Results 61 to 70 of about 866,630 (334)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Scientific ReportsThe effects of prolonged infrasound (IS) exposure on brain function and behavior are largely unknown, with only one prior study investigating functional connectivity (FC) changes.
Caroline Garcia Forlim +3 more
doaj +1 more source
Regulation of Neuronal Differentiation, Function, and Plasticity by Alternative Splicing.
Annual Review of Cell and Developmental Biology, 2018 Posttranscriptional mechanisms provide powerful means to expand the coding power of genomes. In nervous systems, alternative splicing has emerged as a fundamental mechanism not only for the diversification of protein isoforms but also for the ...
Elisabetta Furlanis, P. Scheiffele
semanticscholar +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Cell Transplantation, 2011 Many studies have reported the contribution of bone marrow-derived cells (BMDC) to the CNS, raising the possibility of using them as a new source to repair damaged brain tissue or restore neuronal function.
Javier S. Recio +6 more
doaj +1 more source
Neuronal Plasticity in the Entorhinal Cortex
Neural Plasticity, 2008 The entorhinal cortex (EC) is a unique and fascinating structure, constituting a highly parallel interface between phylogenetically old cortex (hippocampus) and higher neocortical areas. The literature related to the EC has increased dramatically in the past 30 years. A simple PubMed search for EC lists around 20–40 articles per year in the early 1980s.
C. Andrew Chapman +2 more
openaire +3 more sources
FEBS Open Bio, EarlyView.Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu +6 more
wiley +1 more source
Palatable Hyper-Caloric Foods Impact on Neuronal Plasticity
Frontiers in Behavioral Neuroscience, 2017 Neural plasticity is an intrinsic and essential characteristic of the nervous system that allows animals “self-tuning” to adapt to their environment over their lifetime.
Jean-Pascal Morín +6 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado +4 more
wiley +1 more source
Cell Transplantation, 2012 Bone marrow-derived cells have different plastic properties, especially regarding cell fusion, which increases with time and is prompted by tissue injury.
David Díaz +3 more
doaj +1 more source