Results 41 to 50 of about 16,231 (234)

Realising the therapeutic potential of neuroactive steroid modulators of the GABA_A receptor [PDF]

, 2020
In the 1980s particular endogenous metabolites of progesterone and of deoxycorticosterone were revealed to be potent, efficacious, positive allosteric modulators (PAMs) of the GABAA receptor (GABAAR).
Belelli, Delia, Gee, Kelvin W., Hogenkamp, Derk, Lambert, Jeremy J.   +3 more
core   +1 more source

Neurosteroids as regulators of neuroinflammation.

Frontiers in neuroendocrinology (Print), 2019
Neuroinflammation is a physiological protective response in the context of infection and injury. However, neuroinflammation, especially if chronic, may also drive neurodegeneration. Neurodegenerative diseases, such as multiple sclerosis (MS), Alzheimer's
Canelif Yilmaz, K. Karali, Georgia Fodelianaki, A. Gravanis, T. Chavakis, I. Charalampopoulos, V. Alexaki   +6 more
semanticscholar   +1 more source

Temporal changes in the expression of the translocator protein TSPO and the steroidogenic enzyme 5a-reductase in the dorsal spinal cord of animals with neuropathic pain: effects of progesterone administration [PDF]

, 2016
Neuropathic pain is a frequent complication of spinal cord injury (SCI), still refractory to conventional treatment. The presence and biological activity of steroidogenic regulatory proteins and enzymes in the spinal cord suggests that neurosteroids ...
Adler, Natalia Sol, Coronel, Maria Florencia, de Nicola, Alejandro Federico, Gonzalez, Susana Laura, Labombarda, Maria Florencia, Raggio, María Celeste, Sánchez Granel, María Luz   +6 more
core   +2 more sources

Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist induced conformational states of the channel vestibule [PDF]

, 2015
N-methyl-D-aspartate receptors (NMDARs) mediate synaptic plasticity, and their dysfunction is implicated in multiple brain disorders. NMDARs can be allosterically modulated by numerous compounds, including endogenous neurosteroid pregnanolone sulfate ...
A Malayev, A Sali, A Villarroel, AI Sobolevskii, AI Sobolevsky, AI Sobolevsky, AI Sobolevsky, BO Dubrovsky, C Beck, CE Weaver, CE Weaver Jr., CH Lee, CL Kussius, CT Smothers, CT Smothers, E Karakas, E Stastna, EE Baulieu, G Abdrachmanova, GQ Chen, H Havlikova, HR Chang, I Cerny, J Borovska, J Dai, J Zuo, JA Kemp, K Kashiwagi, K Vales, L Nowak, L Rambousek, L Vyklicky Jr., LM Arnostova, LP Wollmuth, M Benveniste, M Hollmann, M Horak, M Korinek, M Park-Chung, M Park-Chung, M Park-Chung, M Petrovic, M Sheng, M Xu, MA Larkin, MA Lomize, MA Lynch, MF Sanner, ML Mayer, MM Zarei, N Kashiwabuchi, NJ Sucher, PA Lapchak, R Kancheva, R Kazi, R Sprengel, RH Evans, S Schreier, SE Murthy, SF Traynelis, SH Mellon, SI Mota   +61 more
core   +1 more source

Site-specific effects of neurosteroids on GABAA receptor activation and desensitization

bioRxiv, 2020
This study examines how site-specific binding to the three identified neurosteroid binding sites in the α1β3 GABAA receptor (GABAAR) contributes to neurosteroid allosteric modulation. We found that the potentiating neurosteroid, allopregnanolone, but not
Yusuke Sugasawa, Wayland W. L. Cheng, John R Bracamontes, Ziwei Chen, Lei Wang, Allison L Germann, Spencer R Pierce, Thomas C. Senneff, K. Krishnan, David E Reichert, D. Covey, G. Akk, A. Evers   +12 more
semanticscholar   +1 more source

Neurosteroids and epilepsy [PDF]

Current Opinion in Neurology, 2010
Neurosteroids are a family of compounds synthesized directly in the brain by transforming cholesterol into pregnenolone, which is then converted to compounds such as allopregnanolone and allotetrahydrodeoxycorticosterone. In view of their ability to modulate neurotransmission, neurosteroids may influence the clinical course of epileptic disorders.
Giuseppe Biagini, Gabriella Panuccio, AVOLI, Massimo   +2 more
openaire   +4 more sources

Role of Hormones and Neurosteroids in Epileptogenesis

Frontiers in Cellular Neuroscience, 2013
This article describes the emerging evidence of hormonal influence on epileptogenesis, which is a process whereby a brain becomes progressively epileptic due to an initial precipitating event of diverse origin such as brain injury, stroke, infection, or ...
D Samba eReddy
doaj   +1 more source

Midazolam inhibits hippocampal long-term potentiation and learning through dual central and peripheral benzodiazepine receptor activation and neurosteroidogenesis [PDF]

, 2010
Benzodiazepines (BDZs) enhance GABA(A) receptor inhibition by direct actions on central BDZ receptors (CBRs). Although some BDZs also bind mitochondrial receptors [translocator protein (18 kDa) (TSPO)] and promote the synthesis of GABA-enhancing ...
Izumi, Yukitoshi, O\u27Dell, Kazuko A, Tokuda, Kazuhiro, Zorumski, Charles F   +3 more
core   +2 more sources

Treatment of Postpartum Depression with Neurosteroids

Neurologijos seminarai
Neurosteroids, such as allopregnanolone, are primarily synthesized substances in the central nervous system which influence processes occurring in the brain.
Reda Stankevičiūtė, Robertas Strumila
doaj   +3 more sources

Neurosteroids and GABAA receptor interactions: a focus on stress

Frontiers in Neuroscience, 2011
Since the pioneering discovery of the rapid CNS depressant actions of steroids by the father of stress, Hans Seyle 70 years ago, brain-derived neurosteroids have emerged as powerful endogenous modulators of neuronal excitability.
Benjamin George Gunn, Adam Richard Brown, Jeremy John Lambert, Delia eBelelli   +3 more
doaj   +1 more source