Results 31 to 40 of about 11,252 (195)

Molecular Modeling of Neurokinin B and Neurokinin-3 Receptor Complex [PDF]

open access: bronzeBiophysical Journal, 2011
The Neurokinin-3 (NK-3) receptor is a member of the Rhodopsin family of G-protein coupled receptors. NK-3 receptor has been regarded as an important drug target due to diverse physiological functions and its possible role in the pathophysiology of psychiatric disorders, including schizophrenia.
Anjali Ganjiwale   +2 more
openalex   +2 more sources

Basal Serum Neurokinin B Levels in Differentiating Idiopathic Central Precocious Puberty from Premature Thelarche. [PDF]

open access: goldJ Clin Res Pediatr Endocrinol, 2017
Parlak M   +5 more
europepmc   +2 more sources

Harnessing the Anti-Nociceptive Potential of NK2 and NK3 Ligands in the Design of New Multifunctional μ/δ-Opioid Agonist–Neurokinin Antagonist Peptidomimetics

open access: yesMolecules, 2021
Opioid agonists are well-established analgesics, widely prescribed for acute but also chronic pain. However, their efficiency comes with the price of drastically impacting side effects that are inherently linked to their prolonged use.
Charlène Gadais   +5 more
doaj   +1 more source

Opioidergic pathways and kisspeptin in the regulation of female reproduction in mammals

open access: yesFrontiers in Neuroscience, 2022
Endogenous opioid peptides have attracted attention as critical neuropeptides in the central mechanism regulating female reproduction ever since the discovery that arcuate dynorphin neurons that coexpress kisspeptin and neurokinin B (NKB), which are also
Yoshihisa Uenoyama   +4 more
doaj   +1 more source

Mechanism of kisspeptin neuron synchronization for pulsatile hormone secretion in male mice

open access: yesCell Reports, 2023
Summary: The mechanism by which arcuate nucleus kisspeptin (ARNKISS) neurons co-expressing glutamate, neurokinin B, and dynorphin intermittently synchronize their activity to generate pulsatile hormone secretion remains unknown.
Su Young Han   +7 more
doaj   +1 more source

Neurokinin B administration induces hot flushes in women. [PDF]

open access: yesSci Rep, 2015
AbstractNeurokinin B (NKB) is a hypothalamic neuropeptide binding preferentially to the neurokinin 3 receptor. Expression of the gene encoding NKB is elevated in postmenopausal women. Furthermore, rodent studies suggest that NKB signalling may mediate menopausal hot flushes.
Jayasena CN   +14 more
europepmc   +6 more sources

Tachykinin neuropeptides in cerebellar granule neurons: an immunocytochemical study

open access: yesEuropean Journal of Histochemistry, 2009
We previously demonstrated that exogenously administered neurokinin A and neurokinin B, but not substance P, increased the sensitivity of cultured cerebellar granule neurons (CGNs) to glutamate.
C Barbato, MT Ciotti
doaj   +1 more source

Possible causes and treatment strategies for the estrus and ovulation disorders in dairy cows

open access: yesThe Journal of Reproduction and Development, 2022
The reproductive performance of dairy cows has declined, along with an increase in their milk yield. First-service conception rates in lactating dairy cows are often lower than 50%.
Natsumi ENDO
doaj   +1 more source

The possible link between the elevated serum levels of neurokinin A and anti-ribosomal P protein antibodies in children with autism

open access: yesJournal of Neuroinflammation, 2011
Background Neurogenic inflammation is orchestrated by a large number of neuropeptides. Tachykinins (substance P, neurokinin A and neurokinin B) are pro-inflammatory neuropeptides that may play an important role in some autoimmune neuroinflammatory ...
Mostafa Gehan A, AL-Ayadhi Laila Y
doaj   +1 more source

Neuropeptide modulation of lymphatic smooth muscle tone in the canine forelimb

open access: yesMediators of Inflammation, 1992
Neurokinin A and B are putative inflammatory mediators. We assessed their ability to alter prenodal lymphatic resistance. Intralymphatic neurokinin A (3.0 × 10−6, 3.0 × 10−5 and 3.0 × 10−4 mol l−1) significantly constricted lymphatics at the two highest ...
David E. Dobbins
doaj   +1 more source

Home - About - Disclaimer - Privacy