Results 101 to 110 of about 16,231 (234)

Nongenomic effects of neurosteroids

Gynecological Endocrinology, 1998
This review summarizes the current knowledge about the synthesis, the mechanism of action, and the effects of neurosteroids in the central nervous system. Particular attention is paid to the nongenomic actions of neurosteroids, which are discussed in relation to their clinical relevance for physiological and pathological states.
REVELLI, Alberto, TESARIK J., MASSOBRIO, Marco   +2 more
openaire   +3 more sources

Maternal Milk Allopregnanolone May Buffer Negative Associations Between Maternal Postpartum Psychological Distress and Infant Regulatory Capacity

Developmental Psychobiology, Volume 68, Issue 2, March 2026.
ABSTRACT Maternal psychological distress during pregnancy and the early postpartum period is a risk factor for dysregulated affective and regulatory function in young infants. Animal models suggest that perinatal stress may alter offspring development via allopregnanolone (ALLO) exposure.
Denise M. Werchan, Bradley Susskind, Rebecca Carpio, Brittany R. Howell, Natalie H. Brito, Moriah E. Thomason   +5 more
wiley   +1 more source

Dehydroepiandrosterone sulfate (DHEAS) is neuroprotective when administered either before or after injury in a focal cortical cold lesion model [PDF]

, 2006
Dehydroepiandrosterone and its sulfate (DHEAS) are sex hormone precursors that exert marked neurotrophic and/or neuroprotective activity in the central nervous system.
Dobszay B., Gábor, Farkas, Tamás, Juhász-Vedres, Gabriella, Kis, Zsolt, Párducz, Árpád, Rákos, Gabriella, Rózsa, Éva, Toldi, József, Wölfling, János   +8 more
core  

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, Volume 12, Issue 1, Page 96-122, Spring 2026.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source

Metabolic profiling of human plasma and urine in chronic kidney disease by hydrophilic interaction liquid chromatography coupled with time-of-flight mass spectrometry : a pilot study [PDF]

, 2017
A typical characteristic of chronic kidney disease (CKD) is the progressive loss in renal function over a period of months or years with the concomitant accumulation of uremic retention solutes in the body.
Boelaert, Jente, Glorieux, Griet, Lynen, Frederic, Neirynck, Nathalie, Schepers, Eva, Vanholder, Raymond   +5 more
core   +1 more source

Neurosteroids in Adult Hippocampus of Male and Female Rodents: Biosynthesis and Actions of Sex Steroids

Frontiers in Endocrinology, 2018
The brain is not only the target of steroid hormones but also is able to locally synthesize steroids de novo. Evidence of the local production of steroids in the brain has been accumulating in various vertebrates, including teleost fish, amphibia, birds,
Y. Hojo, S. Kawato
semanticscholar   +1 more source

Safety and efficacy of zuranolone in Japanese adults with major depressive disorder: An open‐label, repeated‐treatment part of a Phase 3 clinical trial

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 1, March 2026.
Abstract Aim To evaluate the safety and tolerability of repeating 14‐day treatment with zuranolone (30 mg) followed by a 6‐week follow‐up period (one treatment cycle) for a maximum of six treatment cycles in Japanese participants with major depressive disorder. Methods This multicenter Phase 3 study was conducted in two parts (70 sites; Japan).
Masaki Kato, Kazuyuki Nakagome, Takamichi Baba, Takuhiro Sonoyama, Hiroki Fukuju, Ryosuke Shimizu, Juan Carlos Gomez, Tomoko Motomiya, Takeshi Inoue   +8 more
wiley   +1 more source

Analysis of depressive symptom trajectory patterns with zuranolone: Time‐series clustering of Japanese Phase 2 and Phase 3 trial data

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 1, March 2026.
In this pooled analysis of Phase 2/3 trials in Japanese adults with major depressive disorder (MDD), we aimed to characterize depressive symptom trajectories following zuranolone 30 mg administration. Dynamic Time Warping–based k‐means clustering identified four distinct symptom trajectories.
Masaki Kato, Takamichi Baba, Saki Nakano, Yuto Kashiwagi, Tomoko Motomiya, Nakao Iwata   +5 more
wiley   +1 more source

7alpha-Hydroxypregnenolone, a new key regulator of locomotor activity of vertebrates: Identification, mode of action and functional significance

Frontiers in Endocrinology, 2010
Steroids synthesized de novo by the central and peripheral nervous systems are called neurosteroids. The formation of neurosteroids from cholesterol in the brain was originally demonstrated in mammals by Baulieu and colleagues.
Kazuyoshi eTsutsui, Shogo eHaraguchi, Masahiro eMatsunaga, Kazuhiko eInoue, Kazuhiko eInoue, Hubert eVaudry   +5 more
doaj   +1 more source

The Sooner, the Better: Neuroprotective Strategies in Fetuses With Congenital Heart Disease

Prenatal Diagnosis, Volume 46, Issue 3, Page 368-381, March 2026.
ABSTRACT Congenital heart disease (CHD) is the most frequent congenital malformation at birth and is associated with neurodevelopmental impairments. Alterations in cardiovascular physiology can lead to reduced cerebral blood perfusion and oxygenation, which negatively affects brain growth and maturation.
Maaike Nijman, Mirthe E. M. van der Meijden, Johannes M. P. J. Breur, Raymond Stegeman, Nicolaas J. G. Jansen, Mireille N. Bekker, Manon J. N. L. Benders, Nathalie H. P. Claessens   +7 more
wiley   +1 more source