Using Crosslinked Hyaluronic Acid (HA) and Collagen Scaffolds with Sustained Brain-Derived Neurotrophic Factor (BDNF) Release for Post-SCI Nerve Regeneration [PDF]
Traumatic events resulting in spinal cord injuries (SCIs) often leave people paralyzed or with partial loss of motor function. The physical disabilities arising from traumatic events prevent people from functioning at the same level as pre-injury.
Doshi, Panth
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This study introduces a conductive nerve guidance conduit integrated with wireless electrical stimulation through alternating magnetic fields, which induces currents and creates a supportive microenvironment for nerve regeneration. In vivo studies show that this approach significantly enhanced myelin restoration, gastrocnemius muscle regeneration ...
Shiheng Liu+7 more
wiley +1 more source
Using the Xenopus Developmental Eye Regrowth Stystem to Distinguish the Role of Developmental Versus Regenerative Mechanisms [PDF]
A longstanding challenge in regeneration biology is to understand the role of developmental mechanisms in restoring lost or damaged tissues and organs.
Guerin, Dylan J.+2 more
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Bacteriophages and development of nanomaterials for neural regeneration
Bacteriophages (phages) are viruses that infect bacterial cells and hijack the metabolism of the host cells for replication and amplification of their genetic information. These bacterial viruses are known to be the most numerous life forms on earth. Recent metagenomic analyses have revealed the vast untapped diversity of bacteriophages reinforcing the
Majid Sadeghizadeh, Babak Bakhshinejad
openaire +3 more sources
Bioresorbable and Wireless Rechargeable Implanted Na‐ion Battery for Temporary Medical Devices
An all‐solid‐state bioresorbable Na‐ion battery is developed, composed entirely of bio‐eliminable materials. In vivo and ex vivo tests confirmed harmless disintegration of this implanted battery. Lifetime of the implanted battery can be precisely controlled by adjusting the dissolvable encapsulation layer's thickness.
Vedi Kuyil Azhagan Muniraj+8 more
wiley +1 more source
Multipotent vascular stem cells contribute to neurovascular regeneration of peripheral nerve. [PDF]
BackgroundNeurovascular unit restoration is crucial for nerve regeneration, especially in critical gaps of injured peripheral nerve. Multipotent vascular stem cells (MVSCs) harvested from an adult blood vessel are involved in vascular remodeling; however,
Hsueh, Yuan-Yu+4 more
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Microvesicles as vehicles for tissue regeneration: Changing of the guards [PDF]
Purpose of Review: Microvesicles (MVs) have been recognised as mediators of stem cell function, enabling and guiding their regenerative effects. Recent Findings: MVs constitute one unique size class of extracellular vesicles (EVs) directly shed from ...
Davies, R. Wayne+3 more
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Ultrathin, flexible neural probes are developed with an innovative, biomimetic design incorporating brain tissue‐compatible materials. The material system employs biomolecule‐based encapsulation agents to mitigate inflammatory responses, as demonstrated through comprehensive in vitro and in vivo studies.
Jeonghwa Jeong+7 more
wiley +1 more source
Extracellular vesicles, ageing, and therapeutic interventions [PDF]
A more comprehensive understanding of the human ageing process is required to help mitigate the increasing burden of age-related morbidities in a rapidly growing global demographic of elderly individuals.
Neytchev, Ognian+3 more
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Bioorthogonal Engineering of Cellular Microenvironments Using Isonitrile Ligations
Highly selective chemistries are required for fabrication and post‐cross–linking modification of cell‐encapsulating hydrogels used in tissue engineering applications. Isonitrile ligation reactions represent a promising class of bioorthogonal chemistries for engineering hydrogel‐based cellular microenvironments. Isonitrile‐based hydrogels are stable and
Ping Zhou+2 more
wiley +1 more source