Results 1 to 10 of about 16,162 (178)

Migraine and cluster headache show impaired neurosteroids patterns [PDF]

The Journal of Headache and Pain, 2019
Background Perturbation of neuronal excitability contributes to migraine. Neurosteroids modulate the activity of γ-aminobutyric acid A and N-methyl-d-aspartate receptors, and might be involved in the pathogenesis of migraine.
Angela Koverech, Claudia Cicione, Luana Lionetto, Marta Maestri, Francesco Passariello, Elisabetta Sabbatini, Matilde Capi, Cristiano Maria De Marco, Martina Guglielmetti, Andrea Negro, Luisa Di Menna, Maurizio Simmaco, Ferdinando Nicoletti, Paolo Martelletti   +13 more
doaj   +4 more sources

Structural insights into opposing actions of neurosteroids on GABAA receptors

Nature Communications, 2023
γ-Aminobutyric acid type A (GABAA) receptors mediate fast inhibitory signaling in the brain and are targets of numerous drugs and endogenous neurosteroids.
Dagimhiwat H. Legesse, Chen Fan, Jinfeng Teng, Yuxuan Zhuang, Rebecca J. Howard, Colleen M. Noviello, Erik Lindahl, Ryan E. Hibbs   +7 more
doaj   +2 more sources

Human Microglia Synthesize Neurosteroids to Cope with Rotenone-Induced Oxidative Stress

Antioxidants, 2023
We obtained evidence that mouse BV2 microglia synthesize neurosteroids dynamically to modify neurosteroid levels in response to oxidative damage caused by rotenone.
Chiara Lucchi, Alessandro Codeluppi, Monica Filaferro, Giovanni Vitale, Cecilia Rustichelli, Rossella Avallone, Jessica Mandrioli, Giuseppe Biagini   +7 more
doaj   +2 more sources

Rapid Estrogenic and Androgenic Neurosteroids Effects in the Induction of Long-Term Synaptic Changes: Implication for Early Memory Formation

Frontiers in Neuroscience, 2020
Mounting experimental evidence demonstrate that sex neuroactive steroids (neurosteroids) are essential for memory formation. Neurosteroids have a profound impact on the function and structure of neural circuits and their local synthesis is necessary for ...
Alessandro Tozzi, Laura Bellingacci, Vito Enrico Pettorossi   +2 more
doaj   +2 more sources

Genomic and Non-genomic Action of Neurosteroids in the Peripheral Nervous System

Frontiers in Neuroscience, 2020
Since the former evidence of biologic actions of neurosteroids in the central nervous system, also the peripheral nervous system (PNS) was reported as a structure affected by these substances.
Alessandra Colciago, Veronica Bonalume, Valentina Melfi, Valerio Magnaghi   +3 more
doaj   +2 more sources

Neurosteroids: a lifelong impact on brain health [PDF]

Frontiers in Behavioral Neuroscience
Neurosteroids are critical regulators of brain function, exerting profound effects on neurodevelopment, emotional regulation, cognition, and resilience to stress across the lifespan.
Najah L. Walton, Jamie L. Maguire
doaj   +2 more sources

Neurosteroids in pain management: A new perspective on an old player [PDF]

Frontiers in Pharmacology, 2018
Since the discovery of the nervous system’s ability to produce steroid hormones, numerous studies have demonstrated their importance in modulating neuronal excitability.
Covey, Douglas F, Jevtovic-Todorovic, Vesna, Joksimovic, Sonja L, Todorovic, Slobodan M   +3 more
core   +3 more sources

Structural modifications to pregnane neurosteroids alter inhibition of LPS/Lipid A binding at the MD-2 activation site within the TLR4 signaling complex [PDF]

Frontiers in Immunology
Neurosteroids have emerged as promising candidates for treatment for neuroinflammatory diseases, distinct from their classical GABAergic effects. We previously demonstrated that 3α,5α-THP inhibits binding of the Lipid A moiety of lipopolysaccharide to ...
Alejandro G. Lopez, Alejandro G. Lopez, Venkat R. Chirasani, Venkat R. Chirasani, Irina Balan, Irina Balan, Irina Balan, A. Leslie Morrow, A. Leslie Morrow, A. Leslie Morrow   +9 more
doaj   +2 more sources

Functional Food Nutrients, Redox Resilience Signaling and Neurosteroids for Brain Health. [PDF]

Int J Mol Sci
The interplay between functional food nutrients and neurosteroids has garnered significant attention for its potential to enhance stress resilience in health and/or disease.
Scuto M, Majzúnová M, Torcitto G, Antonuzzo S, Rampulla F, Di Fatta E, Trovato Salinaro A.   +6 more
europepmc   +2 more sources

Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond

Neurobiology of Stress, 2019
The recent FDA approval of the neurosteroid, brexanolone (allopregnanolone), as a treatment for women with postpartum depression, and successful trials of a related neuroactive steroid, SGE-217, for men and women with major depressive disorder offer the ...
Charles F. Zorumski, Steven M. Paul, Douglas F. Covey, Steven Mennerick   +3 more
doaj   +2 more sources