Results 31 to 40 of about 2,622,049 (363)

Polycistronic Delivery of IL-10 and NT-3 Promotes Oligodendrocyte Myelination and Functional Recovery in a Mouse Spinal Cord Injury Model. [PDF]

, 2020
One million estimated cases of spinal cord injury (SCI) have been reported in the United States and repairing an injury has constituted a difficult clinical challenge.
Anderson, Aileen J, Ciciriello, Andrew J, Cummings, Brian J, Dumont, Courtney M, Guo, Amina, Park, Jonghyuck, Shea, Lonnie D, Smith, Dominique R, Tatineni, Ravindra   +8 more
core   +1 more source

Recent advances in the application of MXenes for neural tissue engineering and regeneration

Neural Regeneration Research, 2023
Transition metal carbides and nitrides (MXenes) are crystal nanomaterials with a number of surface functional groups such as fluorine, hydroxyl, and oxygen, which can be used as carriers for proteins and drugs.
Menghui Liao, Qingyue Cui, Yangnan Hu, Jiayue Xing, Danqi Wu, Shasha Zheng, Yu Zhao, Yafeng Yu, Jingwu Sun, R. Chai   +9 more
semanticscholar   +1 more source

Advances in Electrospun Nerve Guidance Conduits for Engineering Neural Regeneration

Pharmaceutics, 2022
Injuries to the peripheral nervous system result in devastating consequences with loss of motor and sensory function and lifelong impairments. Current treatments have largely relied on surgical procedures, including nerve autografts to repair damaged ...
S. Behtaj, J. Ekberg, J. S. St John
semanticscholar   +1 more source

Regulating Retinoic Acid Availability during Development and Regeneration: The Role of the CYP26 Enzymes. [PDF]

, 2020
This review focuses on the role of the Cytochrome p450 subfamily 26 (CYP26) retinoic acid (RA) degrading enzymes during development and regeneration. Cyp26 enzymes, along with retinoic acid synthesising enzymes, are absolutely required for RA homeostasis
Roberts, C
core   +1 more source

Improving the regenerative potential of olfactory ensheathing cells by overexpressing prostacyclin synthetase and its application in spinal cord repair

Journal of Biomedical Science, 2017
Background Olfactory ensheathing cells (OEC), specialized glia that ensheathe bundles of olfactory nerves, have been reported as a favorable substrate for axonal regeneration.
May-Jywan Tsai, Chi-Ting Huang, Yong-San Huang, Ching-Feng Weng, Song-Kun Shyue, Ming-Chao Huang, Dann-Ying Liou, Yan-Ru Lin, Chu-Hsun Cheng, Huai-Sheng Kuo, Yilo Lin, Meng-Jen Lee, Wen-Hung Huang, Wen-Cheng Huang, Henrich Cheng   +14 more
doaj   +1 more source

Machine‐Assisted Discovery of Chondroitinase ABC Complexes toward Sustained Neural Regeneration

Advanced Healthcare Materials, 2022
Among the many molecules that contribute to glial scarring, chondroitin sulfate proteoglycans (CSPGs) are known to be potent inhibitors of neuronal regeneration.
Shashank Kosuri, C. Borca, H. Mugnier, Matthew Tamasi, Roshan A. Patel, Isabel Perez, Suneel Kumar, Zachary Finkel, R. Schloss, L. Cai, M. Yarmush, Michael A. Webb, A. Gormley   +12 more
semanticscholar   +1 more source

NLRP3 deficiency decreases alcohol intake controlling anxiety-like behavior via modification of glutamatergic transmission in corticostriatal circuits

Journal of Neuroinflammation, 2022
Background Alcohol use disorders result from repeated binge and chronic alcohol consumption followed by negative effects, such as anxiety, upon cessation. This process is associated with the activation of NLRP3 inflammasome-mediated responses.
Ziyi Li, Olivia Ewi Vidjro, Gengni Guo, Yanfeng Du, Yao Zhou, Qian Xie, Jiaxin Li, Keqiang Gao, Li Zhou, Tengfei Ma   +9 more
doaj   +1 more source

6’-sialyllactose ameliorates the ototoxic effects of the aminoglycoside antibiotic neomycin in susceptible mice

Frontiers in Immunology, 2023
Sialic acids are terminal sugars of the cellular glycocalyx and are highly abundant in the nervous tissue. Sialylation is sensed by the innate immune system and acts as an inhibitory immune checkpoint.
Tawfik Abou Assale, Thomas Kuenzel, Tamara Schink, Anahita Shahraz, Harald Neumann, Christine Klaus   +5 more
doaj   +1 more source

Hyaluronan, neural stem cells and tissue reconstruction after acute ischemic stroke. [PDF]

, 2013
Focal stroke is a disabling disease with lifelong sensory, motor and cognitive impairments. Given the paucity of effective clinical treatments, basic scientists are developing novel options for protection of the affected brain and regeneration of lost ...
Carmichael, S Thomas, Moshayedi, Pouria
core   +1 more source

Determinants of Increased Fibrinogen in COVID-19 Patients With and Without Diabetes and Impaired Fasting Glucose

Clinical and Applied Thrombosis/Hemostasis, 2021
Background: To investigate the factors associated with elevated fibrinogen (Fbg) levels in COVID-19 patients with and without diabetes (DM) and impaired fasting glucose (IFG).
Zhenzhou Wang MD, Zhe Du MD, Xiujuan Zhao MD, Fuzheng Guo MD, Tianbing Wang MD, Fengxue Zhu MD   +5 more
doaj   +1 more source