Pure-silk fibroin hydrogel with stable aligned micropattern toward peripheral nerve regeneration
Successful repair of long-distance peripheral nerve injuries remains a challenge in the clinic. Rapid axon growth is a key to accelerate nerve regeneration.
Gu Xinyi+6 more
doaj +1 more source
The Application of Brain Organoids in Assessing Neural Toxicity
The human brain is a complicated and precisely organized organ. Exogenous chemicals, such as pollutants, drugs, and industrial chemicals, may affect the biological processes of the brain or its function and eventually lead to neurological diseases ...
Pan Fan+5 more
doaj +1 more source
The effects of age and ganglioside composition on the rate of motor nerve terminal regeneration following antibody-mediated injury in mice [PDF]
Gangliosides are glycosphingolipids highly enriched in neural plasma membranes, where they mediate a diverse range of functions and can act as targets for auto-antibodies present in human immune-mediated neuropathy sera.
Cunningham, Madeleine E.+4 more
core +1 more source
Rabphilin-3A undergoes phase separation to regulate GluN2A mobility and surface clustering
GluN2A and GluN2B, two predominant Glu2N subunits of NMDARs in hippocampus and cortex, display distinct organization and mobility in the neuronal surface.
Lei Yang+9 more
doaj +1 more source
Wind Noise Reduction with a Diffusion-based Stochastic Regeneration Model [PDF]
In this paper we present a method for single-channel wind noise reduction using our previously proposed diffusion-based stochastic regeneration model combining predictive and generative modelling. We introduce a non-additive speech in noise model to account for the non-linear deformation of the membrane caused by the wind flow and possible clipping. We
arxiv
A Model for Investigating Developmental Eye Repair in Xenopus Laevis [PDF]
Vertebrate eye development is complex and requires early interactions between neuroectoderm and surface ectoderm during embryogenesis. In the African clawed frog, Xenopus laevis, individual eye tissues such as the retina and lens can undergo regeneration.
Kha, Cindy X.+3 more
core +2 more sources
Functional glutamate transporters are expressed in the carotid chemoreceptor
Background The carotid body (CB) plays a critical role in cyclic intermittent hypoxia (CIH)-induced chemosensitivity; however, the underlying mechanism remains uncertain. We have demonstrated the presence of multiple inotropic glutamate receptors (iGluRs)
Chaohong Li+5 more
doaj +1 more source
Background Microglia activation induced by α-synuclein (α-syn) is one of the most important factors in Parkinson’s disease (PD) pathogenesis. However, the molecular mechanisms by which α-syn exerts neuroinflammation and neurotoxicity remain largely ...
Ya-Nan Zhang+5 more
doaj +1 more source
Iron role paradox in nerve degeneration and regeneration [PDF]
Iron accumulates in the neural tissue during peripheral nerve degeneration. Some studies have already been suggested that iron facilitates Wallerian degeneration (WD) events such as Schwann cell de-differentiation. On the other hand, intracellular iron levels remain elevated during nerve regeneration and gradually decrease.
arxiv +1 more source
Robust and Scalable Hyperdimensional Computing With Brain-Like Neural Adaptations [PDF]
The Internet of Things (IoT) has facilitated many applications utilizing edge-based machine learning (ML) methods to analyze locally collected data. Unfortunately, popular ML algorithms often require intensive computations beyond the capabilities of today's IoT devices. Brain-inspired hyperdimensional computing (HDC) has been introduced to address this
arxiv