Results 11 to 20 of about 16,231 (234)
Neurosteroids and Seizure Activity [PDF]
Frontiers in Endocrinology, 2020 Still circa 25% to 30% of patients with epilepsy cannot be efficiently controlled with available antiepileptic drugs so newer pharmacological treatment options have been continuously searched for.
Barbara Miziak +2 more
doaj +4 more sources
Neurosteroids Progesterone and Dehydroepiandrosterone: Molecular Mechanisms of Action in Neuroprotection and Neuroinflammation [PDF]
PharmaceuticalsNeurosteroids pregnenolone, progesterone, allopregnanolone, and dehydroepiandrosterone have been actively studied in the last years as candidates for the treatment of neurodegenerative diseases and postinjury rehabilitation.
Tatiana A. Fedotcheva +1 more
doaj +2 more sources
Neurosteroids in Schizophrenia: Pathogenic and Therapeutic Implications
Frontiers in Psychiatry, 2018 Neurosteroids are a group of important endogenous molecules affecting many neural functions in the brain. Increasing evidence suggests a possible role of these neurosteroids in the pathology and symptomatology of schizophrenia (SZ) and other mental ...
HuaLin Cai +8 more
doaj +2 more sources
Neurosteroids and Focal Epileptic Disorders [PDF]
International Journal of Molecular Sciences, 2020 Neurosteroids are a family of compounds that are synthesized in principal excitatory neurons and glial cells, and derive from the transformation of cholesterol into pregnenolone.
M. Lévesque, G. Biagini, M. Avoli
semanticscholar +3 more sources
Probing GABAA receptors with inhibitory neurosteroids [PDF]
Neuropharmacology, 2018 γ-aminobutyric acid type A receptors (GABAARs) are important components of the central nervous system and they are functionally tasked with controlling neuronal excitability.
Bright, DP +3 more
core +2 more sources
Chronic Stress, 2018 Allopregnanolone and pregnanolone—neurosteroids synthesized from progesterone in the brain, adrenal gland, ovary and testis—have been implicated in a range of neuropsychiatric conditions including seizure disorders, post-traumatic stress disorder, major ...
Jennifer J. Liang, Ann M. Rasmusson
doaj +2 more sources
Neuroprotective actions of neurosteroids [PDF]
Frontiers in Endocrinology, 2011 Neurosteroids were initially defined as steroid hormones locally synthesized within the nervous tissue. Subsequently, they were described as steroid hormone derivatives that devoid hormonal action but still affect neuronal excitability through modulation
Kinga eBorowicz +4 more
doaj +3 more sources
Researh Topic : Neurosteroids [PDF]
Frontiers in Endocrinology, 2012 Thirty years ago, the group of Baulieu and colleagues discovered that certain steroid hormones were present in higher amounts in the brain than in the plasma, and also found that suppression of circulating steroids by adrenalectomy and castration does not affect the concentration of pregnenolone, dehydroepiandrosterone, and their sulfate esters in the ...
Hubert eVaudry, Kazuyoshi eTsutsui
doaj +3 more sources
Endogenous oestrogens as neuroprotective modulators in the human retina: Evidence from transcriptomic profiling and aromatase inhibition. [PDF]
J NeuroendocrinolSingle‐cell transcriptomics reveals that the human retina expresses a broad repertoire of steroid hormone biosynthesis and estrogen signalling genes. Functional validation in retinal explants shows that local estrogen synthesis is neuroprotective, preventing photoreceptor death and limiting microglial activation. Abstract Steroid hormones, particularly
Canto A +6 more
europepmc +2 more sources
The endogenic neurosteroid system and its role in the pathogenesis and therapy of mental disorders
Research Results in Pharmacology, 2023 Introduction: Although neurosteroids have been relatively recently discovered, their significant role in the neurochemical processes and pathogenesis of a number of psychiatric and neurological disorders is now quite clear.
Sakeena P. Bairamova +7 more
doaj +1 more source