Results 11 to 20 of about 188,649 (338)

Exploratory drive, fear, and anxiety are dissociable and independent components in foraging mice

Translational Psychiatry, 2021
Anxiety-like behavior of rodents is frequently accompanied by reduced exploration. Here, we identify dissociable components of anxiety, fear, and exploratory drive of sated and foraging mice.
Daniel E. Heinz, Vivian A. Schöttle, Paulina Nemcova, Florian P. Binder, Tim Ebert, Katharina Domschke, Carsten T. Wotjak   +6 more
doaj   +1 more source

Activation of NLRP3 Is Required for a Functional and Beneficial Microglia Response after Brain Trauma

Pharmaceutics, 2022
Despite the numerous research studies on traumatic brain injury (TBI), many physiopathologic mechanisms remain unknown. TBI is a complex process, in which neuroinflammation and glial cells play an important role in exerting a functional immune and damage-
Ana Belen Lopez-Rodriguez, Céline Decouty-Perez, Victor Farré-Alins, Alejandra Palomino-Antolín, Paloma Narros-Fernández, Javier Egea   +5 more
doaj   +1 more source

Lobe X of the Cerebellum: A Natural Neuro-Resistant Region

Anatomia, 2023
The cerebellum is an encephalic region classically known for its central role in the control of movement, although recent research has revealed its involvement in other cognitive and affective tasks. Several different pathologies are known to affect this
Carlos Hernández-Pérez, Eduardo Weruaga, David Díaz   +2 more
doaj   +1 more source

Intranasal Administration of PACAP Is an Efficient Delivery Route to Reduce Infarct Volume and Promote Functional Recovery After Transient and Permanent Middle Cerebral Artery Occlusion

Frontiers in Endocrinology, 2021
Intranasal (IN) administration appears to be a suitable route for clinical use as it allows direct delivery of bioactive molecules to the central nervous system, reducing systemic exposure and sides effects.
Asma Cherait, Asma Cherait, Asma Cherait, Julie Maucotel, Julie Maucotel, Benjamin Lefranc, Benjamin Lefranc, Jérôme Leprince, Jérôme Leprince, David Vaudry, David Vaudry   +10 more
doaj   +1 more source

Secretagogin expression in the mouse olfactory bulb under sensory impairments

Scientific Reports, 2020
The interneurons of the olfactory bulb (OB) are characterized by the expression of different calcium-binding proteins, whose specific functions are not fully understood.
L. Pérez-Revuelta, P. G. Téllez de Meneses, M. López, J. G. Briñón, E. Weruaga, D. Díaz, J. R. Alonso   +6 more
doaj   +1 more source

Myo-Inositol Levels in the Dorsal Hippocampus Serve as Glial Prognostic Marker of Mild Cognitive Impairment in Mice

Frontiers in Aging Neuroscience, 2021
Dementia is a devastating age-related disorder. Its therapy would largely benefit from the identification of susceptible subjects at early, prodromal stages of the disease. To search for such prognostic markers of cognitive impairment, we studied spatial
Tim Ebert, Tim Ebert, Daniel E. Heinz, Daniel E. Heinz, Suellen Almeida-Corrêa, Renata Cruz, Frederik Dethloff, Tibor Stark, Tibor Stark, Tibor Stark, Thomas Bajaj, Oriana M. Maurel, Fabiola M. Ribeiro, Silvio Calcagnini, Kathrin Hafner, Nils C. Gassen, Nils C. Gassen, Christoph W. Turck, Benoit Boulat, Michael Czisch, Carsten T. Wotjak, Carsten T. Wotjak   +21 more
doaj   +1 more source

Whole-brain tracking of cocaine and sugar rewards processing

Translational Psychiatry, 2023
Natural rewards, such as food, and sex are appetitive stimuli available for animals in their natural environment. Similarly, addictive rewards such as drugs of abuse possess strong, positive valence, but their action relies on their pharmacological ...
Łukasz Bijoch, Joanna Klos, Monika Pawłowska, Justyna Wiśniewska, Diana Legutko, Urszula Szachowicz, Leszek Kaczmarek, Anna Beroun   +7 more
doaj   +1 more source

A simplified microwave-based motion detector for home cage activity monitoring in mice

Journal of Biological Engineering, 2017
Background Locomotor activity of rodents is an important readout to assess well-being and physical health, and is pivotal for behavioral phenotyping.
Andreas Genewsky, Daniel E. Heinz, Paul M. Kaplick, Kasyoka Kilonzo, Carsten T. Wotjak   +4 more
doaj   +1 more source

A longitudinal, randomized experimental pilot study to investigate the effects of airborne infrasound on human mental health, cognition, and brain structure

Scientific Reports, 2021
Airborne infrasound (IS; emitted by e.g., large machinery, wind farms) is ubiquitous in technologized environments. Health hazards are controversially discussed at present.
L. Ascone, C. Kling, J. Wieczorek, C. Koch, S. Kühn   +4 more
doaj   +1 more source

A longitudinal, randomized experimental pilot study to investigate the effects of airborne ultrasound on human mental health, cognition, and brain structure

Scientific Reports, 2021
Ultrasound-(US) emitting sources are highly present in modern human environments (e.g., movement sensors, electric transformers). US affecting humans or even posing a health hazard remains understudied. Hence, ultrasonic (22.4 kHz) vs.
L. Ascone, C. Kling, J. Wieczorek, C. Koch, S. Kühn   +4 more
doaj   +1 more source