Results 51 to 60 of about 866,630 (334)

CCT4 promotes tunneling nanotube formation

FEBS Letters, EarlyView.
Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto, Akiko Asada, Taro Saito, Kanae Ando   +3 more
wiley   +1 more source

Foldscope as an Innovative Teaching Tool

Education Sciences, 2022
This study deals with the descriptive analysis of the opinion of a pilot group of students at the University of Salamanca about the use of an innovative origami microscope: the Foldscope.
Carlos Hernández-Pérez, María Nieto-Sobrino   +1 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Relevance of Cognition and Emotion for Patient-Reported Quality of Life After Stroke in Working Age: An Observational Cohort Study

Frontiers in Neurology, 2022
BackgroundPatient-reported quality of life (QoL) may help to capture sequela of stroke more comprehensively. We aimed to investigate QoL in working age persons with ischemic stroke regarding impaired domains and identify factors associated with better ...
Daniela Pinter, Daniela Pinter, Simon Fandler-Höfler, Viktoria Fruhwirth, Viktoria Fruhwirth, Lisa Berger, Lisa Berger, Gerhard Bachmaier, Susanna Horner, Sebastian Eppinger, Markus Kneihsl, Christian Enzinger, Christian Enzinger, Christian Enzinger, Thomas Gattringer, Thomas Gattringer   +15 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Evaluation of a Newly Developed Smartphone App for Risk Factor Management in Young Patients With Ischemic Stroke: A Pilot Study

Frontiers in Neurology, 2022
Background: Efficient treatment of modifiable vascular risk factors decreases reoccurrence of ischemic stroke, which is of uttermost importance in younger patients.
Viktoria Fruhwirth, Viktoria Fruhwirth, Lisa Berger, Lisa Berger, Thomas Gattringer, Thomas Gattringer, Simon Fandler-Höfler, Markus Kneihsl, Andreas Schwerdtfeger, Elisabeth Margarete Weiss, Christian Enzinger, Christian Enzinger, Christian Enzinger, Daniela Pinter, Daniela Pinter   +14 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Astroglial CD38 impairs hippocampal synaptic plasticity after global cerebral ischemia

Frontiers in Stroke
Cardiac arrest-induced global cerebral ischemia (GCI) results in profound cognitive impairment in survivors. Our prior work demonstrated persistent disruption of long-term potentiation (LTP) in hippocampal CA1 neurons, correlating with learning and ...
Amelia M. Burch, Ami Haas, James E. Orfila, Erika Tiemeier, Cassidy De Anda Gamboa, Nicholas Chalmers, Nidia Quillinan, Paco S. Herson   +7 more
doaj   +1 more source

Stimulation of the Nigrotectal Pathway at the Level of the Superior Colliculus Reduces Threat Recognition and Causes a Shift From Avoidance to Approach Behavior

Frontiers in Neural Circuits, 2018
Defensive behavioral responses are essential for survival in threating situations. The superior colliculus (SC) has been implicated in the generation of defensive behaviors elicited by visual, tactile and auditory stimuli.
Rafael C. Almada, Rafael C. Almada, Rafael C. Almada, Andreas J. Genewsky, Daniel E. Heinz, Daniel E. Heinz, Paul M. Kaplick, Norberto C. Coimbra, Norberto C. Coimbra, Norberto C. Coimbra, Carsten T. Wotjak   +10 more
doaj   +1 more source