Results 21 to 30 of about 1,925,336 (327)
Stem Cell Research, 2020 Neural crest cells are an embryonic multipotent stem cell population. Recent studies in model organisms have suggested that neural crest cells are specified earlier than previously thought, at blastula stages.
Maneeshi S. Prasad +3 more
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Protein tyrosine phosphatase 4A3 (PTP4A3) is required for Xenopus laevis cranial neural crest migration in vivo. [PDF]
PLoS ONE, 2013 Uveal melanoma is the most common intraocular malignancy in adults, representing between about 4% and 5% of all melanomas. High expression levels of Protein Tyrosine Phosphatase 4A3, a dual phosphatase, is highly predictive of metastasis development and ...
Selma Maacha +7 more
doaj +1 more source
Xenopus Nkx6.3 is a neural plate border specifier required for neural crest development. [PDF]
PLoS ONE, 2014 In vertebrates, the neural plate border (NPB) is established by a group of transcription factors including Dlx3, Msx1 and Zic1. The crosstalk between these NPB specifiers governs the separation of the NPB region into placode and neural crest (NC ...
Zuming Zhang +5 more
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RNA-binding protein Elavl1/HuR is required for maintenance of cranial neural crest specification
eLife, 2022 While neural crest development is known to be transcriptionally controlled via sequential activation of gene regulatory networks (GRNs), recent evidence increasingly implicates a role for post-transcriptional regulation in modulating the output of these ...
Erica J Hutchins +4 more
doaj +1 more source
Neural crest development: insights from the zebrafish
Developmental Dynamics, 2020 Our understanding of the neural crest, a key vertebrate innovation, is built upon studies of multiple model organisms. Early research on neural crest cells (NCCs) was dominated by analyses of accessible amphibian and avian embryos, with mouse genetics ...
M. Rocha +4 more
semanticscholar +1 more source
Dual orexin and MCH neuron-ablated mice display severe sleep attacks and cataplexy
eLife, 2020 Orexin/hypocretin-producing and melanin-concentrating hormone-producing (MCH) neurons are co-extensive in the hypothalamus and project throughout the brain to regulate sleep/wakefulness.
Chi Jung Hung +3 more
doaj +1 more source
Transcriptomic Identification of Draxin-Responsive Targets During Cranial Neural Crest EMT
Frontiers in Physiology, 2021 Canonical Wnt signaling plays an essential role in proper craniofacial morphogenesis, at least partially due to regulation of various aspects of cranial neural crest development.
Erica J. Hutchins +2 more
doaj +1 more source
The heart of the neural crest: cardiac neural crest cells in development and regeneration
Development, 2020 Cardiac neural crest cells (cNCCs) are a migratory cell population that stem from the cranial portion of the neural tube. They undergo epithelial-to-mesenchymal transition and migrate through the developing embryo to give rise to portions of the outflow ...
Rajani M. George +2 more
semanticscholar +1 more source
Cranial Neural Crest Explants [PDF]
Cold Spring Harbor Protocols, 2018 The cranial neural crest (CNC) explant assay was originally designed to assess the basic requirements for CNC migration in vitro. This protocol describes the key parameters of CNC explants in Xenopus laevis, with a focus on how to extirpate CNC cells and assay their migration in vitro.
Hélène, Cousin, Dominique, Alfandari
openaire +2 more sources
Spatiotemporal structure of cell fate decisions in murine neural crest
Science, 2019 Binary decisions refine fate decisions Neural crest cells develop into tissues ranging from craniofacial bones to peripheral neurons. Combining single-cell RNA sequencing with spatial transcriptomics, Soldatov et al.
Ruslan A. Soldatov +27 more
semanticscholar +1 more source