Results 51 to 60 of about 16,231 (234)

Pineal Neurosteroids: Biosynthesis and Physiological Functions

Frontiers in Endocrinology, 2020
Similar to the adrenal glands, gonads, and placenta, vertebrate brains also produce various steroids, which are known as “neurosteroids.” Neurosteroids are mainly synthesized in the hippocampus, hypothalamus, and cerebellum; however, it has recently been
Shogo Haraguchi, Kazuyoshi Tsutsui
doaj   +1 more source

Neurosteroid biosynthesis and function in the brain of domestic birds

Frontiers in Endocrinology, 2011
It is now established that the brain and other nervous systems have the capability of forming steroids de novo, the so-called neurosteroids. The pioneering discovery of Baulieu and his colleagues, using rodents, has opened the door to a new research ...
Kazuyoshi eTsutsui
doaj   +1 more source

Glia–neuron interactions: Neurosteroids [PDF]

Epilepsia, 2010
SummaryGlial cells have both beneficial and detrimental effects on recovery from brain damage and play a role in epileptogenesis. Herein, we summarize evidence indicating that the ability of astrocytes to produce neurosteroids that reinforce γ‐aminobutyric acid receptor A (GABAA) functions impinge on epileptogenesis, as shown in temporal lobe epilepsy ...
BIAGINI, Giuseppe, M. Avoli
openaire   +1 more source

The brain of teleost fish, a source and a target of sexual steroids

Frontiers in Neuroscience, 2011
Neurosteroids are defined as steroids de novo synthesized in the central nervous system. While the production of neurosteroids is well documented in mammals or amphibians, there is little information in teleosts, the largest group of fish.
Nicolas eDiotel, Jean-Luc eDo-Rego, Isabelle eAnglade, Colette eVaillant, Elisabeth ePellegrini, Hubert eVaudry, Olivier eKah   +6 more
doaj   +1 more source

Sexual steroids and functions of the brain [PDF]

Гинекология, 2017
Neurosteroids are endogenous modulators of nervous excitability. There is increasing evidence of sedative, anxiolytic, analgesic and anticonvulsant properties of neurosteroids.
N N Stenyaeva, D F Chritinin, V Yu Grigoriev, A A Kusemin   +3 more
doaj  

Neurosteroids and GABAergic signaling in health and disease

Biomolecular Concepts, 2013
Endogenous neurosteroids such as allopregnanolone, allotetrahydrodeoxycorticosterone, and androstanediol are synthesized either de novo in the brain from cholesterol or are generated from the local metabolism of peripherally derived progesterone or ...
MacKenzie Georgina, Maguire Jamie
doaj   +1 more source

Synthetic neurosteroids on brain protection

Neural Regeneration Research, 2015
Neurosteroids, like allopregnanolone and pregnanolone, are endogenous regulators of neuronal excitability. Inside the brain, they are highly selective and potent modulators of GABA A receptor activity.
Mariana Rey, Héctor Coirini
doaj   +1 more source

Endogenous neurosteroids influence synaptic GABA_A receptors during post-natal development [PDF]

, 2017
GABA plays a key role in both embryonic and neonatal brain development. For example, during early neonatal nervous system maturation, synaptic transmission, mediated by GABA A receptors (GABA ARs), undergoes a temporally specific form of synaptic ...
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TSPO: kaleidoscopic 18-kDa amid biochemical pharmacology, control and targeting of mitochondria [PDF]

, 2016
The 18-kDa translocator protein (TSPO) localizes in the outer mitochondrial membrane (OMM) of cells and is readily up-regulated under various pathological conditions such as cancer, inflammation, mechanical lesions and neurological diseases. Able to bind
Aghazadeh, Aghazadeh, Alho, Amitani, Anholt, Anholt, Anholt, Anholt, Antkiewicz-Michaluk, Arbo, Banati, Banati, Bar-Ami, Barron, Basile, Batarseh, Batarseh, Batarseh, Batarseh, Batra, Beinlich, Benavides, Bernassau, Besman, Bird, Bitran, Bose, Boujrad, Boujrad, Braestrup, Bribes, Bribes, Brunette, Cagnin, Campanella, Campioli, Casellas, Chauveau, Chen, Chen, Cho, Clark, Colasanti, Corcia, Costa, Costa, Costa, Cuhlmann, Daugherty, De Souza, Decaudin, Decker, Delavoie, Delerive, Doperalski, Enders, Epstein, Fafalios, Fan, Fan, Fan, Fur, Fur, Galiegue, Gastaldello, Gatliff, Gatliff, Gavish, Gavish, Gazouli, Gehlert, Gerhard, Gervois, Giatti, Giatzakis, Giatzakis, Golani, Gonzalez-Polo, Guillon, Gulyas, Guo, Guo, Gut, Hardwick, Hardwick, Hauet, Hauet, Jamin, Jaremko, Jaremko, Jemma Gatliff, Joo, Joseph-Liauzun, Karlstetter, Kita, Kondo, Konigsrainer, Korkhov, Kreisl, Kruczek, Kumar, Lacapere, Lacapere, Lavisse, Li, Li, Li, Li, Li, Li, Libby, Liu, Liu, Maia, Maury, Mazurika, McEnery, Miao, Michelangelo Campanella, Midzak, Midzak, Miettinen, Miller, Mills, Mizrahi, Morohaku, Murail, Nagler, Obame, Oberto, Olson, Ostuni, Ouchi, Owen, Owen, Owen, Papadopoulos, Papadopoulos, Papadopoulos, Papadopoulos, Papadopoulos, Papadopoulos, Papadopoulos, Paradis, Pastorino, Pelechano, Petrescu, Poynter, Raghavan, Rey, Romeo, Rone, Rosenberg, Rosenberg, Rosenberg, Rupprecht, Rupprecht, Scarf, Schaller, Selvaraj, Shoukrun, Sileikyte, Soustiel, Sutter, Tang, Taylor, Teboul, Thompson, Trincavelli, Tu, Tu, Tu, Vanhee, Varrone, Vega, Verma, Wang, Wang, Wei, Whalin, Xiao, Yang, Yang, Yasuno, Yeliseev, Yoder, Zhang, Zhang, Zhao, Zhou   +189 more
core   +1 more source

Defining the end point of status epilepticus: A scoping review and framework for standardization

Epilepsia, EarlyView.
Abstract Status epilepticus (SE) is a life‐threatening neurological emergency with consensus‐driven definitions for onset but no standardized criteria for its end point. This gap creates uncertainty in research and clinical practice. We conducted a scoping review to evaluate how end points have been defined in SE research and to identify key areas of ...
Fawad A. Khan, Margaret T. Gopaul, Samuel L. Carter, Anil Chimakurthy, Summer Skelton, Lawrence J. Hirsch, Eugen Trinka   +6 more
wiley   +1 more source