Results 1 to 10 of about 268,028 (214)

Prognostic role and tumor-suppressive effects of CADM family members and the potential molecular mechanisms of CADM1 in neuroblastoma [PDF]

Discover Oncology
Background The exact role of cell adhesion molecule (CADM) family members in neuroblastoma is still being explored. Here we uncovered the survival association and the possible mechanisms of CADMs in neuroblastoma through comprehensive bioinformatic ...
Yu Wang, Lingling Zheng, Jun Liu, Mingyu Zhang, Ying Kan, Wei Wang, Jigang Yang   +6 more
doaj   +2 more sources

Neuroblastoma patient outcomes, tumor differentiation, and ERK activation are correlated with expression levels of the ubiquitin ligase UBE4B. [PDF]

, 2016
BackgroundUBE4B is an E3/E4 ubiquitin ligase whose gene is located in chromosome 1p36.22. We analyzed the associations of UBE4B gene and protein expression with neuroblastoma patient outcomes and with tumor prognostic features and histology.MethodsWe ...
Bean, Andrew J, Guo, Rong Jun, Hollingsworth, Emporia Faith, Indiviglio, Sandra, Ittmann, Michael, Liu, Yin, Lopez-Terrada, Dolores, Major, Angela M, Mo, Qianxing, Whittle, Sarah B, Woodfield, Sarah E, Zage, Peter E   +11 more
core   +8 more sources

MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis

Nature Cancer, 2022
Aberrant expression of MYC transcription factor family members predicts poor clinical outcome in many human cancers. Oncogenic MYC profoundly alters metabolism and mediates an antioxidant response to maintain redox balance. Here we show that MYCN induces
H. Alborzinia, Andrés F. Flórez, Sina Kreth, L. Brückner, Umut Yildiz, Moritz Gartlgruber, Dorett I Odoni, Gernot Poschet, Karolina Garbowicz, Chunxuan Shao, C. Klein, Jasmin Meier, Petra Zeisberger, Michal Nadler-Holly, Matthias Ziehm, F. Paul, J. Burhenne, E. Bell, Marjan Shaikhkarami, Roberto Würth, Sabine A. Stainczyk, Elisa M Wecht, Jochen Kreth, M. Büttner, Naveed Ishaque, M. Schlesner, B. Nicke, Carlo Stresemann, Maria Llamazares-Prada, J. Reiling, M. Fischer, I. Amit, M. Selbach, C. Herrmann, S. Wölfl, K. Henrich, T. Höfer, A. Trumpp, F. Westermann   +38 more
semanticscholar   +1 more source

Why Is Aneuploidy Associated with Favorable Outcome in Neuroblastoma?

Biomolecules, 2021
Neuroblastoma is a pediatric cancer, onset with localized as well as metastatic disease. Localized tumors usually show a high content of aneuploid cells.
Gian Paolo Tonini
doaj   +1 more source

Revised Neuroblastoma Risk Classification System: A Report From the Children's Oncology Group

Journal of Clinical Oncology, 2021
PURPOSE Treatment planning for children with neuroblastoma requires accurate assessment of prognosis. The most recent Children's Oncology Group (COG) risk classification system used tumor stage as defined by the International Neuroblastoma Staging System.
M. Irwin, A. Naranjo, Fan F. Zhang, S. Cohn, W. London, J. Gastier-Foster, N. Ramirez, R. Pfau, S. Reshmi, Elizabeth Wagner, J. Nuchtern, S. Asgharzadeh, H. Shimada, J. Maris, R. Bagatell, Julie R. Park, M. Hogarty   +16 more
semanticscholar   +1 more source

Transition to a mesenchymal state in neuroblastoma confers resistance to anti-GD2 antibody via reduced expression of ST8SIA1

Nature Cancer, 2022
Immunotherapy with anti-GD2 antibodies has advanced the treatment of children with high-risk neuroblastoma, but nearly half of patients relapse, and little is known about mechanisms of resistance to anti-GD2 therapy.
Nathaniel W. Mabe, Min Huang, G. N. Dalton, G. Alexe, Daniel A. Schaefer, Anna C. Geraghty, A. Robichaud, A. Conway, D. Khalid, M. Mader, J. Belk, K. Ross, Michal Sheffer, Miles H. Linde, Nghi Ly, Winnie Yao, M. Rotiroti, Benjamin A. H. Smith, Marius Wernig, C. Bertozzi, Michelle Monje, C. Mitsiades, R. Majeti, Ansuman T. Satpathy, K. Stegmaier, R. Majzner   +25 more
semanticscholar   +1 more source

Indisulam targets RNA splicing and metabolism to serve as a therapeutic strategy for high-risk neuroblastoma

Nature Communications, 2022
Neuroblastoma is the most common paediatric solid tumour and prognosis remains poor for high-risk cases despite the use of multimodal treatment. Analysis of public drug sensitivity data showed neuroblastoma lines to be sensitive to indisulam, a molecular
A. Nijhuis, Arti Sikka, Orli Yogev, Lili Herendi, Cristina Balcells, Yurui Ma, E. Poon, C. Eckold, Gabriel N. Valbuena, Yuewei Xu, Yusong Liu, B. M. da Costa, Michael Gruet, Chiharu Wickremesinghe, A. Benito, Holger B. Kramer, Alex Montoya, D. Carling, E. Want, Y. Jamin, L. Chesler, Hector C. Keun   +21 more
semanticscholar   +1 more source

Neuroblastoma Heterogeneity, Plasticity, and Emerging Therapies

Current Oncology Reports, 2022
The evolving information of the initiation, tumor cell heterogeneity, and plasticity of childhood neuroblastoma has opened up new perspectives for developing therapies based on detailed knowledge of the disease.
K. Lundberg, D. Treis, J. Johnsen
semanticscholar   +1 more source

Inhibition of PI3 kinase isoform p110α suppresses neuroblastoma growth and induces the reduction of Anaplastic Lymphoma Kinase

Cell & Bioscience, 2022
Background In neuroblastoma, hyperactivation of the PI3K signaling pathway has been correlated with aggressive neuroblastomas, suggesting PI3Ks as promising targets for the treatment of neuroblastoma.
Yue Guo, Donghao Guo, Shaoting Zhang, Yuan Zhang, Xiaoyan He, Xiaohua Jiang, Andrew Man-Lok Chan, Lin Zou, Jianmin Sun, Hui Zhao   +9 more
doaj   +1 more source

Autophagic flux inhibition enhances cytotoxicity of the receptor tyrosine kinase inhibitor ponatinib

Journal of Experimental & Clinical Cancer Research, 2020
Background Despite reported advances, acquired resistance to tyrosine kinase inhibitors still represents a serious problem in successful cancer treatment.
Diana Corallo, Fabio Pastorino, Marcella Pantile, Elena Mariotto, Federico Caicci, Giampietro Viola, Mirco Ponzoni, Gian Paolo Tonini, Sanja Aveic   +8 more
doaj   +1 more source