Results 71 to 80 of about 16,231 (234)

The Effects of Neurosteroids, such as Pregnenolone Sulfate and its receptor, TrpM3 in the Retina. [PDF]

, 2019
Pregnenolone sulfate (PregS) is the precursor to all steroid hormones and is produced in neurons in an activity dependent manner. Studies have shown that PregS production is upregulated during certain critical periods of development, such as in the first
Webster, Corey Michael
core  

Hormonal regulation of female reproduction [PDF]

, 2012
Reproduction is an event that requires the coordination of peripheral organs with the nervous system to ensure that the internal and external environments are optimal for successful procreation of the species.
Bentley, G. E., Cabrera Kreiker, Ricardo Jorge, Christensen, A., Micevych, P., Ortega, Hugo Hector, Perfito, N., Wu, T. J.   +6 more
core   +1 more source

Psychosocial and menstrual correlates of premenstrual disorders: A community‐based study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To assess the background, psychosocial, and menstrual factors associated with premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) in a community‐based cohort. Methods A prospective cohort study was conducted using data from users of a menstrual tracking application.
Shiori Itoi, Makiko Sampei, Takayuki Tatsumi, Yutaka Osuga, Kaori Koga, Satoshi Narumi, Naho Morisaki   +6 more
wiley   +1 more source

Zuranolone – synthetic neurosteroid in treatment of mental disorders: narrative review

Frontiers in Psychiatry, 2023
With each passing year, the number of people suffering from mental disorders grows at a disturbing speed. Neuroactive steroids are a new promising group of drugs with the potential for use in many diseases like postpartum depression, postnatal psychosis,
Rafał Marecki, Joanna Kałuska, Agata Kolanek, Dominika Hakało, Napoleon Waszkiewicz   +4 more
doaj   +1 more source

Lack of neurosteroid selectivity at δ vs. γ2-containing GABAA receptors in dentate granule neurons [PDF]

, 2020
GAB
Lu, Xinguo, Mennerick, Steven, Zorumski, Charles F   +2 more
core   +1 more source

Extrasynaptic γ‐aminobutyric acid type A receptor–mediated sex differences in the antiseizure activity of neurosteroids in status epilepticus and complex partial seizures

Epilepsia, 2019
Sex differences are evident in the antiseizure activity of neurosteroids; however, the potential mechanisms remain unclear. In this study, we sought to determine whether differences in target extrasynaptic δ‐subunit γ‐aminobutyric acid type A (GABA‐A ...
D. Reddy, Chase M. Carver, B. Clossen, Xin Wu   +3 more
semanticscholar   +1 more source

Neurosteroid inhibition of cell death [PDF]

American Journal of Physiology-Renal Physiology, 1997
Diverse γ-aminobutyric acid (GABAA) receptor modulators exhibited novel cytoprotective effects and mechanisms of action in rabbit renal proximal tubules subjected to mitochondrial inhibition (antimycin A) or hypoxia. Cytoprotective potencies (50% effective concentration, EC50) were 0.3 nM allopregnanolone (AP) > 0.4 nM 17α-OH-allopregnanolone (17α ...
S L, Waters, G W, Miller, M D, Aleo, R G, Schnellmann   +3 more
openaire   +2 more sources

FIGO best practice recommendations for the mental health of women at menopausal age

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Mental health during the menopausal transition requires focused attention to ensure supportive experiences for women. This review presents the International Federation of Gynecology and Obstetrics (FIGO) recommendations and summarizes the evidence, addressing 13 key questions framed by members of the FIGO Committee on Women at Menopausal Age ...
Suvarna Khadilkar, Hema Divakar, Chiara Benedetto, Andrea Genazzani, Diana Ramos, Elizabete Argale, Gandhali Deshpande, Martha Hicky, Agnaldo Lopes Da Silva Filho, Enrique Herrera, Milan Balkrishnan   +10 more
wiley   +1 more source

Hexose-6-phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta-hydroxy-neurosteroids.

PLoS ONE, 2007
BackgroundThe role of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) in the regulation of energy metabolism and immune system by locally reactivating glucocorticoids has been extensively studied.
Lyubomir G Nashev, Charlie Chandsawangbhuwana, Zoltan Balazs, Atanas G Atanasov, Bernhard Dick, Felix J Frey, Michael E Baker, Alex Odermatt   +7 more
doaj   +1 more source

Aminoglutethimide prevents excitotoxic and ischemic injuries in cortical neurons [PDF]

, 2006
Aminoglutethimide is a clinically available drug that suppresses steroid biosynthesis by inhibiting enzymes such as cytochrome P450scc and aromatase. Because several members of neurosteroids regulate glutamate receptors, we investigated the effect of ...
Hisashi Shirakawa, Hiroshi Katsuki, Toshiaki Kume, Shuji Kaneko, Akinori Akaike, ALSHOWAIER, BASTIDA, COIRINI, DI SALLE, FOSTER, FUJIMOTO, GUARNERI, HOLMES, IRWIN, KATSUKI, KIMONIDES, KURATA, MARAGAKIS, MATTSON, MELDRUM, MELLON, MILLER, MILLER, NEDERGAARD, NISHIZAWA, PARK-CHUNG, REDDY, ROBEL, SALHANICK, SHIRAKAWA, SHIRAKAWA, UNGER, VEIGA, WEAVER, WEAVER, WEAVER, WU, YAGHOUBI, ZWAIN   +38 more
core   +2 more sources