Results 71 to 80 of about 3,007 (176)
Mammalian microtubule P-body dynamics are mediated by nesprin-1 [PDF]
Journal of Cell Biology, 2014 Nesprins are a multi-isomeric family of spectrin-repeat (SR) proteins, predominantly known as nuclear envelope scaffolds. However, isoforms that function beyond the nuclear envelope remain poorly examined. Here, we characterize p50Nesp1, a 50-kD isoform that localizes to processing bodies (PBs), where it acts as a microtubule-associated protein capable
Rajgor, Dipen +5 more
openaire +4 more sources
LINC complex protein nesprin-2 has pro-apoptotic activity via Bcl-2 family proteins
Cell Death DiscoveryThe apoptotic intrinsic pathway is initiated by perforation of the mitochondrial outer membrane by the effector pro-apoptotic proteins of the Bcl-2 family, Bax and Bak. Bax and Bak need to be activated, a process facilitated by the action of BH3-only pro-
Liora Lindenboim +4 more
doaj +1 more source
An Intronic Heterozygous SYNE2 Splice Site Mutation: A Rare Cause for Myalgia and hyperCKemia?
MusclesSYNE2 mutations have been associated with skeletal and cardiac muscle diseases, including Emery-Dreifuss muscular dystrophy (EDMD). Here, we present a 70-year-old male patient with muscle pain and elevated serum creatine kinase levels in whom whole-exome
Theresa Paulus +10 more
doaj +1 more source
Journal of Translational Medicine, 2020 Background Spectrin repeat containing nuclear envelope family member 3 (SYNE3) encodes an essential component of the linker of the cytoskeleton and nucleoskeleton (LINC) complex, namely nesprin-3.
Liwei Liao +10 more
doaj +1 more source
Sono‐Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology
Advanced Science, Volume 13, Issue 33, 15 June 2026.Sono‐mechanogenetics links ultrasound physics with cellular mechanotransduction to enable noninvasive control of engineered biological systems. Acoustic forces generate distinct deformation modes that activate intracellular signaling pathways, which can be coupled to synthetic gene circuits to regulate diverse cellular functions, including gene ...
Yunjia Qu +4 more
wiley +1 more source
Generation of nesprin-1 and nesprin-2 ΔKASH variants.
, 2012 A) Nesprin-1ΔKASH is generated through the removal of cassette exon 145, resulting in disruption of the KASH domain. Ectopically expressed p53ΔKASHNesp1 fails to localize to the NE in U2OS cells and is strongly concentrated within the nucleus and weakly ...
Jason A. Mellad (154523) +4 more
core +1 more source
Using Nesprin Tension Sensors to Measure Force on the LINC Complex [PDF]
, 2018 Mechanotransduction, or the process by which mechanical forces regulate cellular functions, is increasingly studied in a variety of different physiological and pathological contexts. Although these forces are most often studied at cell-matrix and cell-cell adhesions, recent work has shown that the nuclear LINC complex is also subject to mechanical ...
Paul T, Arsenovic, Daniel E, Conway
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Advanced Science, Volume 13, Issue 30, 28 May 2026.This work develops dynamically softening polyacrylamide hydrogels for time‐resolved imaging during continuous mechanical transitions. The study revealed that mechanotransduction is biphasic; YAP/TAZ inactivation is driven by early loss of the nucleocytoskeletal continuum connecting subnuclear adhesions, F‐actin, and the nuclear envelope, coupled with ...
Alessandro Gandin +12 more
wiley +1 more source
Stem Cell Research, 2019 Pluripotency of mouse embryonic stem cells is regulated by transcription factor regulatory networks as well as mechanical stimuli sensed by the cells.
Brit Gracy David +10 more
doaj +1 more source
, 2012 A) Genomic map of the nesprin-1 gene highlighting the positions of the nesprin-1 UTRs identified to date. B) Proposed nesprin-1 isoforms created by alternative transcription.
Jason A. Mellad (154523) +4 more
core +1 more source