Results 31 to 40 of about 16,231 (234)
Frontiers in Endocrinology, 2011 This review highlights the role of major endogenous neurosteroids in seizure disorders and the promise of neurosteroid replacement therapy in epilepsy. Neurosteroids are endogenous modulators of seizure susceptibility.
D. Samba eReddy
doaj +1 more source
Neuroactive steroids in depression and anxiety disorders: Clinical studies [PDF]
, 2006 Certain neuroactive steroids modulate ligand-gated ion channels via non-genomic mechanisms. Especially 3 alpha-reduced pregnane steroids are potent positive allosteric modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor.
Akwa Y +79 more
core +1 more source
Neurosteroids and their role in sex-specific epilepsies
Neurobiology of Disease, 2014 Neurosteroids are involved in sex-specific epilepsies. Allopregnanolone and related endogenous neurosteroids in the brain control excessive neuronal excitability and seizure susceptibility.
Doodipala Samba Reddy
doaj +1 more source
GABAergic neuroactive steroids: a new frontier in bipolar disorders?
Behavioral and Brain Functions, 2012 Neurosteroids are synthesized in the brain and modulate brain excitability. There is increasing evidence of their sedative, anesthetic and antiseizure properties, as well as their influence on mood.
Carta Mauro Giovanni +2 more
doaj +1 more source
The postfinasteride syndrome; an overview [PDF]
, 2016 As a 5-α reductase inhibitor, Finasteride has proven effective in ameliorating two conditions documented to be androgen dependent, namely male androgenic alopecia and benign prostatic hyperplasia. Therapeutic results are maintained as long as the drug is
Banu, Petrisor +9 more
core +7 more sources
Synthetic epoxy-pregnan steroids: effects on anxiety behavior in rats [PDF]
, 2016 Neurosteroids like 3α-OH-5α-pregnan-20-one (allopregnanolone) and 3α-OH-5β-pregnan-20-one (pregnanolone) modulate the γ-aminobutyric acid-A (GABAA) receptor function and produce several effects that can be considered for therapeutical pruposes like ...
Coirini, Hector +2 more
core +1 more source
Ethanol enhances neurosteroidogenesis in hippocampal pyramidal neurons by paradoxical NMDA receptor activation [PDF]
, 2011 Using an antibody against 5α-reduced neurosteroids, predominantly allopregnanolone, we found that immunostaining in the CA1 region of rat hippocampal slices was confined to pyramidal neurons.
Izumi, Yukitoshi +2 more
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Essays in Biochemistry, 2020 Neurosteroids are steroid hormones synthesised de novo in the brain and peripheral nervous tissues. In contrast to adrenal steroid hormones that act on intracellular nuclear receptors, neurosteroids directly modulate plasma membrane ion channels and ...
Emyr Lloyd-Evans, Helen Waller-Evans
semanticscholar +1 more source
Neurosteroids and neurological disorders. [PDF]
Korean J Physiol PharmacolNeurosteroids play an important role as endogenous neuromodulators that are locally produced in the central nervous system and rapidly change the excitability of neurons and the activation of microglial cells and astrocytes. Here we review the mechanisms of synthesis, metabolism, and actions of neurosteroids in the central nervous system. Neurosteroids
Park GW, Kim H, Won SH, Kim NH, Choi SR.
europepmc +3 more sources
Multiple functional neurosteroid binding sites on GABAA receptors [PDF]
, 2019 Neurosteroids are endogenous modulators of neuronal excitability and nervous system development and are being developed as anesthetic agents and treatments for psychiatric diseases.
Akk, Gustav +12 more
core +3 more sources