Results 41 to 50 of about 2,564,857 (374)

Characterizing the Retinal Phenotype of the Thy1-h[A30P]α-syn Mouse Model of Parkinson’s Disease

Frontiers in Neuroscience, 2021
Despite decades of research, disease-modifying treatments of Parkinson’s disease (PD), the second most common neurodegenerative disease worldwide, remain out of reach.
Lien Veys, Lien Veys, Joyce Devroye, Joyce Devroye, Evy Lefevere, Evy Lefevere, Lien Cools, Lien Cools, Marjan Vandenabeele, Marjan Vandenabeele, Lies De Groef, Lies De Groef   +11 more
doaj   +1 more source

SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injury through NF-κB signaling

Theranostics, 2021
Axonal degeneration is a common pathological feature in many acute and chronic neurological diseases such as spinal cord injury (SCI). SARM1 (sterile alpha and TIR motif-containing 1), the fifth TLR (Toll-like receptor) adaptor, has diverse functions in ...
Huitao Liu, Jingjing Zhang, Xingxing Xu, Sheng Lu, Danlu Yang, Changnan Xie, Mengxian Jia, Wenbin Zhang, Lingting Jin, Xiwu Wang, Xiya Shen, Fayi Li, Wangfei Wang, Xiao-mei Bao, Sijia Li, Minyu Zhu, W. Wang, Ying Wang, Zhihui Huang, Honglin Teng   +19 more
semanticscholar   +1 more source

Depressive patient‐derived GABA interneurons reveal abnormal neural activity associated with HTR2C

EMBO Molecular Medicine, 2022
Major depressive disorder with suicide behavior (sMDD) is a severe mood disorder, bringing tremendous burden to family and society. Although reduced gamma amino butyric acid (GABA) level has been observed in postmortem tissues of sMDD patients, the ...
Kaiqin Lu, Yuan Hong, Mengdan Tao, Luping Shen, Zhilong Zheng, Kaiheng Fang, Fang Yuan, Min Xu, Chun Wang, Dongya Zhu, Xing Guo, Yan Liu   +11 more
doaj   +1 more source

Retinal Ganglion Cells: Global Number, Density and Vulnerability to Glaucomatous Injury in Common Laboratory Mice

Cells, 2022
How many RBPMS+ retinal ganglion cells (RGCs) does a standard C57BL/6 laboratory mouse have on average and is this number substrain- or sex-dependent? Do RGCs of (European) C57BL/6J and -N mice show a different intrinsic vulnerability upon glaucomatous ...
Marie Claes, Lieve Moons
doaj   +1 more source

Ischemic postconditioning ameliorates acute kidney injury induced by limb ischemia/reperfusion via transforming TLR4 and NF-κB signaling in rats

Journal of Orthopaedic Surgery and Research, 2021
Background The present study investigated the influence of ischemic postconditioning (I-postC) on the adjustment of renal injury after limb ischemia-reperfusion (I/R) injury, to elucidate the mechanisms of the Toll-like receptor 4 (TLR 4)/NF-κB signaling
Zhongdi Liu, Wei Huang, Yifan Chen, Zhe Du, Fengxue Zhu, Tianbing Wang, Baoguo Jiang   +6 more
doaj   +1 more source

Ischemic postconditioning protects against acute kidney injury after limb ischemia reperfusion by regulating HMGB1 release and autophagy

Renal Failure, 2023
Ischemic postconditioning (I-PostC) has a protective effect against acute kidney injury (AKI) induced by limb ischemia–reperfusion (LIR); however, the exact mechanism remains to be elucidated.
Zhongdi Liu, Yifan Chen, Zhe Du, Fengxue Zhu, Wei Huang   +4 more
doaj   +1 more source

Enhancing Nervous System Recovery through Neurobiologics, Neural Interface Training, and Neurorehabilitation. [PDF]

, 2016
After an initial period of recovery, human neurological injury has long been thought to be static. In order to improve quality of life for those suffering from stroke, spinal cord injury, or traumatic brain injury, researchers have been working to ...
Edgerton, V Reggie, Krucoff, Max O, Rahimpour, Shervin, Slutzky, Marc W, Turner, Dennis A   +4 more
core   +1 more source

Biohybrids for Neural Tracts Regeneration [PDF]

, 2021
[ES] Las lesiones del sistema nervioso que implican la interrupción de haces axonales son devastadoras para el individuo. La regeneración autónoma de los tractos axonales dañados o degenerados es poco frecuente, ya que intervienen una gran cantidad de factores que limitan esta recuperación.
openaire   +3 more sources

The HSPG Glypican Regulates Experience-Dependent Synaptic and Behavioral Plasticity by Modulating the Non-Canonical BMP Pathway

Cell Reports, 2019
Summary: Under food deprivation conditions, Drosophila larvae exhibit increases in locomotor speed and synaptic bouton numbers at neuromuscular junctions (NMJs).
Keisuke Kamimura, Aiko Odajima, Yuko Ikegawa, Chikako Maru, Nobuaki Maeda   +4 more
doaj   +1 more source

Potential use of human periapical cyst-mesenchymal stem cells (hPCy-MSCs) as a novel stem cell source for regenerative medicine applications [PDF]

, 2017
Mesenchymal stem cells (MSCs) are attracting growing interest by the scientific community due to their huge regenerative potential. Thus, the plasticity of MSCs strongly suggests the utilization of these cells for regenerative medicine applications.
Codispoti, Bruna, Marrelli, Massimo, Pacifici, Andrea, Pacifici, Luciano, Paduano, Francesco, Palmieri, Francesca, Tatullo, Marco   +6 more
core   +2 more sources