney.
H. Merzendorfer
semanticscholar +2 more sources
Exploring the relevance of NUP93 variants in steroid-resistant nephrotic syndrome using next generation sequencing and a fly kidney model. [PDF]
Pediatr Nephrol, 2022 Background: Variants in genes encoding nuclear pore complex (NPC) proteins are a newly identified cause of paediatric steroid-resistant nephrotic syndrome (SRNS).
Bierzynska A +23 more
europepmc +9 more sources
A SNARE protective pool antagonizes APOL1 renal toxicity in Drosophila nephrocytes. [PDF]
Cell Biosci, 2023 Abstract Background People of Sub-Saharan African ancestry are at higher risk of developing chronic kidney disease (CKD), attributed to the Apolipoprotein L1 (APOL1) gene risk alleles (RA) G1 and G2. The underlying mechanisms by which the APOL1-RA precipitate CKD remain elusive, hindering the development of potential ...
Lee JG +6 more
europepmc +4 more sources
Combined transcriptome and proteome profiling reveal cell-type-specific functions of Drosophila garland and pericardial nephrocytes. [PDF]
Commun BiolDrosophila nephrocytes are specialised cells that share critical functional, morphological, and molecular features with mammalian podocytes. Accordingly, nephrocytes represent a preferred invertebrate model for human glomerular disease.
Meyer H +6 more
europepmc +3 more sources
Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency [PDF]
, 2017 Steroid-resistant nephrotic syndrome (SRNS) causes 15% of chronic kidney disease cases. A mutation in 1 of over 40 monogenic genes can be detected in approximately 30% of individuals with SRNS whose symptoms manifest before 25 years of age.
Connolly, Anne M +4 more
core +6 more sources