Results 91 to 100 of about 3,007 (176)

Neonatal AAV gene therapy rescues hearing in a mouse model of SYNE4 deafness

EMBO Molecular Medicine, 2020
Genetic variants account for approximately half the cases of congenital and early‐onset deafness. Methods and technologies for viral delivery of genes into the inner ear have evolved over the past decade to render gene therapy a viable and attractive ...
Shahar Taiber, Roie Cohen, Ofer Yizhar‐Barnea, David Sprinzak, Jeffrey R Holt, Karen B Avraham   +5 more
doaj   +1 more source

Short forms of nesprin-1 and nesprin-2.

, 2014
Pictorial representation of nesprin-1-giant and nesprin-2-giant with the N-terminal start points of the smaller isoforms indicated by black lines and arrows. Isoforms that we found present at low levels are labelled in grey.
Le Thanh Lam (33460), Ian Holt (263855), Glenn E. Morris (263861), Caroline A. Sewry (337771), Qiuping Zhang (154532), Catherine M. Shanahan (154536), Nguyen Thuy Duong (549559)   +6 more
core   +1 more source

GFP-nesprin-2 accumulation

, 2019
Data obtained and analyzed for a manuscript on GFP-nesprin-2 accumulation.
Davidson, P
core   +2 more sources

Mechanical regulation of LINC complex function: structural basis, physiological roles, and disease mechanisms in transnuclear mechanotransduction

Frontiers in Cell and Developmental Biology
How mechanical stimuli cross the nuclear envelope and are converted into nuclear structural and transcriptional responses is a central question in understanding cellular mechanical adaptation and its failure. The LINC complex is composed of inner nuclear
Shuoshuo Shao, Zhu Zhu, Huaiquan Liu
doaj   +1 more source

Implications for Diverse Functions of the LINC Complexes Based on the Structure

Cells, 2017
The linker of nucleoskeleton and cytoskeleton (LINC) complex is composed of the outer and inner nuclear membrane protein families Klarsicht, Anc-1, and Syne homology (KASH), and Sad1 and UNC-84 (SUN) homology domain proteins.
Miki Hieda
doaj   +1 more source

Identification of novel nesprin UTRs.

, 2012
A) cDNA ends identified by 3′ and 5′ RACE from Brain, Skeletal Muscle (SkeMus) and HeLa cDNA libraries. B) DNA sequencing results suggest that nesprin isoforms terminate with unique C-terminal ends absent from the giant isoforms as a result of intron ...
Jason A. Mellad (154523), Flavia Autore (154527), Qiuping Zhang (154532), Catherine M. Shanahan (154536), Dipen Rajgor (154519)   +4 more
core   +1 more source

Nuclear membrane protein SUN2 promotes replication of flaviviruses through modulating cytoskeleton reorganization mediated by NS1

Nature Communications
Cytoskeleton is extensively recruited by flaviviruses for their infection. In this study, we uncovered an essential role of a nuclear membrane protein, SAD1/UNC84 domain protein 2 (SUN2) linking cytoskeleton and nucleoskeleton in the flavivirus ...
Yanxia Huang, Qinyu Peng, Xu Tian, Cancan Chen, Xuanfeng Zhu, Changbai Huang, Zhiting Huo, Yang Liu, Chao Yang, Chao Liu, Ping Zhang   +10 more
doaj   +1 more source

Nesprin-2 contains BH3-like motifs that can promote cell death

Cell Death Discovery
BH3-only proteins are a subgroup of the pro-apoptotic Bcl-2 family proteins. They initiate apoptosis by interacting with the multidomain pro- and anti-apoptotic Bcl-2 family proteins.
Hila Zohar, Amit Kessel, Liora Lindenboim, Dang Nguyen, Nir Ben-Tal, Gregg G. Gundersen, Howard J. Worman, David W. Andrews, Reuven Stein   +8 more
doaj   +1 more source

Nesprin-1 [PDF]

, 2020
openaire   +1 more source

Nesprin-2 [PDF]

, 2020
openaire   +1 more source