Results 51 to 60 of about 345,454 (237)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Astroglial CD38 impairs hippocampal synaptic plasticity after global cerebral ischemia

Frontiers in Stroke
Cardiac arrest-induced global cerebral ischemia (GCI) results in profound cognitive impairment in survivors. Our prior work demonstrated persistent disruption of long-term potentiation (LTP) in hippocampal CA1 neurons, correlating with learning and ...
Amelia M. Burch, Ami Haas, James E. Orfila, Erika Tiemeier, Cassidy De Anda Gamboa, Nicholas Chalmers, Nidia Quillinan, Paco S. Herson   +7 more
doaj   +1 more source

Stimulation of the Nigrotectal Pathway at the Level of the Superior Colliculus Reduces Threat Recognition and Causes a Shift From Avoidance to Approach Behavior

Frontiers in Neural Circuits, 2018
Defensive behavioral responses are essential for survival in threating situations. The superior colliculus (SC) has been implicated in the generation of defensive behaviors elicited by visual, tactile and auditory stimuli.
Rafael C. Almada, Rafael C. Almada, Rafael C. Almada, Andreas J. Genewsky, Daniel E. Heinz, Daniel E. Heinz, Paul M. Kaplick, Norberto C. Coimbra, Norberto C. Coimbra, Norberto C. Coimbra, Carsten T. Wotjak   +10 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Resting state network changes induced by experimental inaudible infrasound exposure and associations with self-reported noise sensitivity and annoyance

Scientific Reports
The effects of prolonged infrasound (IS) exposure on brain function and behavior are largely unknown, with only one prior study investigating functional connectivity (FC) changes.
Caroline Garcia Forlim, Leonie Ascone, Christian Koch, Simone Kühn   +3 more
doaj   +1 more source

Image informatics strategies for deciphering neuronal network connectivity [PDF]

, 2016
Brain function relies on an intricate network of highly dynamic neuronal connections that rewires dramatically under the impulse of various external cues and pathological conditions.
A Dani, A Rodriguez, A Rodriguez, A Rodriguez, B Deleglise, B Zhang, BA Wilt, C Sala, CG Dotti, D Cai, D Gerlich, D Popova, D Prodanov, D Smetters, DA Dombeck, DA Dombeck, DW Godwin, E Cohen, E Fluhler, E Meijering, E Meijering, E Meijering, EW Dent, F Cornelissen, F Janoos, G Pani, GG Gurkoff, GP Feng, GS Belinsky, H Bading, H Chen, H Peng, H Peng, HH Piao, IR Wickersham, IY Koh, J Cheng, J Fan, J Fan, J Lammerding, J Liu, J Livet, JA Harrill, JI Luebke, JL Chen, JM Nussbaum, K Chung, K Deisseroth, K Imamura, K Takahashi, KA Al-Kofahi, KD Micheva, KE Binley, KM Brown, KO Lai, KR Kay, L Bretzner, L Feng, L Grosenick, L Jin, L Jin, LD Costa, M Meijer, M Naujock, M Papa, M Pickering, M Pool, M Wittmann, ML Narro, MS Siegel, N Heck, O Sirenko, P Chothani, P Maiti, P Penzes, P Roqué, P Sarder, P Shi, P Verstraelen, Q Li, Q Li, R Nair, R Parekh, RA McKinney, RM Paredes, S Cho, S Schmitt, SK Schmitz, SL Wearne, SY Ho, SY Kim, T Nemoto, T Zhao, TL Fletcher, VA Alvarez, W Bai, WH Vos De, Y Al-Kofahi, Y Zhang, YC Lin   +99 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Bone Marrow Contributes Simultaneously to Different Neural Types in the Central Nervous System through Different Mechanisms of Plasticity

Cell Transplantation, 2011
Many studies have reported the contribution of bone marrow-derived cells (BMDC) to the CNS, raising the possibility of using them as a new source to repair damaged brain tissue or restore neuronal function.
Javier S. Recio, Manuel Álvarez-Dolado, David Díaz, Fernando C. Baltanás, Marina Piquer-Gil, José R. Alonso, Eduardo Weruaga Ph.D.   +6 more
doaj   +1 more source

The Effects of the Circadian Rhythm on Nicotine-induced Neuronal Plasticity [PDF]

, 2011
Nicotine is a widely popular addictive drug that alters neural circuits in the brain. The resulting neuronal plasticity is varied by the inherent circadian rhythm.
Muruganantham, Kavitha
core   +2 more sources