Results 111 to 120 of about 16,231 (234)

Prechemotherapy Levels of Plasma Dehydroepiandrosterone and Its Sulfated Form as Predictors of Cancer-Related Cognitive Impairment in Patients with Breast Cancer Receiving Chemotherapy. [PDF]

, 2019
Study objectiveDehydroepiandrosterone (DHEA) and its sulfated form (DHEAS)-jointly referred to as DHEA(S)-are neurosteroids known to regulate brain development and function that have been found to be positively correlated with cognitive function.
Bansal, Sumit, Chan, Alexandre, Lau, Aik Jiang, Shariq Mujtaba, Juliana, Shwe, Maung, Toh, Yi Long, Yeo, Angie   +6 more
core   +2 more sources

Social isolation as a promising animal model of PTSD comorbid suicide: neurosteroids and cannabinoids as possible treatment options.

Progress in Neuro-psychopharmacology and Biological Psychiatry, 2019
Post-traumatic stress disorder (PTSD) is a psychiatric condition characterized by drastic alterations in mood, emotions, social abilities and cognition. Notably, one aspect of PTSD, particularly in veterans, is its comorbidity with suicide.
A. Locci, G. Pinna
semanticscholar   +1 more source

Analysis of Neurosteroids

YAKUGAKU ZASSHI, 1997
The term neurosteroids applies to those steroids that are both synthesized in the nervous system, either de novo from cholesterol or from steroid hormone precursors, and that accumulate in the nervous system to levels that are at least in part independent of steroidogenic gland secretion rates.
openaire   +3 more sources

Pregnanolone-Based Prodrugs as a Strategy for Neuroprotective Drug-Like Compounds: Pregnanolone Pyroglutamate and Its Age‑dependent Anticonvulsant Effects in the 6-hz Seizure Model in Immature Rats

Drug Design, Development and Therapy
Pavel Mareš,1 Hana Chodounská,2 Ewa Szczurowska,2 Hana Kubová,1 Eva Kudova2 1Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic; 2Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech ...
Mareš P, Chodounská H, Szczurowska E, Kubová H, Kudova E   +4 more
doaj  

Neurosteroid Biosynthesis and Action in the Purkinje Cell

Journal of Experimental Neuroscience, 2009
It is now clearly established that steroids can be synthesized de novo by the vertebrate brain. Such steroids are called neurosteroids. To understand neurosteroid action in the brain, data on the regio- and temporal-specific synthesis of neurosteroids ...
Kazuyoshi Tsutsui
doaj   +1 more source

Neurosteroid Metabolites of Gonadal Steroid Hormones in Neuroprotection: Implications for Sex Differences in Neurodegenerative Disease

Frontiers in Molecular Neuroscience, 2018
Gonadal steroid hormones are neurotrophic and neuroprotective. These effects are modulated by local metabolism of the hormones within the brain. Such control is necessary to maintain normal function, as several signaling pathways that are activated by ...
Ari Loren Mendell, Neil James MacLusky
doaj   +1 more source

New Biosynthesis and Biological Actions of Avian Neurosteroids

Journal of Experimental Neuroscience, 2013
De novo neurosteroidogenesis from cholesterol occurs in the brain of various avian species. However, the biosynthetic pathways leading to the formation of neurosteroids are still not completely elucidated.
Kazuyoshi Tsutsui, Shogo Haraguchi, Kazuhiko Inoue, Hitomi Miyabara, Takayoshi Ubuka, Megumi Hatori, Tsuyoshi Hirota, Yoshitaka Fukada   +7 more
doaj   +1 more source

Diverse voltage-sensitive dyes modulate GABAA receptor function [PDF]

, 2010
Voltage-sensitive dyes (VSDs) are important tools for assessing network and single-cell excitability, but an untested premise in most cases is that the dyes do not interfere with the parameters (membrane potential, excitability) that they are designed to
Chisari, Mariangela, Eisenman, Lawrence N, Mennerick, Steven, Shu, Hong-Jin, Taylor, Amanda, Vasek, Michael, Zorumski, Charles F   +6 more
core   +2 more sources

Zinc reduces antiseizure activity of neurosteroids by selective blockade of extrasynaptic GABA‐A receptor‐mediated tonic inhibition in the hippocampus

Neuropharmacology, 2019
Zinc is an abundant trace metal in the hippocampus nerve terminals. Previous studies demonstrate the ability of zinc to selectively block neurosteroid‐sensitive, extrasynaptic GABA‐A receptors in the hippocampus (Carver et al, 2016).
Shu-Hui Chuang, D. Reddy
semanticscholar   +1 more source

Assessment of neuroactive steroids in cerebrospinal fluid comparing acute relapse and stable disease in relapsing-remitting multiple sclerosis [PDF]

, 2016
Previous studies have reported an involvement of neuroactive steroids as neuroprotective and anti-inflammatory agents in neurological disorders such as multiple sclerosis (MS); an analysis of their profile during a specific clinical phase of MS is ...
Bues, B., CALIGNANO, ANTONIO, Carotenuto, A., Cerillo, I., Mangone, G., OREFICE, GIUSEPPE, OREFICE, NICOLA SALVATORE, Rehm, R., SACCA', FRANCESCO   +8 more
core   +1 more source