Results 101 to 110 of about 3,007 (176)

Prrx1-driven LINC complex disruption in vivo reduces osteoid deposition but not bone quality after voluntary wheel running.

PLoS ONE
The Linker of Nucleoskeleton and Cytoskeleton (LINC) complex serves to connect the nuclear envelope and the cytoskeleton, influencing cellular processes such as nuclear arrangement, architecture, and mechanotransduction.
Scott Birks, Sean Howard, Christian S Wright, Caroline O'Rourke, Elicza A Day, Alexander J Lamb, James R Walsdorf, Anthony Lau, William R Thompson, Gunes Uzer   +9 more
doaj   +1 more source

Nesprin-1 expression is highly adaptable.

, 2012
Expression levels of N1-3′E87, N1-3′E90 and nesprin-1 KASH domain were monitored post-siRNA knockdown using siRNAs targeting exons 90 and 136 of the nesprin-1 gene.
Jason A. Mellad (154523), Flavia Autore (154527), Qiuping Zhang (154532), Catherine M. Shanahan (154536), Dipen Rajgor (154519)   +4 more
core   +1 more source

LINC complex alterations are a key feature of sporadic and familial ALS/FTD

Acta Neuropathologica Communications
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that primarily affects motor neurons, leading to progressive muscle weakness and loss of voluntary muscle control. While the exact cause of ALS is not fully understood, emerging research
Riccardo Sirtori, Michelle J. Gregoire, Emily M. Potts, Alicia Collins, Liviana Donatelli, Claudia Fallini   +5 more
doaj   +1 more source

Mechanical load as an endogenous tumor suppressor: Nesprin-2-mediated mechanotransduction reshapes the cancer epigenome. [PDF]

Signal Transduct Target Ther
Papavassiliou KA, Papavassiliou AG.
europepmc   +1 more source

Exploring the Role of Nesprin1 in isoproterenol-induced heart failure: Insights into pathogenesis and therapeutic implications. [PDF]

PLoS One
Qin Q, Dong C, Zhou Z, Liu Y, Liu M, Cao C, Teng L.   +6 more
europepmc   +1 more source

A Novel Emerin/Nesprin-3 Interaction Mediates Nuclear Size Changes Induced by Oncogenic KRAS in Pancreatic Cancer Cells. [PDF]

Mol Cell Biol
LaRue-Nolan KC, Flores LF, Vera RE, Sigafoos AN, Hilario Garcia L, Almada LL, Tader BR, Rodriguez-Quevedo MF, May DG, Marks DL, Roux KJ, Fernandez-Zapico ME.   +11 more
europepmc   +1 more source

AKAP6β-a conductor in the orchestra of pathological cardiomyocyte gene transcription. [PDF]

Mol Pharmacol
Aydin S, Kapiloff MS, Dodge-Kafka KL.
europepmc   +1 more source

Cargo Recognition of Nesprin-2 by the Dynein Adapter Bicaudal D2 for a Nuclear Positioning Pathway That Is Important for Brain Development. [PDF]

Biochemistry
Rodriguez Castro ED, Putta S, Ali MY, Garcia Martin JM, Zhao X, Sylvain S, Trybus KM, Solmaz SR.   +7 more
europepmc   +1 more source

Mechanical forces of beating heart suppress cancer growth. [PDF]

Mechanobiol Med
Li T, Liu Y.
europepmc   +1 more source

Age-related decline in nuclear envelope LINC complex drives neuronal aging via axon initial segment dysfunction. [PDF]

EMBO Rep
Hasegawa K, Hama N, Amemiya M, Zeng C, Ito Y, Suzuki S, Nakamura K, Kondo J, Takeda C, Kurihara Y, Ikeda K, Fujita Y, Okada Y, Toyoda A, Hamada M, Kuwako KI.   +15 more
europepmc   +1 more source