Results 41 to 50 of about 93,309 (296)

The killifish visual system as an in vivo model to study brain aging and rejuvenation

npj Aging and Mechanisms of Disease, 2021
Worldwide, people are getting older, and this prolonged lifespan unfortunately also results in an increased prevalence of age-related neurodegenerative diseases, contributing to a diminished life quality of elderly.
Sophie Vanhunsel, Steven Bergmans, An Beckers, Isabelle Etienne, Jolien Van houcke, Eve Seuntjens, Lut Arckens, Lies De Groef, Lieve Moons   +8 more
doaj   +1 more source

Sleep deprivation aggravated amyloid β oligomers-induced damage to the cerebellum of rats: Evidence from magnetic resonance imaging

Aging Brain, 2023
For quite a long time, researches on Alzheimer's disease (AD) primarily focused on the cortex and hippocampus, while the cerebellum has been ignored because of its abnormalities considered to appear in the late stage of AD.
Wensheng Guo, Xin Mao, Ding Han, Hongqi Wang, Wanning Zhang, Guitao Zhang, Ning Zhang, Binbin Nie, Hui Li, Yizhi Song, Yan Wu, Lirong Chang   +11 more
doaj   +1 more source

Harnessing migraines for neural regeneration

Neural Regeneration Research, 2018
The success of naturalistic or therapeutic neuroregeneration likely depends on an internal milieu that facilitates the survival, proliferation, migration, and differentiation of stem cells and their assimilation into neural networks. Migraine attacks are an integrated sequence of physiological processes that may protect the brain from oxidative stress ...
openaire   +4 more sources

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Redirecting regeneration [PDF]

Nature Reviews Neuroscience, 2015
In zebrafish, components of the extracellular matrix help to direct regenerating motor axons to their original targets.
openaire   +3 more sources

Neural Regeneration in Caenorhabditis elegans [PDF]

Annual Review of Genetics, 2012
Axon regeneration is a medically relevant process that can repair damaged neurons. This review describes current progress in understanding axon regeneration in the model organism Caenorhabditis elegans. Factors that regulate axon regeneration in C. elegans have broadly similar roles in vertebrate neurons. This means that using C.
Marc Hammarlund, Rachid El Bejjani
openaire   +3 more sources

Matrix: a complex amalgam of structures and functions in tumor microenvironment

FEBS Open Bio, EarlyView.
The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis, Evgenia Tsoukala, Theodora D. Sarantopoulou, Maria‐Elpida Christopoulou   +3 more
wiley   +1 more source

Genetically engineered BMSCs promote dopamine secretion and ameliorate motor dysfunction in a Parkinson’s disease rat model

Scientific Reports
Regenerative therapy based on mesenchymal stem cells (MSCs) is regarded as a promising strategy for treating Parkinson’s disease (PD). Previous studies have shown that mesenchymal stem cell transplantation has the potential to treat Parkinson’s disease ...
Chunjing Wang, Yang Liu, Junyan Chang, Yiqin He, Pan Yang, Jingjing Fu, Wanying Du, Caiyun Ma, Gaofeng Liu, Yu Guo, Changqing Liu   +10 more
doaj   +1 more source

Functional glutamate transporters are expressed in the carotid chemoreceptor

Respiratory Research, 2020
Background The carotid body (CB) plays a critical role in cyclic intermittent hypoxia (CIH)-induced chemosensitivity; however, the underlying mechanism remains uncertain. We have demonstrated the presence of multiple inotropic glutamate receptors (iGluRs)
Chaohong Li, Lu Huang, Xianglei Jia, Baosheng Zhao, Lingyun Chen, Yuzhen Liu   +5 more
doaj   +1 more source

Networking for regeneration [PDF]

Nature Reviews Neuroscience, 2016
A large collaborative study provides a comprehensive analysis of the core molecular networks that are modulated during peripheral axon regrowth after injury.
openaire   +3 more sources