Results 61 to 70 of about 189,538 (338)
Local dendritic balance enables learning of efficient representations in networks of spiking neurons [PDF]
, 2020 How can neural networks learn to efficiently represent complex and high-dimensional inputs via local plasticity mechanisms? Classical models of representation learning assume that input weights are learned via pairwise Hebbian-like plasticity. Here, we show that pairwise Hebbian-like plasticity only works under unrealistic requirements on neural ...
arxiv +1 more source
Advanced Biology, EarlyView.Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi +4 more
wiley +1 more source
Why do mice squeak? Toward a better understanding of defensive vocalization
iScience, 2022 Summary: Although mice mostly communicate in the ultrasonic range, they also emit audible calls. We demonstrate that mice selectively bred for high anxiety-related behavior (HAB) have a high disposition for emitting sonic calls when caught by the tail ...
Julia Ruat +7 more
doaj
Advanced Engineering Materials, EarlyView.The study presents an efficient simulation approach for the polymer laser powder bed fusion process polymers process, validated with polyamide 12, polyamide 6, and polyetherketoneketone. It shows that inter layer time affects part density, with 90s yielding dense parts.
Claas Bierwisch +4 more
wiley +1 more source
eLife, 2017 The amyloid precursor protein (APP) harbors physiological roles at synapses and is central to Alzheimer’s disease (AD) pathogenesis. Evidence suggests that APP intracellular domain (AICD) could regulate synapse function, but the underlying molecular ...
Paula A Pousinha +11 more
doaj +1 more source
Neural Plasticity, 2021 Hippocampal cell death and cognitive dysfunction are common following global cerebral ischemia across all ages, including children. Most research has focused on preventing neuronal death.
Robert M. Dietz +7 more
doaj +1 more source
A Case‐Based Reasoning Approach to Model Manufacturing Constraints for Impact Extrusion
Advanced Engineering Materials, EarlyView.A hybrid modeling approach is presented that combines constraint‐based process modeling and case‐based reasoning. The model formalizes manufacturing constraints and integrates simulation data to model complex manufacturing processes. The approach supports manufacturability analysis during product design through an adaptive modeling environment.
Kevin Herrmann +5 more
wiley +1 more source
Cell Type-specific Metabolic Labeling of Proteins with Azidonorleucine in Drosophila
Bio-Protocol, 2017 Advanced mass spectrometry technology has pushed proteomic analyses to the forefront of biological and biomedical research. Limitations of proteomic approaches now often remain with sample preparations rather than with the sensitivity of protein ...
Ines Erdmann +9 more
doaj +1 more source
Advanced Engineering Materials, EarlyView.In this study, the mechanical response of Y‐shaped core sandwich beams under compressive loading is investigated, using deep feed‐forward neural networks (DFNNs) for predictive modeling. The DFNN model accurately captures stress–strain behavior, influenced by design parameters and loading rates.
Ali Khalvandi +4 more
wiley +1 more source
Strategies for the Identification of Bioactive Neuropeptides in Vertebrates
Frontiers in Neuroscience, 2019 Neuropeptides exert essential functions in animal physiology by controlling e.g., reproduction, development, growth, energy homeostasis, cardiovascular activity and stress response.
Auriane Corbière +10 more
doaj +1 more source