Results 21 to 30 of about 16,231 (234)
Gender and Neurosteroids: Implications for Brain Function, Neuroplasticity and Rehabilitation
International Journal of Molecular Sciences, 2023 Neurosteroids are synthesized de novo in the nervous system; they mainly moderate neuronal excitability, and reach target cells via the extracellular pathway.
L. Raciti +4 more
semanticscholar +1 more source
Journal of Pharmacology and Experimental Therapeutics, 2023 This article describes recent advances in the use of neurosteroids as novel anticonvulsants for refractory status epilepticus (RSE) and as medical countermeasures (MCs) for organophosphates and chemical nerve agents (OPNAs).
D. Reddy
semanticscholar +1 more source
Neurosteroids: mechanistic considerations and clinical prospects
Neuropsychopharmacology, 2023 Like other classes of treatments described in this issue’s section, neuroactive steroids have been studied for decades but have risen as a new class of rapid-acting, durable antidepressants with a distinct mechanism of action from previous antidepressant
J. Maguire, S. Mennerick
semanticscholar +1 more source
Pharmacology and Therapeutics, 2022 Alcohol Use Disorder (AUD) is a multifaceted relapsing disorder that is commonly comorbid with psychiatric disorders, including anxiety. Alcohol exposure produces a plethora of effects on neurobiology.
Eleonora Gatta +4 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2021 Even though major depressive disorder (MDD) and post-traumatic stress disorder (PTSD) are among the most prevalent and incapacitating mental illnesses in the world, their diagnosis still relies solely on the characterization of subjective symptoms (many ...
F. B. Almeida, H. Barros, G. Pinna
semanticscholar +1 more source
Reduced neurosteroid potentiation of GABAA receptors in epilepsy and depolarized hippocampal neurons [PDF]
, 2020 OBJECTIVE: Neurosteroids regulate neuronal excitability by potentiating γ-aminobutyric acid type-A receptors (GABARs). In animal models of temporal lobe epilepsy, the neurosteroid sensitivity of GABARs is diminished and GABAR subunit composition is ...
Jansen, Laura A +3 more
core +2 more sources
Neurosteroids and early-life programming: An updated perspective
Current Opinion in Endocrine and Metabolic Research, 2022 Early-life stress can lead to detrimental offspring outcomes, including an increased risk for mood disorders and hypothalamic–pituitary–adrenal axis dysregulation. Neurosteroids bind to ligand-gated neurotransmitter receptors, rapidly modulating neuronal
Y. Sze, P. Brunton
semanticscholar +1 more source
iScience, 2020 Summary: Neuroactive steroids, termed neurosteroids, are synthesized locally in the brain and influence biological functions including cognition and behavior.
Kanako Maehata +8 more
doaj +1 more source
Neurosteroids: A novel promise for the treatment of stroke and post‐stroke complications
Journal of Neurochemistry, 2021 Stroke is the primary reason for death and disability worldwide, with few treatment strategies to date. Neurosteroids, which are natural molecules in the brain, have aroused great interest in the field of stroke.
Jiawei Xu +10 more
semanticscholar +1 more source
Deletion of the gabra2 gene results in hypersensitivity to the acute effects of ethanol but does not alter ethanol self administration [PDF]
, 2012 Human genetic studies have suggested that polymorphisms of the GABRA2 gene encoding the GABA(A) α2-subunit are associated with ethanol dependence. Variations in this gene also convey sensitivity to the subjective effects of ethanol, indicating a role in ...
A Agrawal +46 more
core +10 more sources