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Current Biology, 2003 It is generally accepted that the vertebrates evolved from protochordates ancestors, probably from an animal akin to modern day Amphioxus, a sessile filter feeder whose anatomical organisation is in many ways very similar to that of vertebrates. It has a dorsal nerve cord, a notochord, segmented muscle blocks and pharyngeal gill slits, but it lacks ...
Anthony Graham
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Definitions, 2020 [3] neural crest cells [4] neurocristopathies [5] Early in the process of development, vertebrate embryos develop a fold on the neural plate [6] where the neural and epidermal ectoderms meet, called the neural crest [7] .
Julia Platt
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The origin and evolution of vertebrate neural crest cells [PDF]
Open Biology, 2020 The neural crest is a vertebrate-specific migratory stem cell population that generates a remarkably diverse set of cell types and structures. Because many of the morphological, physiological and behavioural novelties of vertebrates are derived from ...
Joshua R. York, David W. McCauley
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ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived cells [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Neuroblastoma is a pediatric tumor arising from the neural crest. Dysregulation of the receptor tyrosine kinase ALK has been linked to neuroblastoma, making it important to understand its function in native conditions.
Andrey Fadeev +9 more
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Wnt-signaling enhances neural crest migration of melanoma cells and induces an invasive phenotype [PDF]
Molecular Cancer, 2018 During embryonic development Wnt family members and bone morphogenetic proteins (BMPs) cooperatively induce epithelial-mesenchymal transition (EMT) in the neural crest. Wnt and BMPs are reactivated during malignant transformation in melanoma.
Tobias Sinnberg +8 more
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Cardiac neural crest contributes to cardiomyocytes in amniotes and heart regeneration in zebrafish
eLife, 2019 Cardiac neural crest cells contribute to important portions of the cardiovascular system including the aorticopulmonary septum and cardiac ganglion. Using replication incompetent avian retroviruses for precise high-resolution lineage analysis, we uncover
Weiyi Tang +3 more
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Advances in Experimental Medicine and BiologyThis chapter discusses the role of cardiac neural crest cells in the formation of the septum that divides the cardiac arterial pole into separate systemic and pulmonary arteries. Further, cardiac neural crest cells directly support the normal development and patterning of derivatives of the caudal pharyngeal arches, including the great arteries, thymus,
Bijoy D, Thattaliyath +1 more
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Enteric neurospheres are not specific to neural crest cultures: implications for neural stem cell therapies. [PDF]
PLoS ONE, 2015 Enteric neural stem cells provide hope of curative treatment for enteric neuropathies. Current protocols for their harvesting from humans focus on the generation of 'neurospheres' from cultures of dissociated gut tissue.
Ellen Binder +8 more
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Eed controls craniofacial osteoblast differentiation and mesenchymal proliferation from the neural crest [PDF]
eLifeThe histone methyltransferase Polycomb repressive complex 2 (PRC2) is required for specification of the neural crest, and mis-regulation of neural crest development can cause severe congenital malformations. PRC2 is necessary for neural crest induction,
Tim Casey-Clyde +9 more
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Frontiers in Physiology, 2020 Sox transcription factors play many diverse roles during development, including regulating stem cell states, directing differentiation, and influencing the local chromatin landscape.
Elizabeth N. Schock +2 more
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